aromatase gene
No associations between aromatase gene polymorphisms and breast cancer risk in Saudi patients
... of ESR1, ESR2, CYP17A1, and CYP19A1 and the risk of breast cancer: a case control study from North India. Tumour Biol. 2014;35:4517–4527. 9. Fasching PA, Loehberg CR, Strissel PL, et al. Single nucleotide poly- morphisms ...
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Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
... of aromatase inhibitors is already a standardized treat- ment for postmenopausal breast carcinomas ...Physiologically, aromatase exists not only in gonadal tissues such as the ovary and placenta, but also ...
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Transforming growth factor-beta inhibits aromatase gene transcription in human trophoblast cells via the Smad2 signaling pathway
... CYP19 gene, is a key enzyme involved in estrogen biosynthesis ...CYP19 gene has 9 coding exons (exon II-X) and the 5' untranslated region is encoded by exon I which is alternatively used by different ...
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Correlation of rs749292 and rs700518 polymorphisms in the aromatase gene (CYP19A1) with osteoporosis in postmenopausal Polish women
... In this study, we observed no statistically significant effects of CYP19A1 polymorphisms on the occurrence of osteopenia and osteoporosis. No differences were not- ed in the distribution of the CYP19A1 rs749292 genotype ...
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POLYMORPHISM OF CYTOCHROME P450, SUPERFAMILY19, POLYPEPTIDE 1 GENE AND RELATED TO AROMATASE ENZYME ACTIVITY IN ACROMEGALY IRAQI PATIENTS
... the aromatase gene expression is regulated in a tissue promoter ...of aromatase activity leads to the degree of masculinization of the external genitalia was greater at birth in females that exposure ...
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Effect of aromatase inhibitor (fadrozole) on proliferation, estradiol production and telomerase activity in pig granulosa cells in vitro
... on aromatase gene ex- pression in long-term pig granulosa cell ...on aromatase expres- sion in granulosa cells in vitro was previously dem- onstrated in rats (Fitzpatrick and Richards, 1991; ...
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Bicalutamide and Third-Generation Aromatase Inhibitors in Testotoxicosis
... Aromatase is a cytochrome p450 en- zyme (CYP19) that catalyzes the con- version of C19 androgens to C18 estro- gens. The first individuals described with an identifiable aromatase gene defect were male ...
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Understanding the mechanisms of aromatase inhibitor resistance
... the aromatase gene and may have functional infl uences on the interaction between the enzyme protein, its substrate and inhibitors ...CYP19 gene may alter the eff ectiveness of AI therapy in the ...
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The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer
... (1) Aromatase (Arom) which converts androstenedione (A) to estrone (E1); (2) estrone sulfatase (E1-STS) which hydrolyses estrone sulfate (E1-S) to E1 and (3) estradiol-17 β - hydroxysteroid dehydrogenase (17 β ...
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Breeding Biotechnology, Sex Determination, and Growth in Southern Flounder, Paralichthys lethostigma
... Suppression of P450 aromatase gene expression in sex-reversed males produced by rearing genetically female larvae at a high water temperature during a period of sex differentiation in th[r] ...
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The emerging use of aromatase inhibitors for endometriosis treatment
... evaluating aromatase expression in endometriotic or endometrial tissue, a more recent in vitro study [15] supports the notion that aromatase is indeed expressed in endometriotic and endometrial cells from ...
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Estrogens and male reproduction
... At the same time, the development of a line of transgenic male mice lacking estrogen receptor (x, estrogen receptor I~ or aromatase gene provided further evidence [r] ...
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Use of aromatase inhibitors in practice of gynecology
... the aromatase enzyme in adipose tissue in obese women. Aromatase inhibitors prevent estrogen increase by inhibiting the aromatase enzyme in obese ...Since aromatase inhibitors are ...
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A case of Aromatase deficiency due to a novel CYP19A1 mutation
... closure and have osteoporosis due to impaired bone min- eralisation; these clinical features are comparable to those seen in patients with oestrogen receptor mutations; altered testis size and spermatogenesis may also be ...
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Aromatase inhibitors in post-menopausal endometriosis
... receiving aromatase inhibitor adjuvant therapy, and bisphosphonate therapy should be initiated when the Bone Mineral Density Measurement which is commonly reported in terms of T-score, are ...
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Clinical utilities of aromatase inhibitors in breast cancer
... Since aromatase has high specificity and is only involved in the last step steroid biosynthesis, inhibition of this enzyme does not affect levels of other biologically critical ...
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Aromatase inhibitor strategies in metastatic breast cancer
... Abstract: Despite ongoing therapeutic innovations, metastatic breast cancer (MBC) remains a treatable but incurable disease. In the developed world, a diagnosis of MBC without a preceding diagnosis of early stage disease ...
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Potential role of aromatase inhibitors in the treatment of endometriosis
... by aromatase pathways, standard management, such as GnRHas, which effectively downregulates ovarian E 2 biosynthesis, has little impact on extraovarian E 2 ...
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Role of Aromatase Inhibitor in Endometriosis
... years, aromatase inhibitors emerged in clinical use due to its ability to suppress aromatase which in turn reduced the production of ...of aromatase inhibitor in controlling the pain symptoms and ...
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Effects of the traditional Chinese medicine Yi Shen Jian Gu granules on aromatase inhibitor associated musculoskeletal symptoms: a study protocol for a multicenter, randomized, controlled clinical trial
... third-generation aromatase inhibitor (anastrozole, letrozole, or exemestane) and self-reported ongoing musculoskeletal symptoms (arthralgia and/or stiffness and/or swelling in one or more joints, bone pain, ...
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