APP/PS1 transgenic mice
Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice
... of transgenic AD mice [27] and are controversially discussed to participate in amyloid clearance (reviewed in [28–30] and ...of transgenic AD mice was already observed by others ([27], ...
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The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice
... The conditioned medium (CM) from BV-2 microglia acti- vated by the Nogo/NgR pathway increased the produc- tion and the aggregation of A β in primary neurons Above results showed that the Nogo/NgR signaling pathway was ...
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Bis(9) (−) Meptazinol, a novel dual binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice
... eight-month-old APP/PS1 transgenic mice for four ...of APP/PS1 transgenic mice in the Morris water maze test, nest-building test and novel object recognition ...in ...
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β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice
... in APP/PS1 transgenic ...the mice were 6 months of ...in APP trans- genic mice have focused on total Aβ changes and have reported both no change in Aβ [10,11] and also modest ...
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Huatuo Zaizao pill ameliorates cognitive impairment of APP/PS1 transgenic mice by improving synaptic plasticity and reducing Aβ deposition
... of PS1 in APP transgenic mice results in a high accumulation of APP-CTFs at the front of the synaptic front, which could lead to impaired synaptic plasticity and long-term memory ...
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Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice
... The Trizol plus RNA purification system (Life Tech- nologies) was used to extract RNA from the frozen right hippocampus according to the manufacturer’s instruc- tions. RNA was quantified using the Biospec nano spec- ...
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Stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice
... 7-month-old APP/PS1 mice received X-ray irradiation to destroy their bone marrow, and the bone marrow of the mice expressing green fluorescent protein (GFP) (UBC-GFP mice with the ...
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Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice
... A sandwich ELISA was performed to confirm that the AAV-8 was an effective vehicle for gene delivery resulting in IL-4 expression. Protein extracts taken from the right frontal cortex showed a marked significant increase ...
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Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice
... The mammalian neurotrophin family, including nerve growth factor, BDNF and neurotrophin-3, activates dif- ferent cell signaling pathways via tyrosine receptor kin- ase. BDNF localizes in the hippocampus, hypothalamus, ...
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Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity
... in APP/PS1 transgenic mice, while sEH immunoreactivity was barely detectable in resting astrocytes with a quiescent ...−/− mice cannot be excluded due to the constant interactions ...
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<p>Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway</p>
... Hippocampal samples of APP/PS1 transgenic mice and C57BL/6 mice were dissected and stored at − 80 ° C before WB analysis. Five samples in each group were processed by extract- ing ...
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Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer’s disease
... (APP/PS1) transgenic mice to study the early pre-pathological effects of increased amyloid- β levels on hippocampal synaptic plasticity and ...in APP/PS1 mice at three ...
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Effects of Curcumin on the Expression of Flotillin 1 in the Brains of APP/PS1 Double Transgenic Mice
... DOI: 10.4236/jbm.2019.75004 17 Journal of Biosciences and Medicines ration of the individual’s personality and failure to communicate or perform routine tasks. Flotillin-1 is a marker protein of lipid raft in nervous ...
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Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway
... In APP/PS1 transgenic mice and Aβ treated microglia, the interaction between HSP90 and PPARγ were analyzed by western ...in APP/PS1 transgenic mice, meanwhile, JuA ...
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The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway
... Thirdly, our observations were proven in APP/PS1 transgenic mice, a common AD animal model. Consistent with our study in vitro, blocking the Nogo/NgR pathway by NEP1-40 significantly induced ...
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Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation
... the mice with APP/PS1 double- transgenic mutation exhibited a sex difference in the neuropathological changes ...AβPP/PS1 transgenic mice, no significant differences of ...
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A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer’s disease
... old APP/PS1 mice reported an increase in amyloid deposition in the retina, specifically in close proximity to retinal micro vessels, which corresponded with the levels detected in the brain ...AD ...
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Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease
... rTgTauEC transgenic mice that demonstrate spread of tau from entorhinal cortex to other brain structures at advanced age with APP/PS1 mice, and examined mice with either NFTs, ...
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Molecular neuroimaging of Alzheimer's disease
... aged transgenic APP/PS1 mice, which have extensive cerebral amyloid ...the mice were sacrificed, their brains were removed and sections were studied according to the fluorescence ...
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Original Article Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer’s disease
... formation. Transgenic mice overexpressing mutant amyloid precursor protein (APP) alone with or without mutant presenilin 1 (PS1), have shown that brain amyloid plaque development and structure ...
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