Artemisinin-Based Combination Therapies
Estimating antimalarial drugs consumption in Africa before the switch to artemisinin based combination therapies (ACTs)
... to artemisinin-based combination therapies (ACTs) as now recommended by the World Health Organization (WHO) ...ments based on cost of drugs, while acknowledging that other costs are ...
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Subsidizing artemisinin-based combination therapies: a preliminary investigation of the Affordable Medicines Facility – malaria
... The Affordable Medicines Facility – malaria (AMFm) is a financing mechanism hosted by The Global Fund to Fight AIDS, Tuberculosis and Malaria (GF) and designed to expand access to the best malaria treatments, which at ...
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Anti-malarial prescribing practices in Sudan eight years after introduction of artemisinin-based combination therapies and implications for development of drug resistance
... Recently, artemisinin resistance has been observed in four Southeast Asian countries (Cambodia, Myanmar, Thailand, and Viet Nam) ...of artemisinin monotherapies, and inadequate access to quality assured ...
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A pharmacy too far? Equity and spatial distribution of outcomes in the delivery of subsidized artemisinin based combination therapies through private drug shops
... Finally, qualitative interviews with shop owners and wholesale distributors were conducted in November 2008 following the pilot program to contextualize the quantitative results. Thirty-four DLDB storeowners and four ...
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Predicting Global Fund grant disbursements for procurement of artemisinin based combination therapies
... and artemisinin cultivation must predict demand for ACT on a product- and dosage-specific ...and artemisinin require- ments, may be performed using information contained in Global Fund proposals specifying ...
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Efficacy of non artemisinin and artemisinin based combination therapies for uncomplicated falciparum malaria in Cameroon
... AS-MQ combination has been widely used in some Southeast Asian countries to treat multidrug-resistant ...AS-MQ combination con- ducted in children aged > 5 years old and adults in Africa suggested its ...
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<p>High adherence level to artemisinin-based combination therapies in rural settlement 11 years after their introduction in the health system, Nanoro, Burkina Faso</p>
... address this gap by evaluating adherence level of patients to ACTs and factors associated with nonadherence in patients attending public health facilities in rural setting of Burkina [r] ...
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A clinical tool to predict Plasmodium vivax recurrence in Malaysia
... is based on the 52-week calendar. Severity was defined based on the WHO categories of non-severe and severe [11, ...primaquine combination therapy (chloroquine or artemisinin-based ...
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RECONSTITUTION OF ORAL ANTIMALARIAL SUSPENSIONS: AN UNRECOGNIZED FACTOR IN ANTIMALARIAL DRUG RESISTANCE
... the Artemisinin-based combination therapies (ACTs) in uncomplicated malaria infection, but the tablets are not recommended for children who weigh less than 5 kg, this makes it imperative that ...
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Assessment of the effect of larval source management and house improvement on malaria transmission when added to standard malaria control strategies in southern Malawi: study protocol for a cluster randomised controlled trial
... ACT: Artemisinin-based combination therapies; Bti: Bacillus thuringiensis israelensis; CBO: Community-based organisations; CDC: Centers for Disease Control and Prevention; COMREC: ...
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Willingness to use a rapid diagnostic test for malaria in a rural area of central Côte d'Ivoire
... Malaria is still an important public health problem in sub-Saharan Africa and elsewhere in the developing world [1]. Children under the age of five years and preg- nant women are the most vulnerable groups [2]. Mor- ...
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ANTI-MALARIAL TREATMENT: THEN; NOW AND FUTURE ASPECTS
... that artemisinin resistance will spread or develop independently around the ...in combination with other, longer-acting antimalarial ...first-line artemisinin-based combination ...
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The tolerability of single low dose primaquine in glucose 6 phosphate deficient and normal falciparum infected Cambodians
... to artemisinin-based combination therapies (ACTs) for blocking the transmission of Plasmodium falciparum in sick patients, few countries have introduced SDLPQ in their treatment ...
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Neuroauditory Toxicity of Artemisinin Combination Therapies—Have Safety Concerns Been Addressed?
... Although artemisinin-based combination therapies (ACTs) are widely viewed as safe drugs with a wide therapeutic dose range, concerns about neuroauditory safety of artemisinins arose during ...
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Efficacy of three artemisinin combination therapies for the treatmentof uncomplicated Plasmodium falciparum malaria in the Republic of Congo
... enrolled). The population of Kindamba Health Zone was estimated at 20,000 but has increased with the improving security situation. Malaria tends to be holo-endemic the whole year through. The season for malaria is ...
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A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivation
... possible mechanism related to ART resistance due to sev- eral connections between an autophagy-like pathway in P. falciparum and known mechanisms of ART action and resistance [15]. Indeed, ART can damage cells by ...
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Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials
... Compared to non-artemisinin antimalarials, ACT signifi- cantly reduced the gametocyte AUC during follow up (ratio of means 0.35 95% CI 0.31–0.41, Figure 2a), game- tocyte prevalence on day of feeding (OR 0.20 95% ...
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Stabilizing supply of artemisinin and artemisinin based combination therapy in an era of wide spread scale up
... data, global forecasts are often based on an intention to procure or projections of donor funds available rather than actual purchases. New initiatives such as the UNITAID-funded ACT forecasting consortium have ...
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From chloroquine to artemisinin based combination therapy: the Sudanese experience
... Federal Ministry of Health (FMOH) in decisions related to first-line treatment of malaria, in view of available data about CQ resistance. The TAC is constituted of 40 mem- bers, representing clinicians, pharmacists, ...
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Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin based combination therapy with primaquine
... [7]. Artemisinin-based combination therapy (ACT) is emerging as the best option in this context, particularly in settings where there are concerns about chloroquine- resistant ...in ...
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