APP/PS1 mice
Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice
... Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by deposits of amyloid-β and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease; ...
46
Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
... Ellagic acid (EA) is a hydrolyzed form of ellagitannins (ETs), which are abundant in pomegranate, berries, and nuts. Complex dietary EA and ETs are poorly absorbed in humans, but they get further metabolized by gut ...
13
Rosiglitazone improves spatial memory and decreases insoluble A?(1 42) in APP/PS1 mice
... of mice during acquisition, but there was a significant time- related change in mean latency (c) and mean pathlength (d) during the reversal phase ...in APP/PS1 mice than wildtype mice ...
9
Minor ginsenoside F1 improves memory in APP/PS1 mice
... cognitive functions including episodic memory, naviga- tion, and spatial working memory [38]. 6E10 antibody detects all species of Aβ plaque and amyloid precursor protein, while ThS stains the β-sheeted dense core of Aβ ...
8
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits
... month-old APP/PS1 ...−/− APP/PS1 mouse ...−/− mice in experimental autoimmune encephalomyelitis and after intracerebral injection of LPS [19, ...in APP/PS1 mice ...
16
Original Article Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer’s disease
... Transgenic mice overexpressing mutant amyloid precursor protein (APP) alone with or without mutant presenilin 1 (PS1), have shown that brain amyloid plaque development and structure grossly ...
14
Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide
... Based on the above studies, we speculated that ZGM1 can mediate the aggregation of Aβ42 monomers into globulomers, which can be used as seeds in fibril forma- tion. The number of amyloid fibrils can be elevated by ...
16
Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice
... the APP/PS1 group, appearing cognitive impairment which performance as learning and memory ...the APP/ PS1+DU20 group were significantly higher than those in the model group, which promoted ...
10
Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition
... linked to cognitive function and whether stimulating re- generative mechanisms in the brain could restore or pre- vent further deterioration of cognition during the disease process. During the process of synaptic ...
15
Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model
... In conclusion, the results of chronic administration of D- Ala 2 GIP demonstrate that GIP analogues have a range of properties that may be beneficial in treating neurodegen- erative conditions such as AD. It our study, ...
24
Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression
... mutant PS1 overexpression in mouse hippocampus did not in- duce cognitive abnormalities in Morris Water Maze [37] nor in Y-Maze tasks [38], and APP processing profile was similar in WT animals and ...
17
Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer’s-like disease in mice
... Tg mice [25], as well as that 4 months of treatment with citalopram (8 mg/kg/day) per os reduces levels of Aβ and plaque load in the neocortex and hippocampus of 7-month- old APP/PS1 mice ...
12
Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity
... − mice expressed higher mRNA levels of iNOS (264 ± 73% of the LPS-treated Wt control, p < ...−/− mice as compared to the LPS-treated wt ...−/− mice expressed higher mRNA levels of COX-2 (198 ± 48% ...
16
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment
... PS1 mice [F(1,22) = ...rolipram-treated APP/PS1 mice and vehicle-treated APP/PS1 mice in the sixth session (P < ...WT mice spent more time in the target ...
12
URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease
... in APP/PS1 mice, Western blot analysis assessed the relative ex- pression of NOS-2 as a correlate of M1 response and arginase 1 as a correlate of M2 response, respectively ...The ...
14
Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway
... in APP/PS1 mice could be blocked by the PPARγ-specific inhibitor GW9662 (Figure S3); these results agree with the in vitro ...The APP/PS1 transgenic mice were administrated JuA ...
17
Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
... in APP/PS1 mice may have a deleterious effect on A β pathology, and this was associated with heightened levels of corticosterone, in a FAD model that already showed elevated stress hormone levels ...
7
Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice
... Alzheimer’s disease, while characterized by amyloid plaques and neurofibrillary tangles, is associated with a ro- bust neuroinflammatory response. Using the macrophage classification system of M1, M2a, M2b and M2c [6,7] ...
11
Ca2+-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling
... and APP/ PS1 AD ...in APP/PS1 AD mouse model. Elimination of KCa3.1 in KCa3.1 − / − /APP/PS1 mice corrected these abnormal .../APP/PS1 mice, as ...
17
APOE4 mediated amyloid β pathology depends on its neuronal receptor LRP1
... control APP/PS1 mice, thereby exacerbat- ing Aβ pathology ...of APP/PS1 mice expressing apoE3 or apoE4 (Supplemental Figure ...in APP/PS1 mice specifically ...
7