Argonaute Proteins
Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements
... of Argonaute proteins in siRNA-based antiviral response in eukaryotes, (ii) the con- textual links between pAgos and nucleases (in particular, restriction endonucleases) that are involved in phage/ plasmid ...
15
Analysis and characterization of the genes encoding the Dicer and Argonaute proteins of Schistosoma japonicum
... all Argonaute proteins share the structural features of PIWI domains ...naute proteins are highly conserved between species, and many organisms encode multiple members of the family ...
8
The Expanded Universe of Prokaryotic Argonaute Proteins
... pAgo proteins, their strong association with genes encoding proteins involved in DNA processing suggests their common function and joint horizontal ...
20
Functional Characterization of Entamoeba histolytica Argonaute Proteins Reveals a Repetitive DR-Rich Motif Region That Controls Nuclear Localization
... Ago proteins (EhAgo2-1 [EHI_186850], EhAgo2-2 [EHI_125650], and EhAgo2-3 [EHI_177170]), three RNA-dependent RNA polymerases (RdRPs) (EHI_139420, EHI_179800, and EHI_086260), and one protein (EHI_068740) with a ...
19
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver
... In this regard, our results and models allow us to envision mul- tiple new avenues to concurrently improve the efficacy, safety, and persistence of future RNAi gene therapies in humans, especially those involving shRNA ...
15
Original Article Evaluation of Argonaute protein as a predictive marker for human clear cell renal cell carcinoma
... Abstract: Argonaute subfamily proteins are involved in human organ growth and ...the Argonaute proteins were assessed by im- munohistochemistry (IHC) in tissue microarrays (TMA), containing ...
9
An Argonaute-Like Protein Is Required for Meiotic Silencing
... aligned proteins (All) and among only the six fungal proteins (Fungi) are shown (see Table S3, electronic supplementary material at ...the proteins, organisms, and ...SMS-2-related proteins ...
8
Original Article Argonaute 2 is up-regulated in tissues of urothelial carcinoma of bladder
... 18]. Argonaute proteins are the essential components of RISC that directly recruit miR- NAs and function as the interface between miRNAs and their mRNA ...
8
Mammalian Argonaute-DNA binding?
... prokaryotic Argonaute proteins are able to bind DNA and to carry out DNA-guided as well as RNA- guided mediated cleavage of DNA molecules (“DNA interference”) ...eukaryotic Argonaute proteins ...
11
Investigation of the argonaute protein variants in Toxoplasma gondii and the contribution of argonaute to RNA silencing
... PIWI-like proteins, by contrast, may participate in the maturation of repeat-associated small interfering (rasi) RNAs and Piwi-interacting RNAs (piRNAs) in flies and mammals (Gunawardane et ...some ...
97
Ender, Christine (2009): Characterization of protein and small RNA components of Argonaute complexes. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... into Argonaute proteins which are the key components of ribonucleoprotein complexes (miRNPs), often referred to as RNA induced silencing complex ...Ago proteins and hAgo2 (Leuschner et ...Ago ...
128
RNA interference approaches for treatment of HIV-1 infection
... downstream proteins necessary for viral maturation, because the early proteins are required for production of late ...enzymatic proteins required for viral assembly and infection (including gag, pol, ...
16
Role of microRNAs in embryo implantation
... level by targeting mRNAs for cleavage or transcriptional repression [8, 9]. Synthesized in the nucleus, a long and stem-loop carried primary miRNA is processed by Dor- sha, a critical RNase III protein, to form a small ...
11
Inhibition of tumourigenicity of small cell lung cancer cells by suppressing Id3 expression.
... numerous conserved, cis-regulatory sequences which are typical in early-response genes, whose expression is associated with mitogenic third-messenger signalling cascades (316). It was found that Id1 promoter can be ...
252
High throughput sequencing of RNAs isolated by cross linking immunoprecipitation (HITS CLIP) reveals Argonaute associated microRNAs and targets in Schistosoma japonicum
... analyzed their expression level across the lifespan of S.japonicum [24, 28]. Subsequently, the same group demonstrated that miRNA-71a cluster and miRNA- 71b cluster were expressed in schistosomulum, using deep sequencing ...
11
Toxoplasma gondii Differentiation: Effects of Modifying Lactate Dehydrogenase and Argonaute Expression Patterns
... of argonaute in other organisms resulted in a large reduction of RNAi activity suggesting that argonaute plays a key role in RNAi (Durand-Dubief and Bastin, ...
129
The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members
... of proteins, and RNA helicases (reviewed by Ding and Han, 2007; Parker and Sheth, ...Other proteins concentrated in P-bodies include general mRNA translation repression and mRNA decay machinery ...
14
Beyond BLASTing : ribonucleoprotein evolution via structural prediction and ancestral sequence reconstruction
... different proteins; the Major Vault Protein whose monomers make up the enigmatic vault particle and the argonaute family of proteins (AGO and PIWI) that appear to have a major hand in quelling ...
11
Evolution of RNA- and DNA-guided antivirus defense systems in prokaryotes and eukaryotes: common ancestry vs convergence
... prokaryotic Argonaute (pAgo)-centered innate immunity and CRISPR-Cas adaptive immunity as well as diverse branches of RNA interference (RNAi) in ...Cas proteins that would get activated as a result of ...
14
Review of the RNA interference pathway in molluscs including some possibilities for use in bivalves in aquaculture
... In invertebrates, the functional presence of this interferon pathway is clouded. Using bioinformatical searches for the conserved N-terminal DNA binding domain of IRF and the C-terminal IRF association domain 1 or 2 ...
13