Articular Chondrocytes
The new IL 1 family member IL 1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes
... Six novel members of the IL-1 family of cytokines were recently identified, primarily through the use of DNA database searches for IL-1 homologues, and were named IL-1F5 to IL-1F10. In the present study, we investigated ...
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Gold Nanoparticles of Diameter 13 nm Induce Apoptosis in Rabbit Articular Chondrocytes
... rabbit articular chondrocytes were pre-incubated with 3, 13, and 45 nm AuNPs, respectively, for 24 ...in chondrocytes, which must be seriously considered when using AuNPs for treatment of ...
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CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitromodel
... human articular chondrocytes have been described in detail ...human articular chondrocyte monolayer were placed in a sealed pressure chamber with inlet and outlet ...
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Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages
... on chondrocytes has mainly been investigated with regard to the cell biosynthetic activity, without considering and exploring chondrocyte catabolic ...human articular chondrocytes (HAC), and on their ...
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UDP glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis
... human articular chondrocytes in the late phase, which also modulated gene expression of Sp1, Sp3 and c-Krox and increased both Sp3/Sp1 and c-Krox/Sp1 ...of articular chondrocytes, while the ...
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Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes
... primary chondrocytes do not maintain their phenotype when cultured for a prolonged ...When chondrocytes dedifferentiate in monolayer culture they decrease proteoglycan synthesis and switch to production of ...
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CD147 (Extracellular Matrix Metalloproteinase Inducer-EMMPRIN) Expression by Human Articular Chondrocytes
... cells. Chondrocytes, cells of articular cartilage, express integrins and these molecules appear to have a variety of roles including ...human articular cartilage and identify potential roles in ...
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Pravastatin suppresses matrix metalloproteinase expression and activity in human articular chondrocytes stimulated by interleukin-1β
... We did notice that a clear dose response was seen in the down-regulation of MMP-9 expression, but we failed to detect a similar dose response with MMP-3. Although we do not have a good explanation for this, it may be ...
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α5β1 integrin induces the expression of noncartilaginous procollagen gene expression in articular chondrocytes cultured in monolayers
... Human articular chondrocytes were cultured in a monolayer for 2 or 7 days, and cell attachment was eval- uated using noncoated plates or plates coated with BSA or fibronectin, a known ligand to α5β1 ...of ...
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The effect of oxygen tension on calcium homeostasis in bovine articular chondrocytes
... matrix, articular cartilage is hypoxic compared to other tissue types ...consequence, articular chondrocytes have few mitochondria and metabolism is largely anaero- ...Notwithstanding, ...
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Exosomes from IL 1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes
... in articular chondrocytes, exosomes from IL-1β-stimulated SFB also induced the OA-like gene expression patterns, and they stimulated proteogly- can release from cartilage ...
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Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling
... of articular chondrocytes of synovial joints needs to be maintained throughout ...the articular cartilage, frequently associated with chondrocyte hypertrophy and calcification, is a central feature ...
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Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro
... Pro-inflammatory cytokines produced from activated synoviocytes and articular chondrocytes promote degra- dation of extracellular matrix components [21, 22]. Several lines of evidence suggest that ...
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Oxygen and pH-sensitivity of articular chondrocytes
... regarding articular chondrocytes, although reduction in all SOD isoform levels and GSH levels in human OA cartilage has been demonstrated (Scott et al, 2012; Regan et al, ...
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Human articular chondrocytes express 15 lipoxygenase 1 and 2: potential role in osteoarthritis
... in articular chondrocytes ...in chondrocytes is critical to our understanding the pathogenesis of OA and may lead to the development of new therapeutic targets for the treatment of the ...
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The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes
... in chondrocytes sub- jected to mechanical compression ...Normal chondrocytes reside in a hyperosmolar environ- ment (350 to 480 mOsm/L), which is reduced in well- established osteoarthritis (OA) to 280 to ...
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Co expression of 1α hydroxylase and vitamin D receptor in human articular chondrocytes
... human articular chondrocytes established in different experimental con- ditions comprising native tissue, suspension cultures, ad- herent cells/monolayer cultures and 3D spheroids ...that ...
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Millicurrent stimulation of human articular chondrocytes cultivated in a collagen type I gel and of human osteochondral explants
... not found in normal adult articular chondrocytes. It is strongly induced by the action of Il-1b [24]. In the pre- sence of soluble IL-6 receptor, IL-6 has been shown to activate osteoclasts to induce bone ...
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Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes
... of articular chondrocytes treated with exogenous GS and/or ...human chondrocytes in basal conditions [13,14] and also under IL-1β stimulation ...
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Calcium Homeostasis in Articular Chondrocytes of Two Different Animal Species
... Due to a lack of human tissue availability, when investigating the physiology or pathophysiology of articular chondrocytes, it is necessary that appropriate ani- mal models are used for comparative studies. ...
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