Aromatase inhibitors
Aromatase inhibitors and risk of cardiovascular events in breast cancer patients: a systematic review and meta-analysis
... It is found that CV disease and breast cancer have several overlapping risk factors, such as obesity and smoking, meanwhile cardiovascular events (CVEs) is considered as one of the major causes of death in breast cancer ...
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Do aromatase inhibitors have adverse effects on cognitive function?
... Aromatase inhibitors are an important component of treatment for most postmenopausal women with hormone receptor-positive, early-stage breast ...taking aromatase inhibitors experience very low ...
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Aromatase inhibitors in men: effects and therapeutic options
... aromatase inhibitors such as aminoglutethimide are rela- tively weak and nonspecific; they can also block other steroidogenic enzymes necessitating adrenal steroid sup- ...Third-generation inhibitors ...
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The emerging use of aromatase inhibitors for endometriosis treatment
... expresses aromatase, an enzyme critical for estrogen production, emphasis has been placed upon the use of aromatase inhibitors for the treatment of endometriosis and its associated ...of ...
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Treatment of hormone positive uterine leiomyosarcoma with aromatase inhibitors
... AIs: Aromatase inhibitors; BSO: Bilateral salpingo-oophorectomy; CB: Clinical benefit; CBR: Clinical benefit rate (CR + PR + SD ≥ 6 months); CR: Complete response; CTCAE: Common Terminology Criteria for ...
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AROMATASE INHIBITORS: A NEW HOPE FOR BREAST CANCER PATIENTS
... selective Aromatase Inhibitors has offered an alternative approach for postmenopausal patients failing anti-estrogen therapy alone or other hormonal ...
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Molecular Docking Simulation Study of Novel Flavones and Flavonoids as Aromatase Inhibitors
... biosynthesis. Aromatase enzyme is essential for the estrogen ...an aromatase using (3EQM) PDB Id for the molecular docking ...known inhibitors against ...
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Bicalutamide and Third-Generation Aromatase Inhibitors in Testotoxicosis
... and, subsequently, first-generation aromatase inhibitors (AIs) (testolac- tone). Although these therapies are ef- fective in slowing growth velocity and reducing virilization, the risk of hepa- totoxicity ...
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The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment
... [467]. Aromatase enzyme deficiency and the use of aromatase inhibitors Obviously, aromatase (estrogen synthase) enzyme defi- ciency is associated with marked decrease or almost absence of ...
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Long-term safety of aromatase inhibitors in the treatment of breast cancer
... Abstract: Following promising data for metastatic breast cancer in terms of effi cacy and safety profi le, third-generation aromatase inhibitors (AI), anastrozole, letrozole, and exemestane, under- went a ...
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The Synthesis of Novel 7, 19-Bifunctional Androstenediones as Aromatase Inhibitors
... These aromatase inhibitors have potential use as therapeutic agents for estrogen-dependent ...these inhibitors take the same orientation as the ...the aromatase active center, (12) we have ...
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Aromatase inhibitors and antiepileptic drugs: a computational systems biology analysis
... Aromatase inhibitors have been especially useful for treating male patients with sexual or reproductive dysfunc- tion in addition to epilepsy [7]. They have also been pre- scribed clinically when the ...
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Endocrinology and hormone therapy in breast cancer: Aromatase inhibitors versus antioestrogens
... Recent clinical trials indicate that the new AIs generally have greater response rates and increase median time to progression compared with tamoxifen in patients with advanced breast cancer [9–12]. These studies ...
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Influence of CYP19A1 polymorphisms on the treatment of breast cancer with aromatase inhibitors: a systematic review and meta-analysis
... to aromatase inhibitors; NR, Not reported; OS, Overall survival; PFS, Progression-free survival; SNPs, Single- nucleotide polymorphisms; TTF, Time to treatment failure; TTP, Time to progression; UK, United ...
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Aromatase inhibitors in post-menopausal endometriosis
... Postmenopausal endometriosis is a rare clinical condition. The diagnosis and treatment of an endometriotic lesion in postmenopausal women is complicated. First line treatment choice should be surgical, given that there ...
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Bone loss and the aromatase inhibitors
... Very recently, the preliminary results of a study comparing adjuvant exemestane with placebo in low-risk breast cancer patients were presented by Lonning et al (2004). At 24 months, CTX had increased from baseline by 35% ...
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Effect of neuromuscular taping on musculoskeletal disorders secondary to the use of aromatase inhibitors in breast cancer survivors: a pragmatic randomised clinical trial
... Abbreviations AIA: AI- induced arthralgia; AIs: Aromatase Inhibitors; ATAC: Arimidex and tamoxifen alone or in combination; BADIX: Backache Disability Index; BAI: Back Pain Index; BC : B[r] ...
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Use of aromatase inhibitors in practice of gynecology
... symptoms. Aromatase enzime activitiy is located mainly in the ovary and is not detectable in normal endomet- rium and myometrium ...However aromatase en- zyme activity and increased expression of the ...
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Use of Aromatase Inhibitors in Children and Adolescents With Disorders of Growth and Adolescent Development
... with aromatase inhibitors is increasingly common, data for or against their use are extremely ...enzyme aromatase might prove beneficial to reduce clinical signs of estrogenization and/or ...
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Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review
... In conclusion, this systematic review suggests that AIs effectively reduce the severity of endometriosis-related pain symptoms. Since endometriosis is a chronic disease, future investigations should clarify whether the ...
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