ASSEMBLY AND MATURATION
Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion
... of assembly, maturation, degradation, and egress of infectious HCV ...HCV assembly and maturation occur in the endoplasmic reticulum (ER) and post-ER compartments, respectively, and that both ...
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Double-stranded RNA Bacteriophage phi6 : Self-assembly and Maturation of the Procapsid
... 4.2.4 The role of P4 in PC assembly and maturation 4.2.4.1 High P4 occupancy is needed for PC formation P4 is a ring-shaped hexamer essential for nucleation in Φ6 PC self-assembly (see 1.3.1.3; ...
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Analysis of the assembly and maturation processes of the Infectious Bursal Disease Virus capsid
... Proteolytic Maturation—(p)VP2 residues Asp- 391 and Asp-431 appeared to be likely candidates to trigger a nucleophilic attack on the pVP2 441– 442 scissile ...efficient assembly of virus-like parti- cles ...
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Identification of a Structural Element in HIV 1 Gag Required for Virus Particle Assembly and Maturation
... DISCUSSION Analysis of CA sequences across HIV-1 subtypes revealed the presence of a highly conserved, Pro-rich motif in a short, exposed loop between helices 6 and 7 in the CA-NTD. In the present study, we determined ...
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Infectious Bursal Disease Virus Capsid Assembly and Maturation by Structural Rearrangements of a Transient Molecular Switch
... effective assembly pathway that avoids the dominance of aberrant assemblies would be provided by a postassembly maturation step in which virions are initially assembled as a procapsid that matures through ...
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Uncovering complex microbiome activities via metatranscriptomics during 24 hours of oral biofilm assembly and maturation
... ing maturation in a mechanism that is not yet under- ...biofilm assembly on a tooth sur- face is initiated by early colonizing bacteria found in saliva, which bind to the newly deposited acquired pellicle ...
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Assembly and Maturation of the Flavivirus Kunjin Virus Appear To Occur in the Rough Endoplasmic Reticulum and along the Secretory Pathway, Respectively
... intracellular assembly site for flaviviruses in currently not known but is presumed to be located within the lumen of the rough endoplasmic reticulum ...the assembly and maturation of ...affect ...
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HIV 1 Assembly, Release and Maturation
... include assembly of structural precursors, budding of the new particle and maturation into fully infectious ...appropriate assembly of structural components, the efficient re- cruitment of viral and ...
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Rescue of Maturation Off-Pathway Products in the Assembly of Pseudomonas Phage ϕ6
... the maturation expansion pathway of 6 PC allows reprogramming of biological ...activity. Assembly of the P4 hexamers on the PC shell results in the stabilization of the compact naive conformation of the PC ...
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Genome Assembly and Particle Maturation of the Birnavirus Infectious Pancreatic Necrosis Virus
... the maturation of particles ...particle maturation, compounds that could have antiprotease activity were assayed as inhibitors: IAA, PMSF, and ...the assembly of particles A in the absence of ...
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The Maturation Process of pVP2 Requires Assembly of Infectious Bursal Disease Virus Capsids
... VLP assembly was further investigated by expression of additional IBDA-derived ...final maturation process converting pVP2 into the VP2 mature form was observed on generated ...
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Amino acid substitutions in the poliovirus maturation cleavage site affect assembly and result in accumulation of provirions.
... DISCUSSION In this study, we have utilized oligonucleotide site-directed mutagenesis to construct two separate mutations in the P1 gene of poliovirus in the region encoding the Asn-Ser site of maturation cleavage ...
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CIP2A acts as a scaffold for CEP192 mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation
... INTRODUCTION Assembly of a bipolar spindle is essential to ensure accurate chromosome segregation and to prevent ...centrosome maturation and separation required for spindle assembly (Berdnik and ...
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Assembly-dependent maturation cleavage in provirions of a small icosahedral insect ribovirus.
... Extracts from nodavirus-infected Drosophila cells contained detergent-labile 140S "young" particles much richer than mature virions in their content of protein alpha, a precursor[r] ...
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A Single Maturation Cleavage Site in Adenovirus Impacts Cell Entry and Capsid Assembly
... particle assembly and ...the assembly assay clearly show an increase in total immature particle yields, even when the primary infection is initiated with the same number of infectious ...
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Assembly of viral membranes: maturation of the vesicular stomatitis virus glycoprotein in the presence of tunicamycin.
... Assem- bly of vesicular stomatitis virus glycoprotein and matrix protein into Hela cell plasma membranes. Transla- tion and identification of the viral mRNA species iso- lated from subce[r] ...
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Three-Dimensional Structures of the A, B, and C Capsids of Rhesus Monkey Rhadinovirus: Insights into Gammaherpesvirus Capsid Assembly, Maturation, and DNA Packaging
... capsid maturation, and indicated that gammaherpesvirus capsids mature in a path- way similar to that of capsids of HSV-1, the prototype of the alphaherpesvirus ...
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Study of herpes simplex virus maturation during a synchronous wave of assembly.
... Nevertheless, all of these events resumed upon downshift to the permissive temperature (data not shown). DISCUSSION A powerful tool in the study of complex biological phenom- ena is the ability to monitor the fate of a ...
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Protease mediated maturation of HIV: Inhibitors of protease and the maturation process
... second-generation maturation inhibitor to over- come the problem of intrinsic drug resistance encountered by ...improved maturation inhibitors has highlighted a need to further our understanding of the ...
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A domain of the hepadnavirus capsid protein is specifically required for DNA maturation and virus assembly.
... This "amplification" of cccDNA is necessary for high levels of virus production (29), but is under strict control of the large viral envelope protein (P36 in the duck hepatitis B[r] ...
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