APP processing
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease
... proteolytic processing of the amyloid precursor protein (APP) by γ-secretase [20, 22], inhibiting the latter protease is a valuable approach that has been extensively tested in the clinic to prevent and/or ...
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Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
... mediate APP processing/Aβ generation through regulating trafficking of AD associated proteins: SNX17 can interact with APP in the early endosome and downregulation of SNX17 leads to reduced ...
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Original Article DMT1 inhibitor ebselen inhibits iron-induced amyloidogenic APP processing
... on APP processing, this present study hypothesized that ebselen could modulate amyloid precursor protein (APP) processing and inhibit iron-induced increase of amyloidogenic metabo- ...β-site ...
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The effects of different familial Alzheimer’s disease mutations on APP processing in vivo
... small sample size might have had some effect on the outcomes presented here, they are at the very least strongly hypothesis generating. Another limitation is the cross-sectional design of the study, which makes it im- ...
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The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... -site APP cleaving enzyme 1) and γ -secretase are important enzymes in this ...of APP and enzymes is essential for APP processing and A β production but several important questions regarding ...
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Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression
... PS1, AAV-APP and AAV-APP/PS1 mice three months after vector injection. βCTF, the first cleavage product of the amyloidogenic pathway [30] was quantified by ELISA (Fig. 2a). AAV-APP mice produced ...
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TETRAMETHYLPYRAZINE DIMER ALLEVIATES APP PROCESSING AND TAU HYPERPHOSPHORYLATION IN NEURO2A/APPSWE CELLS
... prevent APP processing and tau phosphorylation in the Alzheimer's disease transgenic model ...in APP processing and tau phosphorylation by Western blot ...
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RNAi mediated knock down of Dab and Numb attenuate Aβ levels via γ secretase mediated APP processing
... Small interfering RNA (siRNA) duplex was designed and obtained from Qiagen against human NUMB, the gene encoding Numb (5’- CAGCCTCTTGACCTCGGATAA- 3 ’ ). Dab siRNA duplex for DAB , the gene encoding Dab, was designed and ...
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APP processing in Alzheimer's disease
... regulate APP traffick- ing in a more specific manner, possibly through their direct binding to ...containing APP along with a concomitant increase in complex glycosyla- tion and APP localization at ...
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ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
... regulate APP processing and induce accumulation of intracellular amyloid-β [159,160], (ii) phosphorylate tau protein and trigger aggregation of neurofibrillary tangles [161,162], and (iii) potentiate ...
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EnterVu Recruitment through Data Science and Artificial Intelligence
... Front-end(web-app), processing unit (Google Cloud Compute Engine) and database (Google Cloud Storage, MySQL Google Cloud ...the processing modules concerned with Data Science. The web-app is ...
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A disintegrin metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
... Generation and characterization of ADAM10- overexpressing mouse lines. As a first step to explore the activity of ADAM10 in vivo, we gen- erated transgenic mice expressing — under the control of a neuron-specific ...
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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
... of APP by beta- and gamma-secretases ...of APP processing is unknown, the autophagic and endocytic pathways could be both involved in precursor protein (APP) processing and Abeta ...of ...
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Studies on the use of glycosaminoglycans for the treatment of Alzheimer's Disease
... iii heparin lacking 6-O sulfate were less potent than native heparin. However, deletion of carboxyl groups on MH had no significant effect on APP processing. These data suggest that it might be possible to ...
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Prevention of tick bites: an evaluation of a smartphone app
... mobile app. The app called ‘Tekenbeet’ (Dutch for ‘tick bite’) is a smartphone application aimed at supporting the public in dealing with exposure to ticks and tick ...The app is aimed at the ...
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QuizPower: a mobile app with app inventor and XAMPP service integration
... MIT’s App Inventor development services with a web service hosted by the department ...retrieval app, which could scale well regardless of the number of topics ...our App Inventor codebase and ...
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Assessing the Contribution Antiretroviral Therapy to Neuronal Damage and Death as a Mediator of Cognitive Decline in HIV-Associated Neurocognitive Disorders
... with APP and/or lead to transcriptional and translational upregulation of BACE1 expression in neurons (8, ...of APP was protective against neuronal hyperactivity and excitotoxicity in vitro ...
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Using real-time, anonymous staff feedback to improve staff experience and engagement
... negative. The full roll-out showed similar patterns to the pilot for the themes, with ‘ team working ’ being the most frequent. Figure 1 presents the number of responses each month together with the number of locations ...
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Interaction of prion protein with divalent metals: possible role in neuroprotection and neurodegeneration in prion disease model
... Iron is one of the most important metals required for survival. It is highly regulated in physiological systems to maintain homeostatic balance. Free iron does not exist in physiological systems, and is always found ...
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Extrofitting: Enriching Word Representation and its Vector Space with Semantic Lexicons
... We propose post-processing method for enriching not only word representation but also its vector space using semantic lex- icons, which we call extrofitting. The method consists of 3 steps as follows: (i) ...
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