Arg-Gly-Asp
Entactin stimulates neutrophil adhesion and chemotaxis through interactions between its Arg Gly Asp (RGD) domain and the leukocyte response integrin
... the Arg-Gly-Asp (RGD) domain in entactin, SIGFRGDGQTC (S-RGD), mediated PMN adhesion and chemotaxis, and preexposure of PMN to S-RGD blocked ...
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Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells.
... In flat adherent cells, virus mutants with amino acid substitutions in the RGD sequence were delayed in virus reproduction and in the onset of viral DNA synthesis.. In nonadherent or poo[r] ...
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Cell Recognition by Foot-and-Mouth Disease Virus That Lacks the RGD Integrin-Binding Motif: Flexibility in Aphthovirus Receptor Usage
... conserved Arg-Gly-Asp (RGD) motif responsible for integrin receptor ...a Asp-1433Gly change at the RGD motif was conditioned by a number of capsid substitutions selected upon FMDV evolution in ...
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Heterogeneous dimer peptide-conjugated polylysine dendrimer-Fe<sub>3</sub>O<sub>4 </sub>composite as a novel nanoscale molecular probe for early diagnosis and therapy in hepatocellular carcinoma
... pentapeptide (cyclo[-Arg-Gly-Asp-Phe-Lys]) (MW 603.7 Da), GX1 nonapeptide (cyclo[-Cys-Gly-Asn-Ser-Asn-Pro- Lys-Ser-Cys]) (MW 907 Da), and RGD-GX1 heterogeneous dimer peptide (MW 1927.8 Da) ...
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Use new PLGL-RGD-NGF nerve conduits for promoting peripheral nerve regeneration
... grafting Gly-Arg-Gly-Asp-Gly (RGD peptide) and nerve growth factor (NGF) for fabricating new PLGL-RGD-NGF nerve conduits to promote nerve regeneration and functional ...
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Fe<sub>3</sub>O<sub>4</sub>-based PLGA nanoparticles as MR contrast agents for the detection of thrombosis
... Abstract: Thrombotic disease is a great threat to human health, and early detection is particularly important. Magnetic resonance (MR) molecular imaging provides noninvasive imaging with the potential for early disease ...
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Self assembled HCV core virus like particles targeted and inhibited tumor cell migration and invasion
... We used a baculovirus expression system to express fusion proteins of HCV core, RGD (Arg-Gly-Asp) peptide, and IFN- α 2a fragments in Sf9 cells. Western blotting and electron microscopy demonstrate ...
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Point mutations within the betaG-betaH loop of foot-and-mouth disease virus O1K affect virus attachment to target cells.
... Virus attachment to specific cell surface molecules is the initial step of the infectious process and contributes to the understanding of FMDV infection cycle. In this work, the viral component involved in attachment of ...
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Index Catalog // Carolina Digital Repository
... used microbeads which were modified by minimum cell binding ligand of fibronectin, Arg-Gly-Asp (RGD), to induce integrin activation and formation of adhesion complex which included rec[r] ...
163
PLLA-PEG-TCH-labeled bioactive molecule nanofibers for tissue engineering
... 31 ENSs can be used to investigate tissue regeneration and stem cell modulation through the surface functionalization of different epitopes (eg, Arg-Gly-Asp, Pro-His-Ser-Ar[r] ...
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Cyclic RGD peptide-modified liposomal drug delivery system: enhanced cellular uptake in vitro and improved pharmacokinetics in rats
... In the present study, by covalently coupling a cyclic RGD, cyclo(Arg-Gly-Asp-D-Phe-Cys) (cRGDfC, abbreviated as cRGD) to the liposomal surface, we constructed PEGylated liposomes w[r] ...
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Tissue engineering of heart valves: PEGylation of decellularized porcine aortic valve as a scaffold for in vitro recellularization
... PEG: Poly (ethylene glycol); DAV: Decellularized porcine aortic valve; HE: Hematoxylin and eosin; SEM: Scanning electron microscopy; GRGDSPC: Gly-Arg-Gly-Asp-Ser-Pro-Cys; VEGF165: Vascul[r] ...
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Usage of Integrin and Heparan Sulfate as Receptors for Mouse Adenovirus Type 1
... 2831 Downloaded from http://jvi.asm.org/ on November 8, 2019 by guest Adenovirus fiber knobs are the capsid components that interact with binding receptors on cells, while an Arg-Gly-Asp[r] ...
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Novel functionalized nanoparticles for tumor-targeting co-delivery of doxorubicin and siRNA to enhance cancer therapy
... To obtain a combined effect of chemotherapeutic drug and siRNA, the positively charged RGDfC (Arg-Gly-Asp-D- Phe-Cys, tumor-targeting peptide) was coupled with the SeNPs to [r] ...
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M-Brucin, an antibacterial peptide against Staphylococcus epidermidis and Streptococcus pyogenes
... which is specific to S. pyogenes was chemically synthesized and its net charge was changed by deleting or replacing some negatively charge amino acids. Five modified peptides were designed (Table 2) and determined for ...
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Photodynamic therapy of a 2-methoxyestradiol tumor-targeting drug delivery system mediated by Asn-Gly-Arg in breast cancer
... Abstract: Fullerene (C60) has shown great potential in drug delivery. In this study we exploited modified fullerene (diadduct malonic acid-fullerene-Asn-Gly-Arg peptide [DMA-C60-NGR]) as an antitumor drug ...
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Adaptive evolution of fish hatching enzyme: one amino acid substitution results in differential salt dependency of the enzyme
... dependencies of HCEs are well adapted to each salinity at the time of hatching. Different from HCE, LCEs of both species maintained the activity sufficient for egg envelope digestion in various salinities. The difference ...
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Intragenic suppression of a capsid assembly-defective P22 tailspike mutation.
... From the analysis of the hmH3034 mutant and its suppressors, we propose that in the wild-type tailspike protein, the Asp residue at position 100 and the Arg residue at posit[r] ...
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EFFECT OF GLY 16 ARG SINGLE NUCLEOTIDE POLYMORPHISM ON AGONIST BINDING TO BETA 2 ADRENERGIC RECEPTOR – A STRUCTURAL PHARMACOGENOMIC APPROACH
... Active site prediction: The ligand binding domain of the human beta-2 adrenergic receptor and its variant bearing the Gly16Arg single nucleotide polymorphism were individually predicted [r] ...
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Evaluation of the ATB 32 A system for identification of anaerobic bacteria isolated from clinical specimens
... False-negative Arg-A, Phe-A, Leu-A, PyrA, and Gly-A False-positive a-ARA; false-negative ArgA, Leu-A, and Tyr-A Bacteroides oris not in data base Bacteroides splanchnicus not in data bas[r] ...
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