AR-V7
Detection of AR-V7 mRNA in whole blood may not predict the effectiveness of novel endocrine drugs for castration-resistant prostate cancer
... conducting AR-V7 assays in order to show that AR-V7 of tumor origin is actually ...of AR-V7 mRNA in cells in blood are very low, as a lot of cycles of amplification are often ...
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Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells
... analyze AR isoform- specific progression through ...in AR-V7 expressing cells. In particular, expression of AR- V7 corresponded to a statistically significant increase in glycolytic ...
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Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo
... variant AR-V7 plays a significant role in castration resistance, we further evaluated the efficacy of gal and VNPT55 in CRPC AR-V7 positive CWR22Rv1 ...
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Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells
... Since AR-V7 forms proteins complexes with PIP5K1α, we next investigated whether a decrease in AR- V7 expression induced by ISA-2011B might be a result of disruption of ...
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AR-v7 protein expression is regulated by protein kinase and phosphatase
... with AR and PI3K/Akt signaling ...to AR inhibition. AR-v7 is one among many other proteins, whose phosphorylation modification and protein expression is differentially ...of ...
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<p>Current status of liquid biopsies for the detection and management of prostate cancer</p>
... of AR-V7 in whole- blood RNA was also reported without the need for CTC ...detectable AR-V7 in whole-blood RNA, and the presence of AR-V7 was associated with poor response to ...
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The characteristics of androgen receptor splice variant 7 in the treatment of hormonal sensitive prostate cancer: a systematic review and meta-analysis
... that AR-V7 mRNA derived from circulating tumor cells (CTCs) may be a prognostic marker of novel hormonal therapy (NHT) resistance including Abiraterone and Enzaluta- mide [8–10], while could predict ...
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Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer.
... canonical AR exon 3, with inclusion of a cryptic exon 3b (CE3b) derived from an intron in the expressed protein ...[10]. AR-V7 expression is associated with a rearranged AR gene and can also ...
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Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer.
... examining AR-V7 cistromes and transcrip- tomes demonstrated proliferative cistomes/transcriptomes that are likely not specific to AR-V7 but a marker of rapidly progres- sive disease (23, ...
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Androgen receptor splice variant 7 expression emerges with castration resistance in prostate cancer
... the AR axis with AA and E has improved both overall survival and quality of life for patients with CRPC (10–17, ...ongoing AR activity and tumor ...active AR splice variants, of which ...
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Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer.
... CTC AR-V7 positivity to be associated with more advanced disease, we next determined whether this impacted survival analyses in an unselected cohort of 162 mCRPC patients (prognostication cohort; Supplemen- ...
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Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells
... Unfortunately, AR dysfunction means that resistance to enzalutamide will eventually ...truncated AR without changing their protein ...of AR and its CRPC-associated variant AR-V7 at ...
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Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer
... nuclear AR-V7 protein levels from HSPC to CRPC in our patient cohort, of which nearly all patients had received docetaxel and ...nuclear AR-V7. We hypothesise that while some tumours express ...
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Expression of androgen receptor splice variants in clinical breast cancers
... androgen, AR-V7 overexpression significantly altered transcript levels of 47 genes compared to the empty vector control (Supplementary Table ...stimulation, AR-V7 over-expression resulted in ...
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Novel molecular targets in advanced prostate cancer
... 160 order for a signal-generating “tree” to form at the target site (149). Single probes binding to nonspecific sites should not produce a full binding site for the pre-amplifier, thus preventing amplification of ...
304
Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer
... phase, AR is reactivated through several mechanisms, including AR amplification and mutation, as well as activation of AR through other sign- aling pathways ...Although AR is reactivated in ...
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Androgen receptor splice variants circumvent AR blockade by microtubule-targeting agents
... of AR-Vs are well recognized in resistance to hormonal therapies, evidence has just started to accumulate to support their involvement in resistance to taxane ...of AR- V7 in resistance to taxane ...
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Prostate cancer: AR aberrations and resistance to abiraterone or enzalutamide.
... genomic AR aberrations have been shown to associate with resistance to abiraterone or ...enzalutamide. AR variants lacking the ligand- binding domain (LBD) maintain AR-regulated transcription in ...
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A STUDY ON SPEAKING SKILL ACTIVITIES IN AR-ROHMAH ENGLISH COMMUNITY PROGRAM IN SMA AR-ROHMAH MALANG
... in Ar-Rohmah English Community Program in SMA Ar-Rohmah Malang, to find out the problems related to teaching and learning English speaking skill activities in AEC Program and to investigate the solutions ...
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Design of FPGA Routing Ar
... proach works as follows: first, a PathFinder-style rout o small groups of wire segments, called wide wires, ra y coarsening the routing resource (RR) graph, which ing stage assign[r] ...
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