Apoptosis and disease
Organ specific roles for transcription factor NF κB in reovirus induced apoptosis and disease
... that apoptosis is an impor- tant mechanism of reovirus-induced disease in both the CNS and ...mice, apoptosis and inflammation fol- lowing reovirus infection were ...animals, apoptosis and ...
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Apoptosis in ischemic heart disease
... factor-related apoptosis inducing ligand (TRAIL) represents a very promising marker of prognosis in patients with acute myocardial ...of apoptosis in ischemic heart disease and highlights potentially ...
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Parkinson’s Disease—Apoptosis and Dopamine Oxidation
... Received March 2, 2012; revised April 3, 2012; accepted April 13, 2012 ABSTRACT Tyrosine hydroxylase, monoamine oxidase and aldehyde dehydrogenase all form oxygen radicals as part of their mechanisms of action. These ...
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Oxidative Stress, a-Synuclein, and Apoptosis in Parkinson’s Disease
... Parkinson’s Disease is a neurodegenerative disease that is pathologically characterized by abnormal α -synuclein protein aggregation, dopamine depletion in nigrostriatal neurons, and the subsequent death of ...
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Regulation of apoptosis at the point of cytochrome c in disease models
... c. Apoptosis in chronic neurodegenerative diseases The role of apoptosis remains controversial in various neurodegenerative diseases, as it is difficult to detect apoptotic cells in chronic pathological ...
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Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma
... and Bcl-xL expression in the respect to cirrhosis and CH. In our experience it looks like that the Bcl-2 overexpression characterizes only the late phases of the disease i.e. when HCC develops, while Bcl-xL ...
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The association among leukocyte apoptosis, autoantibodies and disease severity in systemic lupus erythematosus
... undergo apoptosis after immuno-suppressant therapy ...SLE. Disease activity is positively correlated Table 2 Laboratory data of the SLE patients and control ...
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Oncolytic Specificity of Newcastle Disease Virus Is Mediated by Selectivity for Apoptosis-Resistant Cells
... Newcastle disease virus (NDV) is a negative-sense RNA virus that has been shown to possess oncolytic activity. NDV’s selective replication in tumor cells has been previously suggested to be due to the lack of a ...
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Apoptosis and myostatin mRNA are upregulated in the skeletal muscle of patients with chronic kidney disease
... renal disease. It is interesting that both apoptosis and myostatin are upregulated in sarcopenia of aging, suggesting that the findings observed in patients studied herein may represent an acceleration of ...
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The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn’s disease
... s disease with ulcerative colitis-like clinical ...to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain ...
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Regulation of Podocyte apoptosis in Diabetic Kidney Disease : Role of SHIP2, PDK1 and CDK2
... increased apoptosis, and downregulated Akt phosphorylation, BCL-2 protein and upregulated the proapoptotic p38 MAPK pathway and BAX expression confirming their role in podocyte ...from apoptosis by ...
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Analysis of Apoptosis Methods Recently Used in Cancer Research and Cell Death & Disease Publications
... and Disease (2012) 3, e263; ...characterize apoptosis. In order to appropriately identify apoptosis in cellular cultures or in vivo (animal models), with the ultimate aim of discovering novel, ...
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Immunoregulatory mechanisms in Chagas disease: modulation of apoptosis in T cell mediated immune responses
... that apoptosis is associated with low proliferative response, intense T cell activation, high TNF-α production and up-regulation of genes associated with TNF receptors superfamily and caspase family in CARD ...
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The expression of p ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin Beck disease
... Discussion The pathological mechanisms related to KBD are poorly understood. One of the hallmarks of the disease is the apoptosis of chondrocytes. Signaling pathways of JNK and p38 have been associated with ...
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Induction of apoptosis in catecholaminergic PC12 cells by L DOPA Implications for the treatment of Parkinson's disease
... J Clin Invest. 1995;95(6):2458-2464. https://doi.org/10.1172/JCI117946. The hypothesis that L-DOPA therapy in Parkinson's disease may augment neuronal damage and thus accelerate the progression of the ...
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Apoptotic neuron-secreted HN12 inhibits cell apoptosis in Hirschsprung's disease
... in apoptosis can lead to Hirschsprung’s disease (HSCR), which is a genetic disorder of neural crest ...suppress apoptosis of nonapoptotic cells by secreting exosomes that contain high levels of HN12 ...
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Gene Expression Patterns in Myelodyplasia Underline the Role of Apoptosis and Differentiation in Disease Initiation and Progression
... determine disease stage and progression are largely ...different disease stages, using both unselected and CD34 + selected ...opposing apoptosis were dysregulated in MDS cases, most notably MCL1 and ...
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Characterization of apoptosis and autophagy through Bcl-2 and Beclin-1 immunoexpression in gestational trophoblastic disease
... trophoblast apoptosis in placental pathology, including miscarriage, preeclampsia, intrauterine growth restriction, partial and complete hydatidiform mole and ...increased apoptosis reflects the fate of ...
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Ceramides in Alzheimer’s Disease: key mediators of neuronal apoptosis induced by oxidative stress and Aβ accumulation
... 6. Conclusions Ceramides affect various aspects of neuronal physiology determining cell differentiation, growth, survival, senescence, and apoptosis. Postmortem analyses of AD brains reveal alterations of brain ...
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Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis induced acute respiratory distress syndrome
... neutrophil apoptosis and the mean SOFA score, two correlations merit further considera- tion: (a) the correlation between the severity of sepsis and the percentage of neutrophil apoptosis and (b) the ...
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