Arginine methyltransferase
pUL69 of Human Cytomegalovirus Recruits the Cellular Protein Arginine Methyltransferase 6 via a Domain That Is Crucial for mRNA Export and Efficient Viral Replication
... via arginine methylation within the functionally important N ...protein arginine methyltransferase 6 ...the arginine-rich R1 box of pUL69 that were crucial for PRMT6 and/or UAP56 ...harboring ...
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Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii
... protein arginine methyltransferase family (PRMT) shares a conserved methyltransferase domain with subdomains for binding to S-adenosyl- L-methionine (SAM), a methyl donor and substrate ...putative ...
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Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells
... arginine methyltransferase 5 ...at arginine 8 (H3R8) and histone 4 arginine 3 (H4R3), and is one of two “type II” argi- nine methyltransferases, the other being PRMT7 (Karkhanis et ...
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Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3
... Protein arginine methyltransferases (PRMTs) plays critical roles in ...survival. Arginine methyltransferase inhibitor 1 (AMI-1) strongly inhibited tumor growth, increased the ratio of Bax/Bcl-2, and ...
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Cellular localization of protein arginine methyltransferase-5 correlates with grade of lung tumors
... protein arginine methyltransferase 5 (PRMT5) has been shown to be involved in silencing of tumor suppressor genes promoting neoplastic transform- ...symmetric arginine methylation of histones and ...
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Protein arginine methyltransferase 1 is required for maintenance of normal adult hematopoiesis
... Protein arginine methyltransferase 1 (PRMT1) is the predominant asymmetric (type I) methyltransferase in mammalian cells. Mounting evidence suggested that PRMT1 is essential to embryonic development ...
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Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma
... protein arginine methyltransferase 1 (PRMT1), which identifies a subgroup of patients with high-risk ...methylated arginine R65 to alanine decreased MYCN stability by altering phosphorylation at ...
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<p>Protein Arginine Methyltransferase 4 Regulates Adipose Tissue Lipolysis in Type 1 Diabetic Mice</p>
... Protein arginine methyltransferase 4 (PRMT4), also known as coactivator-associated arginine methyltransfer- ase 1 (CARM1), converts the monomethylarginine inter- mediate to asymmetric ...
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Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression
... Recent evidence points to the protein arginine methyltransferase (PRMT) family of enzymes playing critical roles in cancer. PRMT7 has been identified in several gene expression studies to be associated with ...
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Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis
... protein arginine methyltransferase PRMT5 catalyzes the formation of symmetric dimethyl arginine and has been implicated in various cellular processes, including pluripotency and ...
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The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells
... protein arginine meth- yltransferase identified [29]. Most protein arginine methy- lation is catalyzed by PRMT1 ...methylates arginine residues flanked by one or more gly- cine residues ...protein ...
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4-23-2014 12:00 AM The role of the arginine methyltransferase CARM1 in global transcriptional regulation.
... Protein Arginine Methyltransferase (PRMT) family is responsible for histone arginine methylation, and also uses SAM as a ...at arginine 2 (H3R2) and histone H4 arginine 3 (H4R3) ...
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Upregulation of Protein Phosphatase 2Ac by Hepatitis C Virus Modulates NS3 Helicase Activity through Inhibition of Protein Arginine Methyltransferase 1
... activity. Arginine 467 in the helicase domain of NS3 (arginine 1493 in the polyprotein) can be methylated by protein arginine methyltransferase 1 ...
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Toxoplasma gondii Arginine Methyltransferase 1 (PRMT1) Is Necessary for Centrosome Dynamics during Tachyzoite Cell Division
... The arginine methyltransferase family (PRMT) has been implicated in a variety of cellular processes, including sig- nal transduction, epigenetic regulation, and DNA repair ...
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Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer
... cancer cells [33]. Our results indicate that R248 is the major residue methylated by PRMT3 in vivo, and R248 methylation enhances metabolic reprogramming and cellular proliferation of pancreatic cancer cells. R248 is ...
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TbPRMT6 Is a Type I Protein Arginine Methyltransferase That Contributes to Cytokinesis in Trypanosoma brucei
... In this article, we report the in vitro and in vivo character- ization of a PRMT from the protozoan parasite T. brucei. This enzyme, which we term TbPRMT6, is most similar to PRMT6 in the family of mammalian protein ...
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Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor-driven transcription of hepatic lipogenic genes in vivo
... LXR-dependent transcription of target genes occurs via the recruitment of co-repressors and co-activators (Perissi and Rosenfeld, 2005; Komati et al., 2017). The recruitment of these cofactors is cell type- and ...
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Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death
... of arginine methylation and divergent signal transduction ...Protein arginine methylation, together with phosphorylation, has been shown to be a major post-translational modification that occurs in ...
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SHARPIN mediated regulation of protein arginine methyltransferase 5 controls melanoma growth
... affect arginine methyla- tion of all histones, it does affect the expression of some gene networks, as demonstrated here for SOX10 and PAX3, through PRMT5-mediated methylation of R8 in the SKI repressor ...
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Arginine methyltransferase Capsuléen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila
... Although arginine modification has been implicated in a number of cellular processes, the in vivo requirement of protein arginine methyltransferases (PRMTs) in specific biological processes remain to be ...
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