Arsenic trioxide (ATO)
Arsenic trioxide inhibits EBV reactivation and promotes cell death in EBV positive lymphoma cells
... Background: Epstein-Barr Virus (EBV) is associated with hematopoietic malignancies, such as Burkitt ’ s lymphoma, post-transplantation lymphoproliferative disorder, and diffuse large B-cell lymphoma. The current approach ...
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Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres
... Our group recently identified one mechanism of cellular resistance to Notch pathway inhibition in GBM: direct upregulation of the Hedgehog pathway through a novel cross talk mechanism. This involved constitutive sup- ...
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Antiosteogenic effect of arsenic trioxide, cholecalciferol, lovastatin or their combination in vitro
... pathway, arsenic trioxide (ATO), lovastatin (Lov) and cholecalciferol (vitamin D) impede differentiation of mesenchymal stem cells (MSC) into osteo- blasts or ...
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The effect of nilotinib plus arsenic trioxide on the proliferation and differentiation of primary leukemic cells from patients with chronic myoloid leukemia in blast crisis
... Previous studies have shown that the specific tyrosine kin- ase inhibitor imatinib (STI571) [4] and nilotinib (AMN107, trade name Tasigna) [5] are approved for the treatment of CML-AP or CML-BC patients. The ...
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Arsenic trioxide-based therapy in relapsed/refractory multiple myeloma patients: a meta-analysis and systematic review
... relapse. Arsenic trioxide (ATO) is the most active single agent in acute promyelocytic leukemia, the antitumor activity of which is partly dependent on the production of reactive oxygen ...
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Consolidation therapy of arsenic trioxide alternated with chemotherapy achieves remarkable efficacy in newly diagnosed acute promyelocytic leukemia
... with arsenic trioxide (ATO) therapies are considered the standard induction therapy regimens for adult patients newly diagnosed with acute promyelocytic leukemia ...
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Synergistic Effects of Arsenic Trioxide and Radiation: Triggering the Intrinsic Pathway of Apoptosis
... Background: Arsenic trioxide (ATO) has been reported as an effective anti-cancer and a US Food and Drug Administration (FDA) approved drug for treatment of some ...
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Inhibition of SHH pathway mechanisms by arsenic trioxide in pediatric medulloblastomas: a comprehensive literature review.
... New strategies for the treatment of MB are being explored. The SHH pathway and its components, PTCH1, SMO, and SUFU, were first investigated in an attempt to develop a specific drug for the blockade of these pathways. ...
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Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo
... All protocols for animal studies were approved by the Institutional Animal Care and Use Committee of Tulane University. C57/BL6 mice (Charles River) were separated into 5 groups with 7 mice in each group. Two days be- ...
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Original Article Silencing of HMOX1 enhances apoptosis caused by arsenic trioxide in HCC
... Abstract: Arsenic trioxide (ATO) is an effective commercial chemotherapeutic drug used to treat different cancers. ATO can induce apoptosis in cancer cells by causing the accumulation of intracellular ...
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Synergistic killing effects of homoharringtonine and arsenic trioxide on acute myeloid leukemia stem cells and the underlying mechanisms
... and arsenic trioxide (ATO) have been traditionally used in the treatment of AML in China separately; however, little is known about the effects of their ...
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Vitamin D3 potentiates the antitumorigenic effects of arsenic trioxide in human leukemia (HL-60) cells
... Acute promyelocytic leukemia (APL) is a subtype of the acute myeloid leukemia (AML). APL is characterized by abnormal, heavily granulated promyelocytes, a form of white blood cells. APL results in the accumulation of ...
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Arsenic trioxide and all trans retinoic acid (ATRA) treatment for acute promyelocytic leukemia in all risk groups: study protocol for a randomized controlled trial
... Background: The treatment of acute promyelocytic leukemia (APL) has been revolutionized in the past two decades by the advent of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). It suggests that ...
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Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway
... Arsenic Trioxide (ATO) has shown remarkable efficacy for the treatment of multiple myeloma (MM). However, the mechanism by which ATO exerts its inhibitory effect on the proliferation of myeloma cells ...
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Synergistic anti-tumor effects of arsenic trioxide and blue LED irradiation on human osteosarcoma
... Arsenic trioxide (ATO) has been well recognized as an anti-tumor agent for various human cancers. Recently, the blue light emitting diodes (LEDs)-based therapy has also been demonstrated to be potential ...
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A review of arsenic trioxide and acute promyelocytic leukemia.
... Arsenic trioxide (ATO) is very potent as a single agent against acute promyelocytic leukemia (APL). This old drug was reintroduced into new medicine by Chinese studies on APL treatment and rapidly approved ...
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“Possible Therapeutic Effect of Arsenic Trioxide and L-carnitine on Hepatocellular Carcinoma Induced in Rats” by Basma Z. Emam, Amira M. Abo-Youssef, Ahmed H. Osman, Aziza M. Amer, Basma Z. Emam, Egypt.
... Photomicrographs of rat liver sections stained with hematoxylin and eosin A: Normal control group (showing normal hepatic lobule). B-D: Carcinogenic control group (B: showing fatty degeneration with eccentric nuclei. C: ...
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Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002
... Human colon carcinoma cell line HCT116 and HT29 were purchased from the American Tissue Culture Collection (Manassas, VA, USA) and maintained at 37 ° C in complete Dulbecco’s Modified Eagle’s medium/F12 (Gibco, Grand ...
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Arsenic trioxide induces apoptosis and the formation of reactive oxygen species in rat glioma cells
... of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML ...
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Cytotoxicity patterns of arsenic trioxide exposure on HaCaT keratinocytes
... Arsenic trioxide (arsenic trioxide dissolved in dilute nitric acid, 1 mL = 1 mg AS; Reference Standard Solution, 1000 ppm + / − 1%/certified, ...previous arsenic exposure ( + AS = with ...
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