arginine methylation
Protein arginine methylation/demethylation and cancer
... of arginine methylation in cancer, the development and validation of such drugs in clinical trials may represent the next challenge in this field of ...for arginine methylation, protein ...
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Arginine Methylation of the ICP27 RGG Box Regulates the Functional Interactions of ICP27 with SRPK1 and Aly/REF during Herpes Simplex Virus 1 Infection
... by methylation on ar- ginine residues (10, 16). The major site of arginine methyl- ation, as determined by mass spectrometric analysis, is the RGG box from residues 138 to 152 ...Specifically, ...
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Arginine Methylation Increases the Stability of Human Immunodeficiency Virus Type 1 Tat
... 26). Arginine methylation by PRMT6 was recently shown to have a negative impact on the activities of HIV-1 Tat, Rev, and nucleocapsid proteins (5, 27, ...at arginine residues 52 and 53 and ...
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Regulation of the EBNA1 Epstein-Barr Virus Protein by Serine Phosphorylation and Arginine Methylation
... for methylation in vivo. Inhibition of methylation by MTA treatment did not produce an obvious effect on EBNA1 transcriptional activation or on its ability to attach to cellular chromosomes (a prereq- ...
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The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5- mediated p53 arginine methylation
... The fact that patients with Fanconi anemia (FA) gene mutations have high predisposition to leukemia and other cancers indicates that FA disease progression involves oncogenic transformation. Little is known about the ...
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Organization of Plasmodium falciparum spliceosomal core complex and role of arginine methylation in its assembly
... Splicing is a universal process present in all modern eukaryotic life and many of the components of splicing machinery seem to be conserved across the evolution [17]. A large number of studies performed in Xenopus laevis ...
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From arginine methylation to ADMA: A novel mechanism with therapeutic potential in chronic lung diseases
... Arginine methylation in pulmonary fibrosis Compared with the aforementioned available data on ADMA and vascular remodeling in PAH, much less is known about the role of methylated arginines in intersti- tial ...
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Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development
... maternally controlled early cell cycles in the absence of transcription. Histone post-translational modifications (PTMs) direct and regulate chromatin-templated transactions, so understanding the nature and function of ...
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Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region
... Arginine methylation of Tat diminishes Tat-TAR binding affinity and Tat-TAR-cyclin T1 complex formation. Pro- karyotes do not contain any PRMTs (12). Therefore, to test the FIG. 2. PRMT6 affects Tat ...
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Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3
... Knowledge about the precise molecular mechanisms underlying colorectal tumorigenesis is crucial to the development of better therapy strategy for CRC patients. The dysregulation of PRMTs has been observed in diverse ...
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Arginine Methylation of the RGG Box Does Not Appear To Regulate ICP27 Import during Herpes Simplex Virus Infection
... Arginine methylation has been shown to affect protein traf- ficking and protein interactions (2, ...that arginine methylation of ICP27 occurs primarily in the nucleus (30), which is in accord ...
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Arginine Methylation of Human Adenovirus Type 5 L4 100-Kilodalton Protein Is Required for Efficient Virus Production
... that arginine methylation can be a negative regulator of pro- tein-protein interactions (3, ...histone arginine demethylase located in the nucleus ...
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Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA
... of arginine methylation in SFPQ/PSF using mass spectrometry and found that several arginines in the N-terminal domain of SFPQ/PSF are asymmetrically ...protein arginine N-methyltransferase, PRMT1, ...
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Arginine Methylation of the ICP27 RGG Box Regulates ICP27 Export and Is Required for Efficient Herpes Simplex Virus 1 Replication
... that arginine methylation is im- portant for modulating protein-protein interactions (4, 9, 11, 19, ...by arginine methylation (3, 10, 19, 23, 34, 46, ...numerous arginine residues, ...
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Protein arginine methylation: an emerging regulator of the cell cycle
... on arginine residues [163–165]. Serine–arginine rich (SR) splicing factors are another prominent splicing fac- tor family [166] and it should come as no surprise that SR splicing factors are methylated due ...
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Arginine methylation of SmB is required for Drosophila germ cell development
... of arginine methylation in germline establishment and ...of arginine residues in the tail of SmB: the first group includes the three proximal arginine residues and is required for gonad ...
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Protein Arginine Methylation in Candida albicans: Role in Nuclear Transport
... mediate methylation-sensitive Npl3-Npl3 interaction in ...4C). Methylation and nucleocytoplasmic transport of Npl3 in ...The methylation sensitivity of Npl3 dimerization in ...of arginine ...
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Protein Arginine Methylation in Parasitic Protozoa
... posttranslational methylation of arginine residues in proteins affects myriad cellular processes, including transcription, RNA processing, DNA replication and repair, and signal ...protein arginine ...
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Critical Role for Arginine Methylation in Adenovirus-Infected Cells
... of arginine methylation on 100K, we searched for posttranslational modifications on the full- length protein by using reversed-phase LC-MS/MS analysis ...of methylation in the regulation of 100K ...
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PRMT6 increases cytoplasmic localization of p21 CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents
... the methylation-specific ...the methylation-specific antibody. Then we confirmed that the methylation signal was abolished in R156A-mutant p21 (Figure ...p21 methylation in vivo, we introduced ...
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