Apoptosis and Senescence
Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells
... cause apoptosis and senescence of cells. Senescence was determined by β -gal activity and failure to incorporate BrdU or to phosphorylate pRb after fresh medium ...to senescence and then ...
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The effects of astragalus polysaccharide on zebrafish cell apoptosis and senescence
... embryos apoptosis under the concentration of ...early apoptosis of the zebrafish embryos mediated by ...of senescence and this func- tion might by p53-mediated ...
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Anti Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations
... Neuron apoptosis and survival [7]-[10] is determined by Sirt 1 and other anti-aging genes and interventions that prevent down regulation of anti-aging genes may allow appetite regulation with prevention of other ...
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Silence of long noncoding RNA PANDAR switches low-dose curcumin-induced senescence to apoptosis in colorectal cancer cells
... proliferation, apoptosis, or senescence of CRC ...induce senescence in CRC cells without affecting cell ...increased apoptosis and greatly attenuated senescence possibly by stimulating ...
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Effect of kidney ischemia/reperfusion injury on proliferation, apoptosis, and cellular senescence in acute kidney injury in mice
... promotes apoptosis of epithelial cells in the acute phase followed by proliferation of interstitial cells in the chronic episode, and cellular senescence may contribute to development of AKI, however its ...
5
Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence
... to apoptosis induced by anticancer treatment, induction of senescence in tumor cells could be an alternative approach to cancer therapy, and be especially effective in the treatment of cancer cells in which ...
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Effect of senescence on some apoptosis and oxidative stress markers in infertile normozospermic and oligospermic men: A cross-sectional study
... activate apoptosis include toxic metals, environmental toxicants, electromagnetic radiation and chronic medications ...stimulate apoptosis in human germ cells, senescence may predispose living ...
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MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma
... Neddylation is a post-translational protein modification process associated with carcinogenesis and cancer development. MLN4924, a pharmaceutical neddylation inhibitor, induces potent anti-cancer effects in multiple ...
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20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway
... cellular senescence and G 0 /G 1 arrest by 20(S)-Rg3 were accompanied by a large accumulation of p53 and p21 as a result of murine double minute 2 (MDM2) ...in apoptosis via the activation of the ...
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Regulation of human naive and memory T cell populations by apoptosis and replicative senescence
... replicative senescence in antigen specific CD8^ T lymphocytes during and following immune ...escape apoptosis during resolution of AIM, enter the memory pool with a relatively preserved replicative ...
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Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, Senescence, and Apoptosis in HeLa Cervical Carcinoma Cells
... triggered senescence in HeLa cells without activating p53 or inducing p21, whereas E6 repression triggered both senescence and apoptosis without activating the retinoblastoma ...
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Run-on of germline apoptosis promotes gonad senescence in C. elegans
... (non-damage-induced) apoptosis (PA) to provision growing ...germline apoptosis in later life, and report that genetically blocking or increasing PA retards or accelerates degeneration, ...line ...
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Run on of germline apoptosis promotes gonad senescence in C elegans
... Biogerontological studies of C. elegans usually use lifespan as a readout of aging. In this study we have instead focused on age-related pathology. The balance of evidence suggests that gonadal pathology (distal gonad ...
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Small Molecular Weight Modulators of Apoptosis and Senescence
... Since we found that C22 was able to prevent Bax association to the mitochondrial membrane we wanted to determine whether or not C22 was able to prevent the release of cytotoxic factors from the mitochondria into the ...
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Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion
... During normal human ageing, the host immune system becomes poorly functional in terms of cellular responses towards foreign antigens leading to poor naïve T cell turnover and increased expansion of senescent T-cell ...
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Inhibitory effect of phytol on cellular senescence
... dependent manner, as indicated by the reduced expression of the mRNA levels of TNF-α (tumor necrosis factor-alpha), IL6 (interleukin 6), IL8 (interleukin 8), and COX2 (cyclooxygenase 2). Second, the quantitative analysis ...
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Telomeres, stem cells, senescence, and cancer
... ed checkpoints, cultured cells with dysfunctional telomeres continue to proliferate, entering a period of slow growth called “crisis” that is characterized by genomic instability. Clones emerging from crisis invariably ...
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Bmi1, stem cells, and senescence regulation
... and apoptosis (see review, ...in senescence, suggests that stem cells have evolved specific mechanisms to repress senescence and to prolong their capacity to ...of senescence in stem ...
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Strategies targeting cellular senescence
... using senescence-targeted treatments, safety issues might become a major challenge, owing to the physiological role of senes- cent cells and the side effects of the existing ...certain senescence epitopes ...
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Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis
... Figure 3 Radiation induced senescence in KYSE150 and KYSE410 cells and YM155 reduced senescence but enhanced apoptosis. (A) representative images of sa-β-gal (green) staining for the KYSE150 and ...
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