Aquaporin 4
Original Article Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria
... matic aquaporin 4 (AQP4) upregulation, selectively at the level of astrocytic foot processes, in both CM and non-CM disease, but significantly more pronounced in mice with malarial-induced neurological ...
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The critical role of lipopolysaccharide in the upregulation of aquaporin 4 in glial cells treated with Shiga toxin
... Results: Shiga toxin 2 (Stx-2) in combination with lipopolysaccharide (LPS), or LPS alone activates nuclear factor- κ B (NF- κ B) signaling in glial cells. Similarly, Stx-2 in combination with LPS, or LPS alone increases ...
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Aquaporin-4 expression in the cerebrospinal fluid in congenital human hydrocephalus
... Background: Aquaporin-4 (AQP4) is a water channel mainly located in the ventricular ependymal cells (brain-CSF barrier), the sub-ependymal glia, glia limitans and in end-feet of astrocytes in at the blood – ...
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Aquaporin-4 expression in distal myopathy with rimmed vacuoles
... sarcolemmal aquaporin-4 immunoreactivity was reduced in many muscle fibers of the ...of aquaporin-4 staining was markedly increased at rimmed vacuoles or its surrounding areas and in some ...
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Aquaporin 4 is a ubiquitously expressed isoform in the dogfish (Squalus acanthias) shark
... The dogfish ortholog of aquaporin 4 (AQP4) was amplified from cDNA using degenerate PCR followed by cloning and sequencing. The complete coding region was then obtained using 5 and 3 RACE techniques. ...
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Identification and molecular mechanisms of the rapid tonicity induced relocalization of aquaporin 4 channel
... The aquaporin family of integral membrane proteins is com- posed of channels that mediate cellular water ...flow. Aquaporin 4 (AQP4) is highly expressed in the glial cells of the central nerv- ous ...
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MRI Based Methods for Spinal Cord Atrophy Evaluation: A Comparison of Cervical Cord Cross Sectional Area, Cervical Cord Volume, and Full Spinal Cord Volume in Patients with Aquaporin 4 Antibody Seropositive Neuromyelitis Optica Spectrum Disorders
... with aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders and evaluated the discriminatory performance of mean upper cervical cord cross-sectional area compared with cervical cord ...
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The role of anti aquaporin 4 antibody in the conversion of acute brainstem syndrome to neuromyelitis optica
... Acute brainstem syndrome (ABS) is an acute inflammatory demyelinating syndrome of the CNS that may occur in iso- lation or herald multiple sclerosis (MS), neuromyelitis optica (NMO), or recurrences of brainstem syndrome ...
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Different Aquaporin-4 Expression in Glioblastoma Multiforme Patients with and without Seizures
... Aquaporin-4 (AQP-4), the most important water channel in the brain, is expressed by astrocyte end feet abutting microvessels. Altered expression levels of AQP-4 and redistribution of the ...
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An association of Aquaporin 4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicum
... Aquaporin-4 (AQP4), a member of AQPs, was origin- ally cloned in 1994 from lung tissue [19]. Studies show that AQP4 is highly expressed in the CNS and regulates brain volume homeostasis, cerebrospinal fluid ...
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Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays
... Lennon and colleagues discovered a biomarker for NMO; NMO-IgG is an autoantibody initially detected in the serum of 73% of NMO but less than 5% of CMS patients [10], which binds to aquaporin-4 (AQP4) [11], ...
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Original Article Effects of dexamethasone on aquaporin-4 expression in brain tissue of rat with bacterial meningitis
... Aquaporin-4 (AQP4) is one of the most popular water channel protein expressed in brain tissue and play a significant important role in keeping water balance and regulation of water distribu- tion of the ...
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Membrane assembly of aquaporin 4 autoantibodies regulates classical complement activation in neuromyelitis optica
... aquaporin-4 (AQP4) water channel autoantibodies (AQP4-IgG). Although AQP4-IgG–driven complement-dependent cytotoxicity (CDC) is critical for the formation of NMO lesions, the molecular mechanisms governing ...
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Expression of aquaporin 4 in fast twitch fibers of mammalian skeletal muscle
... of aquaporin-4 (AQP4) in mammalian skeletal ...an aquaporin in skeletal muscle correlated to a specific fiber-type ...• aquaporin-4 • fast-twitch fibers • orthogonal arrays • Duchenne ...
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Neuromyelitis optica pathogenesis and aquaporin 4
... NMO-IgG. Aquaporin 4 (mainly the M23 variant) is expressed in ependyma and astrocytes in association with blood vessels or nerves [20,51] in both the gray and white matter of rat spinal cord [51,52] and in ...
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Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain
... mg/ml), 4 ml midazolam (5 mg/ml), ..., 4 mM K + , 130 mM Na + , 109 mM Cl - , 28 mM lactate), H:S pharmacy, Copenhagen University Hospital, Rigshospitalet, Copenhagen, ...
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Aquaporin-4 deletion ameliorates hypoglycemia-induced BBB permeability by inhibiting inflammatory responses
... Brain tissues were harvested from mice after hypoglycemic stress. Supernatants from the cerebral cortex were analyzed for cytokines. The production of cytokines by astrocytes is of particular interest because astrocytic ...
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Lung fluid transport in aquaporin 1 and aquaporin 4 knockout mice
... that aquaporin-type water channels facilitate osmotically driven and hydrostatically driven fluid transport between the airspace, interstitial, and capillary ...
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The role of aquaporin 4 in apoptosis after intracerebral hemorrhage
... For immunofluorescence staining, the following anti- bodies were used: mouse anti-NeuN (1:500; Millipore, Billerica, MA, USA) and rabbit anti-GFAP antibody (1:100; Millipore). Sections were incubated with primary ...
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Aquaporin 4: a player in cerebral edema and neuroinflammation
... In stroke pathophysiology, animals with a pre-existing inflammatory condition had aggravated stroke outcomes as seen by more edema and BBB damage at 24 h after injury compared to groups with no pre-existing inflam- ...
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