atherosclerotic lesions
Localization of distinct F2 isoprostanes in human atherosclerotic lesions
... Healthy tissue is not removed during endarterectomy, so comparison of diseased tissue with apparently uninvolved carotid vasculature ob- tained at endarterectomy is not possible. Vascular tissue, apparently devoid of ...
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Increased ferritin gene expression in atherosclerotic lesions
... lated and identified to be genes encoding L-ferritin and H-ferritin, respectively. Northern blot analysis confirmed that the expression of both ferritin genes was notably higher in human and rabbit atherosclerotic ...
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Presence of hypochlorite modified proteins in human atherosclerotic lesions
... human atherosclerotic lesions contain active MPO (16), homogenates were also prepared using an azide- and methionine-containing buffer, to inhibit this en- zyme and scavenge any HOCl potentially produced ...
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Globular domain of adiponectin: promising target molecule for detection of atherosclerotic lesions
... performed independent of gender. Injured endothelium was defined as the activated endothelial layer covering the atherosclerotic lesions of apoprotein E-deficient mice. For each ex vivo staining trial, ...
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CCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions
... Since TNF α and IFN γ are the most important proin- flammatory cytokines mainly expressed by macrophages in atherosclerotic lesions, we focused on these two cytokines and analyzed the effect of CCL19 and ...
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Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions
... myeloperoxidase detected a 56-kD protein, the predicted molecular mass of the heavy subunit. Both the immunoreactive protein and authentic myeloperoxidase bound to a lectin- affinity column; after elution with methyl ...
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Transcatheter treatment of atherosclerotic lesions of the brain complicated by vascular dementia development
... of atherosclerotic lesions accompanied by vas- cular dementia ...of atherosclerotic lesions of cerebral vessels were examined during the ...sclerotic lesions of the brain accompanied by ...
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Reduction of atherosclerotic lesions in rabbits treated with etoposide associated with cholesterol-rich nanoemulsions
... rabbit atherosclerotic lesions by strongly diminishing the proliferation in the intima of VSMC and macrophages, decreasing the production of pro-inflammatory factors such as IL-1 β , TNF- α , and ...of ...
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New mechanism for foam cell generation in atherosclerotic lesions
... Because of a close association between platelets and macrophages in early fatty streak lesions, the hypothesis was tested that platelets contribute to lesion progression by directly enhancing macrophage ...
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Decreased type II/type I TGF beta receptor ratio in cells derived from human atherosclerotic lesions Conversion from an antiproliferative to profibrotic response to TGF beta1
... vascular lesions are growth stimulated by TGF- beta1 and markedly increase collagen ...vascular lesions, receptor-variant cells would be allowed to grow in a slow, but uncontrolled fashion, while ...
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The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation
... iments using aorta from hypercholesterolemic Watan- abe rabbits demonstrated that CD43, leukosialin, may also mediate macrophage adhesion (36). A role for other adhesion molecules in atherosclerosis has also been ...
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Residual Stresses Computing in Blood Vessels in virtue of Pathological Growth Processes
... O RGANS in the human body and animals morphologi- cally discriminate in two types: tubular and stromal. The first ones are a cavity with walls such as vessels, bronchial tubes, bile ducts, gastrointestinal tract, etc. ...
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Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
... acid–treated atherosclerotic mice (mean ± SEM; n = 5 ...atherosclerotic lesions. Shown is the number of macrophages homing into lesions of the ...
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Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE deficient mice
... Inducible NOS (iNOS) is also shown to be involved in atherogenesis (21, 44, 45). In immunohistochem- istry, we detected iNOS expression mainly in the foam cell–rich regions of atherosclerotic lesions in ...
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Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice
... atherosclerotic lesions and this role could be blocked by C5aR antagonist. To confirm these findings, we performed in vitro migration assay and found prominent macrophage chemotaxis of recombinant mouse C5a ...
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Per os colchicine administration in cholesterol fed rabbits: Triglycerides lowering effects without affecting atherosclerosis progress
... Animals were allowed 2 weeks of acclimatization after arrival and then were randomly separated in three ex- perimental groups. Animals in the Control group (n = 6) were fed standard commercial rabbit diet (ND), animals ...
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Dual Antiplatelet Therapy Monitoring for Neurointerventional Procedures Using a Point of Care Platelet Function Test: A Single Center Experience
... Our study had several limitations, including its retrospec- tive design and the heterogeneity of the patient group, which included patients with intracranial aneurysms and those with atherosclerotic ...
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Mathematical and numerical modeling of early atherosclerotic lesions*,**
... Abstract. This article is devoted to the construction of a mathematical model describing the early formation of atherosclerotic lesions. The early stage of atherosclerosis is an inflammatory process that ...
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Original Article Effects of Smad decoy ODN on shear stress-induced atherosclerotic ApoE-/-mouse
... Shear stress controls the expression of a num- ber of genes involved in the endothelial cell functions, including TGF-β1, platelet–derived growth factor (PDGF), and tissue plasminogen activator. In particular, TGF-β1 is ...
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Myricetin and Hesperidin Inhibit Cerebral Thrombogenesis and Atherogenesis in Apoe / and Ldlr / Mice
... Arteriosclerosis was assessed by estimating the development of atherosclerotic lesions as a percent of the entire surface area of the aorta [29] [30]. Briefly, hearts were exposed by abdominal incision and ...
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