Articular chondrocyte
Original Article Study on regulation of articular chondrocyte proliferation and apoptosis in rabbit models with berchemia lineata massage cream by scrapping
... Abstract: Objective: To explore the influence of scrapping with berchemia lineata massage cream on the regula- tion of articular chondrocyte proliferation and apoptosis in rabbit models. Methods: A total of ...
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Original Article Expression profile of long noncoding RNA (HOTAIR) and its predicted target miR-17-3p in LPS-induced inflammatory injury in human articular chondrocyte C28/I2 cells
... human articular chondrocyte C28/I2 cells in a concentration-dependent ...human articular chon- drocyte C28/I2 cells treated with LPS, both the mRNA expressed and the amount of inflamma- tory ...
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A novel method to detect articular chondrocyte death during early stages of osteoarthritis using a non invasive ApoPep 1 probe
... the articular cartilage ...the articular cartilage but ApoPep-1 penetrated deep into the cartilage matrix despite being injected in vivo before preparation for ...
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Hypoxia HIF mediated articular chondrocyte function: prospects for cartilage repair
... All three HIF-targeting prolyl hydroxylases (PHD1/2/3) have been detected in the maturing zone of the mouse growth plate [57]. PHD2 was shown by Pouyssegur and colleagues to be dominant hydroxylase regulating HIF-1 α ...
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Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism
... of chondrocyte death is repeatedly ...cause chondrocyte cell death and can even be protective under certain con- ditions of oxidative stress ...[37]. Chondrocyte cell death from NO occurs under ...
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Antifungal Effect of Flavonoid Extract of Trachyspermum Ammi Plant on the Gene Expression of Pro-inflammatory Cytokines such as IL-18 and TNF-α in Articular Chondrocyte Cells
... cells Articular chondrocytes were isolated from the radiocarpal joints of mature Holsteins by digestion of the tissue with typeII collagenase (220U/ml, GIBCO, USA) for 12-18 h at 37 ...USA). Chondrocyte ...
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Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling
... mineralized articular cartilage detected from 9 weeks of age (Bertrand et ...the articular cartilage is caused simply by deposition of hydroxyapatite on the articular surfaces, or whether there is ...
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Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders
... is, articular chondrocyte proliferation, the expression of hypertrophy markers (for example, MMP-13 and collagen X), remodeling of the cartilage matrix by proteases, vascularization and focal calcifi - ...
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Mechanical signals control SOX 9, VEGF, and c Mycexpression and cell proliferation during inflammation via integrin linked kinase, B Raf, and ERK1/2 dependent signaling in articular chondrocytes
... Figure 1 Mechanical signals upregulate articular chondrocyte (AC) proliferation via SOX-9, VEGF, and c-Myc mRNA expression and ERK1/ 2 activation. ACs were exposed to no treatment or to treatment with ...
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Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration
... AC: Articular chondrocyte; ACAN: Aggrecan; AF: Annulus fibrosus; α -MEM: Minimum essential medium Eagle, alpha modification; CD: Chondrodystrophic; COL1A1: Collagen, type I, α 1; COL2A1: Collagen, type II, ...
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Protein kinase C delta null mice exhibit structural alterations in articular surface, intra articular and subchondral compartments
... Fiber optic laser scanning confocal microscopy (FOLSCM; Optiscan Pty Ltd, Melbourne, Australia) uses an optic fiber to deliver laser to a region of interest (ROI) of a specimen stained fluorescently [16]. The fluorescent ...
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Inhibitory function of parathyroid hormone related protein on chondrocyte hypertrophy: the implication for articular cartilage repair
... human articular chondrocytes under chondrogenic induc tion could promote chondrogenesis and inhibit hyper trophy of the engineered cartilage ...in chondrocyte- conditioned medium, hypertrophy was signifi ...
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C/EBP homologous protein drives pro catabolic responses in chondrocytes
... UPR activation and function in OA pathogenesis are not well understood. Moreover, prior function analyses of XBP1 and CHOP in chondrocytes or chondrocytic cell lines have been limited to date [13,15,16]. Hence, we ...
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Calcium deposition in osteoarthritic meniscus and meniscal cell culture
... Osteoarthritis (OA) is a disease characterized by the breakdown of hyaline articular cartilage and the forma- tion of osteophytes. A gradual realization, however, is that OA is not merely a cartilage disease, but ...
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Catabolic stress induces expression of hypoxia inducible factor (HIF) 1α in articular chondrocytes: involvement of HIF 1α in the pathogenesis of osteoarthritis
... modulates the process of chondrocyte proliferation, differenti- ation, and growth arrest in growth-plate chondrocytes [26]. More recently, Coimbra and colleagues also showed that HIF- 1 α is expressed in cultured ...
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Differential Chondrocyte Gene Expression Subsequent to In Vitro Shear and Axial Impactions in an Articular Cartilage Injury Model of Osteoarthritis.
... The aim of this study was to study gene expression changes following impact injuries to articular cartilage. Patellae were removed from porcine knee joints and were given one of three treatments: a primarily ...
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Nitric oxide-associated chondrocyte apoptosis in trauma patients after high-energy lower extremity intra-articular fractures
... of chondrocyte cell death due to NO-induced apoptosis compared to other causes of both immediate and delayed cell death as well as deter- mining the viability of remaining chondrocytes to ...
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Periodic mild heat stimuli diminish extracellular matrix synthesis in pellet cultured human chondrocytes
... Articular cartilage (AC) defects caused by factors such as trauma lead to pain, malfunction, and eventual onset osteoarthritis. Unfortunately, AC cannot regenerate spontaneously; therefore, several treatments have ...
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Cartilage extraceullular matrix derived scaffolds for joint regeneration
... Articular cartilage it is a highly specialised anisotropic tissue that functions to support joint contact forces and to reduce friction within the joint [85, 382]. Regenerating this complex tissue is still a ...
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Characterization of polydactyly-derived chondrocyte sheets versus adult chondrocyte sheets for articular cartilage repair
... Articular cartilage is composed mainly of hyaline cartil- age, which exhibits viscoelastic properties. Because of its low cellularity and avascular nature, its capacity to self- regenerate after injury or ...
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