Aryl hydrocarbon receptor activity
Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma
... Figure 2. CLF is an AHR antagonist. (A) Extracts of WI38 cells treated for 2 hours with increasing concentrations of CLF, Har, or FF probed in the immu- noblot for AZIN1 and ODC1. (B) Cytoplasmic and nuclear fractions of ...
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The Aryl Hydrocarbon Receptor: A Target for Breast Cancer Therapy
... transcriptional activity has been shown to require calcium changes induced by ligand ...calpain activity. Inhibition of calpain activity with a spe- cific inhibitors blocks transcriptional ...
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Effect of Dialysis on Aryl Hydrocarbon Receptor Transactivating Activity in Patients with Chronic Kidney Disease
... AHRT activity and intracellular ATP content were collected before initiation and after termi- nation of dialysis on weekdays among HD patients and at monthly check ups for PD and CKD stage IV and V ...
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Evaluation of Estrogenic Receptor (ER) and Aryl Hydrocarbon Receptor (AhR) Agonists in Three Gorges Reservoir, China Using SPMD Based Virtual Organisms
... sedimentation effect in the reservoir. Since nearly half of trapped suspended solids in TGR settled in the most industrialized and urbanized areas CS and WZ in the TGR [7], the composition of compounds settled with sus- ...
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Co-expression of the aryl hydrocarbon receptor and estrogen receptor in the developing teeth of rat offspring after rat mothers’ exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the protective action of α-tocopherol and acetylsalicylic acid
... peroxidase activity was blocked with Peroxidase Blocking Reagent (DAKO, Gdynia, ...Estrogen Receptor antibody, rabbit monoclonal antibody (Sigma–Aldrich, Dorset, UK) for 1 h in a dilution of 1:80; then, the ...
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Deletion of the Aryl Hydrocarbon Receptor Enhances the Inflammatory Response to Leishmania major Infection
... ing that the levels of this cytokine are increased when AhR is not functional. The mechanism by which AhR affects TNF- expression is not well understood. However, because TNF- is regulated by NF- B [24], and AhR and ...
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Roles for the Aryl Hydrocarbon Receptor in the Immune Response to Toxoplasma Gondii
... suppressive activity (Chaudhry et ...IL-10 receptor-blocking antibody during chronic infection also exhibit increased mortality, indicating that IL-10 also limits pathological responses chronically ...
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IMMUNOREGULATION OF LIVER REGENERATION BY THE ARYL HYDROCARBON RECEPTOR: ROLE OF LYMPHOCYTES AND INTERFERON-GAMMA
... AhR activity regulates in vivo cell cycle progression, as TCDD treatment may suppress proliferation through direct effects on hepatocytes, as well as by modulating cytokine production by other cells in the ...
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Original Article Expression of aryl hydrocarbon receptor in relation to p53 status and clinicopathological parameters in breast cancer
... AhR activity [24]. Meanwhile, AhR ligand TCDD can counter- act the activity of p53 (phosphorylation and acetylation) triggered by genotoxicants in the human hepatocarcinoma cell line HepG2 ...
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Assessment of pesticides in surface water samples from Swedish agricultural areas by integrated bioanalysis and chemical analysis
... estrogen receptor, and 77% of the samples activated the aryl hydrocarbon ...AhR activity was strongly correlated with oxidative stress in samples with a high AhR ...
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Estrogen receptor beta inhibits transcriptional activity of hypoxia inducible factor 1 through the downregulation of arylhydrocarbon receptor nuclear translocator
... as aryl hydrocarbon receptor nuclear transloca- tor (ARNT) ...ER activity [2]. ARNT is also required for aryl hydrocarbon receptor (AhR) function in ...
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The Aryl Hydrocarbon Receptor Governs Epithelial Cell Invasion during Oropharyngeal Candidiasis
... As a prototypic Th1 cytokine, interferon gamma (IFN- ␥ ) has been used as adjunctive therapy for patients with both hematogenously disseminated candidiasis and multidrug- resistant OPC (23, 24). When administered ...
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Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer
... as aryl hydrocarbon receptor nuclear translocator (ARNT) and binds to aryl hydrocarbon receptor (AhR) to pro- mote its translocation to the nucleus ...for activity and ...
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Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor Mediated Pathway To Promote HIV 1 Infection and Reactivation
... to aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor which is involved in the regulation of a metabolism pathway that senses environmental toxins and endogenous ligands ...
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Role of dendritic cells in the induction of regulatory T cells
... receptor (VDR) [73]. VDR is expressed on immune cells such as DCs and Vitamin D treatment of DC inhibits maturation along with their ability to prime alloreactive T cell response [74]. Keratinocytes in the ...
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<p>Resistance Mechanism of PD-1/PD-L1 Blockade in the Cancer-Immunity Cycle</p>
... However, DCs often do not function ef fi ciently in the tumor environment. The tumor microenvironment can affect the distribution, differentiation, and maturation of DCs. (1) The tumor microenvironment affects DCs distri- ...
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Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway
... pathway suggests that chronic inflammation induced by a prolonged increase of PGE2 could lead to activation of WNT signaling resulting in cell proliferation and cancer. PGE2 enhances the beta-catenin-dependent transcrip- ...
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Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma
... HIF-1 is a basic helix-loop-helix-PAS heterodi- mer composed of an alpha and a beta subunit [19, 22]. The beta subunit, also called aryl hydrocarbon recep- tor nuclear translocator (ARNT), is a ...
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Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions
... tional activity of several members of the NR family including the glucocorticoid (GR/NR3C1), estrogen (ER/ NR3A1&2), vitamin-D3 (VDR3/NR1I1), nuclear receptor subfamily 4, group A, member 2 (NR4A2), ...
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Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis
... AHR: aryl hydrocarbon receptor; AHRR: AHR repressor; B α P: benzo(a)pyrene; Ct: threshold cycle; CYP: cytochrome P450; DMARDs: disease-modifying anti-rheumatic drugs; DMSO: dimethylsulphoxide; GAPDH: ...
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