Arrhythmias arising from the ischemic myocardium
Protective responses in the ischemic myocardium
... disability from ischemic heart disease to acceptable ...the myocardium. A greater understanding of the mechanisms of ischemic injury, and of endogenous defense mechanisms, could foster ...
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The myocardial microcirculation: A key target for salvaging ischemic myocardium?
... acute ischemic event are true collat- eral vessels or pre-existing arterioles/capillaries that open because of local changes in external influences on the myocardial wall independent of the vessels themselves is ...
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Altered distribution of lysosomal cathepsin D in ischemic myocardium
... nonsedimentable (i.e., 40,000-g supernate) activity developed by 30-45 min and increased further by 2 h. Simultaneously, the immunofluorescent localization of cathepsin D was also changed significantly. Within 30-60 min ...
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Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles
... In contrast, Xie et al, 28 in a partially analogous experimental setting, demonstrated extensive liver injury, ie, hepatocyte necrosis and mononuclear infiltration, accompanied by retention of the silica nanoparticles in ...
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Insulin like growth factor 1 protects ischemic murine myocardium from ischemia/reperfusion associated injury
... the ischemic myocardium was sup- ported by histologic evidence of improved tissue and cellular integrity, including markedly less interstitial edema around the perivascular ...model, ischemic ...
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Effects of ischemic preconditioning on ischemia/reperfusion-induced arrhythmias by upregulatation of connexin 43 expression
... Hearts of the rabbit were extracted and dried with a fil- ter. Specimens of left ventricular myocardium were then collected in the region supplied by the LAD for HE staining and cytological examination. Cx43 was ...
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Pharmacological and ischemic preconditioning of the human myocardium: mitoKATP channels are upstream and p38MAPK is downstream of PKC
... ventricular myocardium and the fact that this was a necrosis in vitro model, and therefore any extrapolation must be conducted with ...tained from patients subjected to various medical treat- ments such as ...
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CoQ10 enhances PGC1α and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium
... Data from this study taken together with the results of our clinical work suggests that while there may not be a detectable direct improve- ment in regional cardiac function following CoQ10 sup- plementation, ...
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Subendocardial contractile impairment in chronic ischemic myocardium: assessment by strain analysis of 3T tagged CMR
... Data Analysis Tag analysis was performed using the open source soft- ware Osirix inTag http://www.osirix-viewer.com with the sine-wave modeling method [11]. The sine-wave model method is based on simultaneous detection ...
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Relationship between the extent of non-viable myocardium and regional left ventricular function in chronic ischemic heart disease
... chronic ischemic heart disease and multi-vessel coronary artery ...chronic ischemic heart disease and 5 healthy volunteers underwent magnetic resonance imaging ( ...computed from short-axis delayed ...
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Targeting delivery of Radix Ophiopogonis polysaccharide to ischemic/reperfused rat myocardium by long-circulating macromolecular and liposomal carriers
... cardiac distribution Rats with myocardial ischemia were injected with each drug at the same molar dose of 4 μ mol/kg via the tail vein and were sacrificed at 0.167, 3, or 12 hours postdose. The hearts were harvested and ...
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Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway
... We found noteworthy alterations in PKB and ERK1/2 signaling in the different disease models. First, although the maximal activation of PKB/Akt can be achieved by IPostC in all three models, partial activation of PKB/Akt ...
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Ischemic postconditioning protects remodeled myocardium via the PI3K PKB/Akt reperfusion injury salvage kinase pathway
... We found noteworthy alterations in PKB and ERK1/2 signaling in the different disease models. First, although the maximal activation of PKB/Akt can be achieved by IPostC in all three models, partial activation of PKB/Akt ...
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Original Article Cell transplantation into ischemic myocardium using mesenchymal stem cells transfected by vascular endothelial growth factor
... from myocardial cells in their excitation con- traction coupling and mechanic properties, so it is difficult to establish an excitation contraction coupling between the donor satellite cells and recipient ...
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Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium
... J Clin Invest. 1978;62(3):546-553. https://doi.org/10.1172/JCI109159. Lysophosphoglycerides, products of membrane phospholipid catabolism known to influence membrane function in several systems, appeared in the effluents ...
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Complement Localization and Mediation of Ischemic Injury in Baboon Myocardium
... Although there was no significant difference in the creatine kinase content of the normal sites between group I and II, there was significantly less creatine kinase depletion in the infa[r] ...
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Evidence for adenosine mediation of atrioventricular block in the ischemic canine myocardium
... oxygen-deprived myocardium can rise to 10- 100 microM concentrations known to cause atrioventricular (AV) conduction delay and ...in ischemic AV conduction ...
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MORPHOLOGICAL BASES OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE
... Abstract. This article presents pathomorphological changes of the atrioventricular part of the conducting system of the heart in patients with chronic ischemic heart disease followed by comparison of the results ...
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Effects of Catecholamines, Exercise, and Nitroglycerin on the Normal and Ischemic Myocardium in Conscious Dogs
... The effects of isoproterenol, norepinephrine, dobutamine, exercise, and nitroglycerin on left ventricular diameter, pressure, velocity of shortening, d P /d t , d P /d t / P , arterial p[r] ...
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Long Term Preservation of Ischemic Myocardium after Experimental Coronary Artery Occlusion
... J Clin Invest. 1978;61(3):541-551. https://doi.org/10.1172/JCI108965. The results of experiments with indirect methods have suggested that various interventions reduce infarct size after coronary artery occlusion. To ...
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