Apoptosis and carcinogenesis
Soybean lunasin mediates colon carcinogenesis by inducing apoptosis and preventing outgrowth of metastasis
... Figure 1.1 Primary structure of lunasin. It is a 43-amino acid peptide containing a cell adhesion motif, arginine-glycine-aspartic acid, (bold) and a polyaspastic acid tail (italics) responsible for its reported ...
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Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice
... hepatic carcinogenesis in greater detail because human HCC can be closely related to immune response against to cellular damage and infectious ...of apoptosis in cancer cells through targeting OPN and EGFR ...
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ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression
... proliferation, apoptosis, migration, invasion and lamellipodia formation in gastric cancer cells, while ING5 knockdown had the opposite ...decreased apoptosis in SGC-7901 ...and apoptosis in ...
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Ficus septica Burm. f. Leaves Ethanolic Extract Triggered Apoptosis on 7,12-Dimethylbenz[a]anthracene-Induced Rat Mammary Carcinogenesis Qualitatively
... on apoptosis induction and p53 expression against carcinogenesis of 7,12-Dimethylbenz[a]anthracene (DMBA)- induced rat ...both apoptosis induction and p53 expression in DMBA-induced rats that were ...
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Luteolin induces apoptosis in azoxymethane induced colon carcinogenesis through the involvement of Bcl 2, Bax and Caspase 3
... Colorectal cancer (CRC) is a third most common of cancer in worldwide. A predictable mechanism for the development of CRC is an imbalance between cell renewal and cell death. Luteolin (LUT) is a bioflavonoid, has many ...
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Brewers’ rice induces apoptosis in azoxymethane induced colon carcinogenesis in rats via suppression of cell proliferation and the Wnt signaling pathway
... Taken together, treatment of brewers’ rice resulted in the increase of the apoptotic cells, with a maximum effect marked at 40% (w/w) brewers’ rice. A significant increase in the apoptotic cells was also observed in the ...
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Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis
... Premalignant lesions and even some neoplastic tumors are highly dependent of chemical promotion and responsive to treatments that decrease proliferation and increase apopto- sis [45]. Therefore, targeting one or both of ...
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The role of desmosomes in carcinogenesis
... Dovepress Zhou et al expression of DSP could increase cell proliferation associated with elevated phospho-ERK1/2 and phospho-Akt levels. 49 In our studies, we found that DNA methylation contributes to the downregulation ...
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The roles of metallothioneins in carcinogenesis
... called carcinogenesis or oncogen- esis, refers to the formation of a tumor in which normal cells are transformed into cancer ...of apoptosis, such as DNA mutations and epimutations, can contribute to the ...
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The role of TRPV6 in breast carcinogenesis
... 2. Hypothesis and Aim There is almost no information available about the calcium entry mechanism and regulation of the intracellular calcium in breast cancer cells. Studies performed thus far have focused on the role of ...
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Mechanisms of oxysterol-induced carcinogenesis
... inhibit apoptosis [52] and thus contribute to the progression of ...of apoptosis inhibition in carcinogenesis and the dominant anti-apoptotic effects of Mcl-1 in CCA cells, this observation may be ...
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Inhibition of Lung Carcinogenesis by Polymethoxyflavones
... Protein prenylation is required for proper intracellular localization and function of regulatory GTPases including RhoA which is documented to influence many cell cycle regulators. By inhibiting the production of ...
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PTEN deficiency: a role in mammary carcinogenesis
... 34. Rimerman RA, Gellert-Randleman A, Diehl JA: Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation. J Biol Chem 2000, 275:14736-14742. 35. Persad S, Attwell S, Gray V, Delcommenne M, ...
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In vivo cell kinetics in breast carcinogenesis
... of apoptosis were observed in the present ...of apoptosis or a nonspecific uptake of the antibody by apoptotic cells is ...that apoptosis does not always involve entry of cells into the cell ...
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Endometrial Carcinogenesis and Molecular Signaling Pathways
... endometrial carcinogenesis, and the proteins encoded by these genes are the key mediators of several signaling pathways, such as PI3K/AKT/mTOR signaling pathway, WNT/ β -catenin signal transduction cascades ...
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Curcumin: the spicy modulator of breast carcinogenesis
... induced apoptosis in breast cancer cells through up-regulating p21 expression ...independent apoptosis via c-Jun-N-terminal kinase (JNK) activation ...caspase-dependent apoptosis in breast cancer ...
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Esophageal Carcinogenesis
... This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/ Abstract Esophageal cancer is the sixth leading cause of cancer death and remains ...
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Hypermutability in Carcinogenesis
... However, the presence of numerous changes can also be accounted for by efficient selection. What is required to settle the issue is some measure of nonselected mutations in tumors. In order to determine whether the tumor ...
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Carcinogenesis. Carcinogenesis Advance Access published September 26, 2013
... Results Loss of polarity in Ras and ErbB2 transformed MDCK cells requires PKC ι To assess the apparently anomalous requirement for PKCι in normal polarized cells and oncogene- dependent depolarized growth, we established ...
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Carcinogenesis. Carcinogenesis Advance Access published December 28, 2012
... In order to dissect the mechanisms involved in the reduction by fucoidan of tumor growth in 4T1-bearing mice, we further demonstrated that fucoidan suppresses in vitro cells pr[r] ...
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