asthma phenotypes
Clinical profile of predefined asthma phenotypes in a large cohort of UK primary care patients (Clinical Practice Research Datalink)
... on asthma phenotypes in a large general asthma population, we were able to identify patients who fitted three previously suggested phenotypes: benign, early-onset atopic and obese ...
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Different expression levels of interleukin-35 in asthma phenotypes
... in asthma patients or if these dissimilar results can be explained by the heterogeneity of asthma airway inflammation or differences in asthma ...in asthma and may participate in the airway ...
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Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012
... of asthma phenotypes was described ...eosinophilic asthma were examined. The extent of overlap with other phenotypes commonly reported in the literature, among adults with asthma from ...
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Comparison of hypothesis- and data-driven asthma phenotypes in NHANES 2007–2012: the importance of comprehensive data availability
... with asthma from population-based ...of asthma based on clinical markers and ques- tionnaire data commonly available in primary health care or large epidemiological studies and found a larger range of ...
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Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory?
... As previously shown [3, 11], patients with a raised sputum eosinophilic inflammation also had the highest levels of blood eosinophils (absolute values or percent- ages). Moreover, we found that the highest levels of ab- ...
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Determinants of asthma phenotypes in supermarket bakery workers
... different phenotypes of asthma among workers in this emerging and relatively poorly regulated ...industry. Asthma phenotypes were defined on the basis of clinical asthma, airway ...
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Asthma phenotypes: the intriguing selective intervention with Montelukast
... and asthma treatment out- comes [11]; real life studies have limitations, primarily stemming from the lack of randomization (the lack of pa- tient selection, one of the most distinctive characteristics of real ...
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Multivariate Asthma Phenotypes in Adults: The Quebec City Case Control Asthma Cohort
... Objectives: Asthma is a heterogeneous disease where patient severity can be classified according to various models based on numerous ...Case-Control Asthma Cohort and to identify homogeneous subgroups of ...
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Comparison of asthma phenotypes in OVA-induced mice challenged via inhaled and intranasal routes
... human asthma, these can be limited by eth- ical ...human asthma development and progression ...induce asthma in mice, including different mouse strains, aller- gens, and administration routes [10, ...
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The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study
... the asthma phenotype (in terms of total IgE levels) may also vary and numerous studies have been conducted to investigate the relationship between CD14 variants and total IgE levels ...adult asthma ...
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Innate lymphocyte cells in asthma phenotypes
... ILC1s, formerly known as conventional NK cells, are present in mucosal tissues, express the IL-7 receptor, and rapidly secrete IFN-γ upon stimulation with IL-12 and IL-18, which are produced by macrophages and other ...
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Asthma Phenotypes, Risk Factors, and Measures of Severity in a National Sample of US Children
... nonatopic asthma, 3.4% as having resolved asthma, and ...no asthma diagno- ...4 asthma phenotypes. Children with nonatopic asthma had higher mean ...resolved asthma ...
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Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study
... of asthma, as opposed to demographic and historical aspects of the ...atopy, asthma age-of-onset, BMI, ICS dose; 20 variables total), resulted in weaker clustering (based on distance metrics and clus- ter ...
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Effects of Nerve Growth Factor shRNA Inhibition on Asthma Phenotypes in a Mouse Model of Asthma
... Similar with our results, Chen and co-workers reported that knockdown of NGF with siRNA significantly reduced airway resistance, NGF levels, proinflammatory cytokines, and eosinophil infiltration into airways in a mouse ...
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Original Article Boswellic acid attenuates asthma phenotypes by downregulation of GATA3 via pSTAT6 inhibition in a murine model of asthma
... In the present study, no significant difference was found in baseline airway resistance among the six groups. The airway resistance generat- ed by administration of Mch at doses from 30 to 270 μg/kg increased ...
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To Study the Epidemiological Aspects in Determining the Prevalence and Expression of Asthma Phenotypes in the Urban Population of North Chennai
... study detected a higher asthma prevalence in larger families while some had found no association between two. Broad implications of the protective mechanism of the sibling were explained in various theories. One ...
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Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes
... A subset of 592 Newborn Epigenetic Study (NEST) subjects was also evaluated for the association between PTS exposure and AXL methylation. NEST is a pro- spective study of women and their children [23]. It was designed to ...
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Small airway dysfunction and bronchial asthma control : the state of the art
... of asthma phenotypes and associ- ated comorbidities are the main contributing factors to poor disease control [20–24], but there is now a consid- erable amount of evidence supporting the concept that a ...
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The puzzle of immune phenotypes of childhood asthma
... clinical asthma manifestation in school children has previously been classified as allergic and non-allergic ...childhood asthma. Whereas traditional classification of childhood asthma is primarily ...
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Severe bronchial asthma in children: a review of novel biomarkers used as predictors of the disease
... Severe asthma or therapy-resistant asthma in children is a heterogeneous disease that affects all ...patient phenotypes and endotypes using the appropriate biomarkers, it will assist in providing the ...
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