arterial remodeling
Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling
... vascular remodeling at early age ...vascular remodeling was observed, the endothelial specific PHD2KO mice in our laboratory had a lower mortality and were able to survival after 15 ...
14
The oral glucose tolerance test-derived incremental glucose peak is associated with greater arterial stiffness and maladaptive arterial remodeling: The Maastricht Study
... stimulate arterial remodeling to increase arterial wall thickness ...maladaptive arterial remodeling of the carotid artery, as has previously been demonstrated in patients with type 2 ...
12
Brain Large Artery Lymphocytic Inflammation and Human Immunodeficiency Virus-Related Brain Arterial Remodeling
... brain arterial remodeling that potentially contrib- utes to HIV-related vasculopathy and ...brain arterial remodeling that may con- tribute to HIV-related cerebrovascular ...
10
Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
... impairment of HO-1 [30,31]. Further more, it has been recently shown, that stimulation of HO-1 induces an improvement of endothelial dysfunction in sponta- neously hypertensive Wistar-Kyoto rats by reducing OS and ...
17
Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1
... Methods and Results-Co-immunoprecipitation assay demonstrated that SIRT1, via its amino-terminus, binds to the DOC domain of HERC2 [HECT and RLD domain containing E3 ubiquitin protein ligase 2], which then ubiquitinates ...
17
Original Article Transfer of human hepatocyte growth factor reduces inflammation and prevents pulmonary arterial remodeling in monocrotaline-induced pulmonary arterial hypertensive rats
... Abstract: Inflammation and endothelial dysfunction contribute to the pathogenesis and development of pulmonary arterial hypertension (PAH). This study was to investigate the therapeutic effect of human hepatocyte ...
7
Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy
... Analysis of Variance was performed using StatView soft- ware (Version 5.0.1, SAS Institute, Cary, NC), to deter- mine diet (iron deficient vs. control) and duration (1 week vs. 1 month) effects. Paired t-tests were ...
10
A Study on Carotid Arterial Remodeling in patients with Obstructive Coronary Artery Disease and Disease Free Subjects.
... boundary between the media and the adventitia. This interface is well depicted by ultrasound. With increasing age, this pattern has been shown to thicken in a uniform way in straight arterial segments. Thickening ...
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Molecular Mechanisms of Pulmonary Arterial Remodeling
... monary arterial hypertension, a random- ized, efficacy study) showed that ima- tinib improved exercise capacity and hemodynamics in patients with ad- vanced PAH who remained sympto- matic on at least two drugs of ...
11
Ultrasound study of carotid and cardiac remodeling and cardiac arterial coupling in normal pregnancy and preeclampsia: a case control study
... spiral arterial remodeling, and aortic arterial stiffen- ing, have been extensively investigated ...carotid remodeling and arterial stiffening occurred in preeclampsia ...elastic ...
8
Prolonged activation of IL-5–producing ILC2 causes pulmonary arterial hypertrophy
... There is increasing experimental evidence that allergic conditions and eosinophilia are involved in the induction of arterial remodeling. In animals, persistent pulmonary allergic responses induced by house ...
12
Changes in Coronary Perfusion after Occlusion of Coronary Arteries in Kawasaki Disease
... curred in less than 2 years after CABG. Therefore, we rec- ommend regular follow-up CAGs until 2 years after CABG. Also, natural progression of RCA occlusion from severe stenosis could not be excluded because all RCAs ...
7
Sphingosine kinase1 : a potential therapeutic target in pulmonary arterial hypertension?
... also used a pharmacological inhibitor of S1P synthesis, SKi (SKI-II, 4-[[4-(4- chlorophenyl)-2-thiazolyl]amino]-phenol) [17], which inhibits both SphK1 and SphK2 activity. When administered to rats (10 mg/kg body weight, ...
36
Original Article Mesenchymal stem cells suppress lung inflammation and airway remodeling in chronic asthma rat model via PI3K/Akt signaling pathway
... way remodeling could be through a PI3K/Akt ...airway remodeling and also ...airway remodeling and inflammation in asthma through induction of the production of IL-6 and calponin and α-smooth muscle ...
10
Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension
... in PAH [21, 45], while in the intra-acinar arteries there was a reduction in medial hypertrophy and concentric laminar intimal thickening. Similar results were observed after MSC therapy in atherosclerosis lesions [46]. ...
15
The protective effects of ginsenoside Rg1 against hypertension target organ damage in spontaneously hypertensive rats
... Background: Although a number of medicines are available for the management of hypertension, the organ damage induced by hypertension is not resolved. The aim of this study was to investigate the protection of ...
9
<p>eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats</p>
... pulmonary arterial tissue and hypoxic-treated PASMCs proliferation, and all of these effects were inhibited by eIF2 α ...pulmonary arterial tissue was signi fi cantly increased in monocrotaline-induced PAH ...
11
Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes
... technical difficulty and expense involved, global transcriptional variation has been far less studied than genomic variation in bac- terial pathogens. Moreover, since the data corresponding to the groups of samples ...
14
Dynamic Remodeling of the Magnetosome Membrane Is Triggered by the Initiation of Biomineralization
... Finally, the coordination of membrane growth with the on- set of biomineralization implies that the size of the organelle is crucial in the development of its final product. It is possible that restricting the volume of ...
9
Chronic allograft rejection: A significant hurdle to transplant success
... There are two major hypotheses concerning the initiation of vascular remodeling and inflammatory response. Traditional concept called the “inside-out” response assumes that the inflammatory response to various ...
8