Apoptosis and gallbladder cancer cells
Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells
... lines. Gallbladder carcinoma is the most common malignancy of the biliary tract, and is a highly aggressive tumor with an extremely poor ...on gallbladder carcinoma are ...on gallbladder ...
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20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway
... of cells that have accumulated potentially oncogenic alterations, is invariably associated with a permanent cell cycle ...of cells in G 0 /G 1 phase was significantly increased in both cell lines following ...
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Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells
... of gallbladder cancer, in particular mutations in components of cell cycle or apoptotic path- ways, and the processes of signal transduction, angio- genesis, invasion, and metastasis ...[21–23]. ...
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Ursolic acid induces cell cycle arrest and apoptosis of gallbladder carcinoma cells
... Results: Our results suggest that UA can significantly inhibit the growth of gallbladder cancer cells. MTT and colony formation assays indicated dose-dependent decreases in cell proliferation. ...
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Evodiamine Induces Extrinsic Apoptosis Through P38 Mapk Pathway and Inhibits Autophagy in Gallbladder Cancer
... The gallbladder cancer is the most common malignant tumor of the biliary tract and the third most common gastrointestinal malignant tumor in the world for public health with extremely poor ...the ...
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Curcumin induces apoptosis in gallbladder carcinoma cell line GBC-SD cells
... Cell apoptosis is an autonomous cell death process, which can be induced by a variety of drugs and physical and chemical ...of apoptosis has been described as a standard and best strategy in anti- ...
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Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling
... ROS are an important mediator of many anti-cancer agents, which are derived from at least two sources: the oxidative protein folding machinery in the endoplasmic reticulum (ER) and mitochondria. Mitochondria ...
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Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting survivin phosphorylation and nuclear export in gallbladder cancer
... induce apoptosis and inhibit cancer cell ...promoting apoptosis and inhibiting cell proliferation ...induce cancer cell apoptosis by activating caspase-9, caspase-3 and poly ADP-ribose ...
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MicroRNA expression and its implications for diagnosis and therapy of gallbladder cancer
... in gallbladder cancer tissues, which are listed in Table ...induce apoptosis in cultured gallbladder cancer NOZ cells, substantiating their roles as tumor suppressors in ...
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Gallbladder cancer: epidemiology and outcome
... Chronic inflammation is inexorably linked to malignant transformation, being a major factor in carcinogenesis. Recurrent or chronic inflammatory insults are detrimental, causing deoxyribonucleic acid (DNA) damage, ...
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Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2
... The cells were washed with cold PBS, fixed in 4% parafor- maldehyde, permeabilized with ...overnight, cells were labeled using FITC-conjugated secondary antibody (Santa Cruz Biotechnology, Santa Cruz, ...
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Postmitochondrial regulation of apoptosis in neurons and cancer cells
... in cells by reduced nicotinamide adenine dinucleotide phosphate (NADPH), which is generated when glucose is metabolized via the pentose phosphate pathway (Kaplowitz, Aw et ...
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Original Article Distribution changes of interstitial cells of Cajal during cholesterol gallstone formation in guinea pigs fed a high cholesterol diet
... with gallbladder disorders. Interstitial cells of Cajal (ICCs) in the gallbladder are important for regulating gallbladder motility and have a close relation- ship with ...of ...
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Manumycin induces apoptosis in prostate cancer cells
... The caspase-family proteins are important for apoptosis. Activation of caspase-9 acts as the initiator of the intrinsic pathway of apoptosis. Therefore, we next investigated the activation of caspase-9. ...
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Risk factors for gallbladder cancer
... Gallbladder cancer was first described nearly 250 years ...This cancer appears to be a multifactorial ...porcelain gallbladder as a result of chronic ...the gallbladder with ...
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Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice
... Previous studies by our group have shown the upregulation of the AKT/mTOR signaling pathway in advanced GBC. Through immunohistochemical assays, we have found that phospho-mTOR and phospho-P70S6K expression are ...
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<p>Columbamine suppresses the proliferation and malignization of colon cancer cells via abolishing Wnt/β-catenin signaling pathway</p>
... Colon cancer is a digestive tract malignancy that occurs in the colon and has already been one of the most common malignancies ...colon cancer in the United States has been declining in recent decades, ...
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Original Article p53 is essential for embelin-induced apoptosis in p53-wildtype prostate cancer cells
... establish cells with an integrated p53 report- er plasmid, the p53luciferase reporter vector (Affymetrix, Santa Clara, CA), which codes for luciferase under the control of a p53 respon- sive element was introduced ...
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Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis
... Pancreatic cancer is a malignant tumor of the digestive tract associated with high ...the cancer is commonly asso- ciated with drug resistance ...pancreatic cancer accounted for 3 and 7%, ...
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<p>Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo</p>
... group, cells were pretreated with 10 μ M LY294002 for 90 min, and then SAL and SFN were added to the medium of the CRC ...The cells were lysed with RIPA buffer containing protease inhibitor cocktail, and ...
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