Aquaporin 3
Immunolocalisation of aquaporin 3 in the gill and the gastrointestinal tract of the European eel Anguilla anguilla (L )
... protein, aquaporin 3 (AQP-3), has been localised within branchial and intestinal tissues from the ‘silver’ life stage of the European eel Anguilla anguilla, using a specific polyclonal antibody ...
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Potential role of aquaporin 3 in gastric intestinal metaplasia
... Gastric intestinal metaplasia (GIM) is a pre-cancerous condition and a pivotal step in the formation of gastric cancer (GC). Aquaporin 3 (AQP3) has been found to be expressed in goblet cells rather than ...
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IN VITRO EXPRESSION STUDIES OF AQUAPORIN-3 (AQP-3) GENE STIMULATION BY PURE ALOE VERA FACE WASH IN KERATINOCYTES .......
... Aquaporin-3 (AQP-3) is the most abundant and important membrane protein that facilitates water transport in and out of keratinocytes and thus possessing a very crucial role of maintaining stable ...
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Aquaporin 3 promotes the stem-like properties of gastric cancer cells via Wnt/GSK-3β/β-catenin pathway
... Cancer stem cells (CSCs) are believed to contribute to the tumor growth in gastric carcinoma (GC), a common lethal malignancy. This study investigated the effect of aquaporin 3 (AQP3) on stem-like ...
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Aquaporin 3 promotes epithelial-mesenchymal transition in gastric cancer
... Aquaporins (AQPs) are a family of small, integral membrane proteins that transport water and, in some cases, water and glycerol. Apart from these physiological functions [12], accumulating evidence further implicates the ...
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Original Article Effects of rhein on intestinal transmission, colonic electromyography and expression of aquaporin-3 by colonic epithelium cells in constipated mice
... Abstract: Constipation is one of the most common gastrointestinal diseases in the world. This study was to inves- tigate the effects of rhein on intestinal transmission and colonic electromyography and expression of ...
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Oxygen-dependent regulation of aquaporin-3 expression
... Abstract: The purpose of this study was to investigate whether aquaporin-3 (AQP3) expression is altered in hypoxia and whether hypoxia-inducible transcription factor (HIF)-1 regulates the hypoxic ...
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Branchial expression of an aquaporin 3 (AQP 3) homologue is downregulated in the European eel Anguilla anguilla following seawater acclimation
... and 3′-RACE (Rapid Amplification of cDNA Ends) DNA fragments were produced from SW- acclimated yellow eel gill mRNA and a Marathon cDNA amplification kit (Clontech, Basingstoke, UK) as described previously (Cutler ...
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Computational Modeling on Aquaporin-3 as Skin Cancer Target: A Virtual Screening and Molecular Dynamic Simulation Study
... To estimate the binding association between the AQP3 protein and the selected 20 poses obtained from dynamic simulation, an MM-GBSA analysis was carried out on the last 10ns of each dynamic simulation trajectory. The ...
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Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells
... A significant increase in MT1-MMP, MMP-2, MMP-9 expression was observed in AQP3 over-expression group compared with control group.* p < 0.05 BLANK control SGC7901 cells NC cells treat[r] ...
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Aquaporin 3 expressed in the basolateral membrane of gill chloride cells in Mozambique tilapia Oreochromis mossambicus adapted to freshwater and seawater
... acid sequences and the predicted six-transmembrane-spanning topology are highly conserved between species and between family members. Among AQP isoforms, AQPs 0, 1, 2, 4 and 5 are considered to be water-selective (Agre ...
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Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease
... investigations: Aquaporin 3 (AQP3), extracellular matrix protein 1 (ECM1), four and a half LIM domain 1 (FHL1), milk fat globule epidermal growth factor 8 (MFGE8, lactadherin), phosphodiesterase ...
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Molecular biomarkers in multiple sclerosis
... Molecular biomarkers enable individual decisions and are an important step on the way to a personalized ther- apy [3, 142]. An ideal biomarker is characterized by high sensitivity and specificity as well as a ...
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Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
... Maintaining normal CSF volume is indispensable to brain health. CSF volume ranges from the greatly reduced spaces in slit ventricle syndrome to the ventriculomegaly of severe hydrocephalus. The dynamics of ventricular ...
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A mutagenic approach to elucidating aquaporin function
... 3.3.2 Both AQP4 isoforms relocalized equally in HEK293 cells Human AQP4 exists in two isoforms: a long M1 form and a shorter M23 form that lacks the initial 22 amino acids of M1 (and there is evidence of further isoforms ...
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Aquaporin expression dynamics in osmoregulatory tissues of Atlantic salmon during smoltification and seawater acclimation
... In contrast to the epithelia of the intestine and kidney tubules, the gill is in direct contact with the surrounding medium and has a potential risk of large transepithelial water fluxes due to the osmotic gradient. From ...
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Neuromyelitis optica pathogenesis and aquaporin 4
... binds aquaporin 4 (AQP4) has been identified in the sera of a significant number of NMO patients, as well as in patients with two related neurologic conditions, bilateral optic neuritis (ON), and longitudinal ...
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Myelinoclastic diffuse sclerosis (Schilder’s disease) is immunologically distinct from multiple sclerosis: results from retrospective analysis of 92 lumbar punctures
... whether the criteria for RRMS were met. As a limitation, it should be stressed that clinical data were sparse in some reports, leaving some doubt regarding the exact clinical course. In one OCB-positive case, the spinal ...
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Low intensity pulsed ultrasound rescues insufficient salivary secretion in autoimmune sialadenitis
... The treatment of SS remains a challenge because most of the randomized controlled trials done to date have failed to demonstrate efficacy of the treatments evaluated. Hydroxychloroquine (HCQ), one of the most frequently ...
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Aquaporin 4: a player in cerebral edema and neuroinflammation
... observed that treatment with small interference RNA (siRNA) targeted against AQP4 (siAQP4) after juvenile TBI showed a decrease in AQP4 associated with less BBB disruption, edema, more NeuN positive cells, and better ...
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