APP, amyloid precursor protein
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
... : amyloid beta-peptide; AD: Alzheimer ’ s disease; APP: amyloid precursor protein; APPsw: Swedish familial Alzheimer ’ s disease mutant isoform of APP: BACE: beta-APP ...
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Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... AICD: Amyloid intracellular domain; APP: Amyloid precursor protein; A β : Amyloid β ; BACE1: β -secretase; CHO: Chinese hamster ovary cell line; CHX: Cycloheximide – inhibitor of ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... vascular amyloid or senile plaques from AD and Down’s syndrome patients, the identifi cation of APP was a logical step forward ...of APP including part of the transmembrane domain, it was apparent ...
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Influence of chlorpyrifos oxon on the development and progression of Alzheimer’s disease in amyloid precursor protein transgenic mice
... of amyloid precursor protein (APP) mice with chlorpyrifos oxon (CPO) results in exaggerated ...Control APP mice and mice treated with CPO were evaluated for inflammatory ...of ...
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Modeling Alzheimer's disease with non-transgenic rat models
... the amyloid precursor protein (APP) and its central role in the familial form of ...human APP gene, were found to be unsatisfactory, and double transgenic mice carrying two human ...
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The genetics of Alzheimer's disease
... the Mendelian inheritance pattern; however, EOAD patients have also been reported without any family history (termed “sporadic EOAD”). Three genes are considered the main risk factors for EOAD: amyloid ...
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Original Article DMT1 inhibitor ebselen inhibits iron-induced amyloidogenic APP processing
... on APP processing, this present study hypothesized that ebselen could modulate amyloid precursor protein (APP) processing and inhibit iron-induced increase of amyloidogenic metabo- ...
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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... pathway, APP can undergo proteolysis by secretase enzymes to release either the Aβ peptide (amyloidogenic pathway) or a shorter, non-toxic peptide known as sAPP (non-amyloidogenic pathway) [20] ...pathway, ...
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Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... : amyloid β peptide; AD: Alzheimer ’ s disease; APH-1: anterior pharynx- defective 1; APP: amyloid β precursor protein; BACE-1: β -site amyloid precursor protein ...
10
The autophagy related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
... a protein with a key role in autophagy, was decreased in affected brain regions of patients with Alzheimer disease (AD) early in the disease ...human amyloid precursor protein (APP), a ...
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Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases
... tau protein deposition over amyloid [109]. The tau protein depos- ition in CTE is interesting since it has been previously demonstrated that tau inhibits kinesin-dependent trans- port of peroxisomes, ...
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Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare clinical entity, characterized by headaches, seizures, rapidly progressive cognitive decline, behavioral changes and magnetic resonance imaging ...
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The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... the amyloid-β protein (Aβ) was isolated from brains with amyloid depositon and it was subsequently identified as the core protein of neuritic plaques ...from amyloid-β precursor ...
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Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivomodel of Alzheimer’s disease
... including amyloid plaques, oxi- dative stress, and ...oid precursor protein (APP) metabolism and resulting Aβ generation seem to be central and early events in the dis- ease ...of APP ...
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Proteomics of protein post translational modifications implicated in neurodegeneration
... more protein spots, where each spot is thought to represent a single, unique protein ...of, protein adducts occurring downstream of lipid peroxidation, where Michael adducts of alpha, beta-alkenal ...
13
Alzheimer’s in a dish – induced pluripotent stem cell based disease modeling
... of APP in early ...of APP in its close proximity enables BACE-1 to readily cleave an abundance of ...in APP dp neurons but not in fAD neurons carrying the PSEN1ΔE9 mutation [89, ...in APP ...
13
Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease
... Central nervous system dysregulated insulin and periph- eral hyperinsulinemia has been shown to be another highly associated phenomenon with AD [31, 64–66]. Insu- lin dysregulation can be characterized by low ratios of ...
9
Early-onset dementias: diagnostic and etiological considerations
... Th ese important pathogenic diff erences between late- onset dementia and EODs have signifi cant future therapeutic implications. Specifi cally, we anticipate that EODs with a hypothetical single (or few) route(s) of ...
22
Decreasing the expression of PICALM reduces endocytosis and the activity of β secretase: Implications for Alzheimer's disease
... on APP endocytosis and ...of APP or βCTF so both PICALM isoforms must be involved in functional endocytosis in the H4 ...the protein and mRNA for isoform 1 but decreased isoform 2 pro- tein without ...
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Use of theragnostic markers to select drugs for phase II/III trials for Alzheimer disease
... the amyloid-targeting drug phenserine also showed changes in CSF Aβ levels in response to treatment ...novel APP-processing pathway [38] that is upregulated in a dose-dependent manner in response to γ- ...
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