Atherosclerotic lesion
The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis
... to lesion formation was ...in atherosclerotic lesion size and total serum cholesterol is observed with a switch at 1000 mg/dL serum cholesterol from an atheroprotective function of ABCG1 to a ...
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Activated transcription factor nuclear factor kappa B is present in the atherosclerotic lesion
... involved (45, 46). In this environment, it is suggested that mac- rophages express a variety of genes, e.g., cytokines (4, 8–10), TF (20–23), or ICAM-1 (27, 42), that are regulated by the NF- kB system in a fashion ...
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Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
... quantified lesion development. There was a 76.5% decrease in aortic tree lesion area (Western diet) and a 45% decrease in aortic sinus lesion area (normal chow) in the CD36-apo E double-null mice ...
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Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE deficient mice
... weeks), atherosclerotic lesion formation was observed in the aortic sinus of apoE-KO mice (Figure ...the lesion size was significantly increased ...the atherosclerotic plaque areas were ...
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p47phox is required for atherosclerotic lesion progression in ApoE–/– mice
... combine with nitric oxide to form peroxynitrite, a potent oxidizing species, which can also oxidize LDL. We report here that expression of a component of NADPH oxidase, p47phox, is necessary for SMC response to growth ...
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Gene Expression in Atherosclerotic Lesion of ApoE Deficient Mice
... human atherosclerotic lesions and confirmed in a related mouse model, the LDL receptor-deficient mouse ...in atherosclerotic ApoE-/- mice at 10 weeks (Table ...and atherosclerotic human vascular ...
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Role of the Immunological System in the Initiation and Progression of Atherosclerosis
... the atherosclerotic lesion, which contains macrophages, dendritic cells and non-classical antigen presenting cells such as smooth muscle cells and endothelial cells that all can express MHC class II ...
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Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model
... increased atherosclerotic lesion area and complexity, and enhanced expression of receptor for advanced glycation end products (RAGE), VCAM-1, tissue factor, and MMP-9 in the ...in atherosclerotic ...
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Transcatheter treatment of atherosclerotic lesions of the brain complicated by vascular dementia development
... arteries lesion, after which the laser treatment is carried ...the atherosclerotic lesion, the type of the laser system used, and takes from 30 seconds to 40 min- ...
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Macrophage lipid genes in cardiovascular disease
... injection into the tail vein. The recipient mice were housed in sterilized filter-top cages and given unlimited access to food and water. They were maintained for 8 weeks on a sterilized regular chow, containing 4.3% ...
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Enhanced atherosclerosis and kidney dysfunction in eNOS–/–Apoe–/– mice are ameliorated by enalapril treatment
... Hypertension and atherosclerosis are major factors in the etiology of ischemic heart disease and cerebrovas- cular disease — the 2 leading causes of death worldwide — and are important in the development of kidney dys- ...
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The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model.
... previously noted protection in this model with simvastatin, due to its immunomodulatory properties, correlating with a shift from a Th1 (pro-inflammatory) to a Th2 (anti-inflammatory) immunological phenotype (Aprahamian ...
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Dyslipidemia, metabolism and autophagy : antigen-independent modulation of T cells in atherosclerosis
... A hallmark of advanced atherosclerosis is inadequate immunosuppression by regula- tory T (Treg) cells inside the atherosclerotic lesion. Here we show that this impairment is not due to a reduction in ...
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AT1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated via PPARγ
... of atherosclerotic lesions was quantified in diabetic and non-diabetic animals using oil red O- staining and macroscopic analysis of the aortic root after 18 ...-mice, atherosclerotic lesions were ...
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Current knowledge on the mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols
... an atherosclerotic lesion is shown in a study on apoE-knockout mice, in which the applied endothelial-targeted inhibition of NF- κB signalling results in a decrease in the lesion area, which was ...
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Macrophage mediated 15 lipoxygenase expression protects against atherosclerosis development
... aortic atherosclerotic lesions (18); and (d) the mouse, another popular animal model of atherosclerosis, has 12-LO but no 15-LO and is thus not as suitable a model for ...in atherosclerotic lesion ...
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Moderate beer consumption does not change early or mature atherosclerosis in mice
... Control C57BL/6 mice and genetically-modified mice such as apolipoprotein (apo) E-deficient mice (apoE-/- mice) are now widely used to examine the impact of die- tary factors on early and mature atherosclerosis [5,6]. ...
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Prediction of Coronary Atherosclerotic Ostial Lesion with a Damping of the Pressure Tracing during Diagnostic Coronary Angiography
... non-ostial atherosclerotic le- sions emerged as an important predictor for coronary athero- sclerotic ostial ...true lesion group showed more numbers of diseased vessels and much se- vere diameter stenosis, ...
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Current Concepts of Vascular Injury and Thrombosis in the Pathogenesis of Coronary Atherosclerosis
... of atherosclerotic plaque which is now a reality (as observed in multiple experimental and angiographic human studies) should include, retardation of the key events in lesion initiation; enhance plaque ...
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Will absence of GPAT1 improve diet-induced atherosclerosis in ApoE heterozygous mice?
... NEM-resistant GPAT1 activity in ob/ob mice decreased liver TAG and DAG content 40-50% and decreased plasma glucose level and plasma cholesterol level content 30-40% (67). The increasing of FA oxidation in the mtGPAT1 ...
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