Atovaquone/proguanil
Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone proguanil
... apparently atovaquone-sensitive parasites is consistent with the find- ings of Musset et al [5], who demonstrated low plasma levels of atovaquone, proguanil and cycloguanil (an active metabolite of ...
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Detection of atovaquone proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola
... on atovaquone-proguanil treatment failure associated mutations ever done in this ...extensive atovaquone-proguanil introduction in the market, future studies will be important to monitor these ...
5
In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand
... of atovaquone and proguanil (Malarone) has been proved to be effective for the treatment and prophylaxis of malaria which is already approved by countries in North America and ...to ...
5
The diminishing returns of atovaquone proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment
... The modelling suggests that use of A-P for MDA is questionable, despite the advantage of avoiding additio- nal artemisinin drug pressure. The modelling predicts that the contribution to spread of artemisinin resistance ...
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Confirmation of emergence of mutations associated with atovaquone proguanil resistance in unexposed Plasmodium falciparum isolates from Africa
... It has been suggested that AP resistant phenotypes might arise through strong selection of resistant sub-populations harboring resistance associated mutations [12,29] or, through a mutagenic capacity of atovaquone ...
7
Atovaquone proguanil in the treatment of imported uncomplicated Plasmodium falciparum malaria: a prospective observational study of 553 cases
... A pre-travel consultation was reported in 267 travel- lers (48.3%), mostly by their family practitioner (42.3%). Two-hundred and twenty-two patients (40.1%) declared having taken malaria chemoprophylaxis (chloroquine- ...
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Pharmacometabolomic study of the human malaria parasite, Plasmodium falciparum: new insights into parasite biology and mode of drug action
... with atovaquone, atovaquone-proguanil, CK-2- 68, 5-fluoroorotic acid, potassium cyanide and bongkrekic acid; and those treated with thenoyltrifluoroacetone, proguanil, and fusidic acid as well ...
408
Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn based interactivity calculations
... by dose-dependent toxicity (emesis and cardiotoxicity). Identification of a synergistic partner drug would present an opportunity for dose-reduction, thus increasing the therapeutic win- dow. The lack of reliable and ...
21
Antimalarial pharmacology and therapeutics of atovaquone
... when atovaquone was pre-incubated with human serum and centrifuge-filtered to remove protein before use, no CYP2C9 inhibitory activity was ...although atovaquone has the capacity to inhibit CYP3A4 and ...
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Rapid identification of chloroquine and atovaquone drug resistance in Plasmodium falciparum using high resolution melt polymerase chain reaction
... of atovaquone resistance in ...of atovaquone to the cytochrome ...with atovaquone/proguanil treatment failure in vivo and can be used as possible resistance ...
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Improving Pediatric Dosing Through Pediatric Initiatives: What We Have Learned
... of atovaquone after admin- istration of atovaquone/proguanil is shorter in pedi- atric patients (1–2 days), compared with adults (2–3 ...of proguanil is 12 to 21 hours in pediatric and adult ...
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Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial
... line: Atovaquone/proguanil, dotted line: Artemether/ ...the Atovaquone/proguanil and Artemether/lumefantrine group unlike the Quinine group, which experienced a marked but tran- sient hearing ...
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New liquid chromatographic method for simultaneous quantification of Atovaquone and Proguanil with its active metabolite Cycloguanil in human plasma
... of atovaquone and proguanil with its active metabolite cycloguanilin human ...Moreover, atovaquone, proguanil and cycloguanilwere stable in plasma at various stability ...
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Intervals to Plasmodium falciparum recurrence after anti malarial treatment in pregnancy: a longitudinal prospective cohort
... Results: From December 1994 to November 2009, 700 women were treated for P. falciparum and there were 909 recurrent episodes (481 novel and 428 recrudescent) confirmed by PCR genotyping. Most of the recurrences, 85 % ...
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Babesiosis in Long Island: review of 62 cases focusing on treatment with azithromycin and atovaquone
... and atovaquone), however not simultaneously (Table ...azithromycin atovaquone to quinine/clindamycin (patients 2 and 3 in Table 3), the decision was made based on percent parasitemia on admission, but not ...
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Novel Synergistic Protective Efficacy of Atovaquone and Diclazuril on Fetal Maternal Toxoplasmosis
... of atovaquone and diclazuril against fetal-maternal toxoplasmosis, animals were divided into groups of 18 - 24 ...regimens, atovaquone monotherapy, diclazuril mo- notherapy, atovaquone + diclazuril ...
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Designing the next generation of medicines for malaria control and eradication
... Abbreviations ACPR: Adequate clinical and parasitological response; ACT: Artemisinincombination therapy; API: Active Pharmaceutical Ingredient; ATQ: Atovaquone; CMR: Centre for Medicines[r] ...
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Efficacy, safety and tolerance of imidocarb dipropionate versus atovaquone or buparvaquone plus azithromycin used to treat sick dogs naturally infected with the Babesia microti like piroplasm
... To date, however, no drug has proved capable of clearing Bml infection in dogs. Imidocarb dipropionate remains the first choice treatment against large Babesia species infection, but when used to treat small species ...
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In vitro and in vivo combination of cepharanthine with anti malarial drugs
... Abbreviations ACT: Artemisinin combination therapy; ANOVA: Analysis of variance; AQ: Amodiaquine; ATO: Atovaquone; CEP: Cepharanthine; CQ: Chloroquine; DHA: Dihydroartemisinin; ECM: Expe[r] ...
6
Management of <em>Pneumocystis Jirovecii</em> pneumonia in HIV infected patients: current options, challenges and future directions
... Atovaquone is hydroxy-1,4-naphthoquinone, an analog of ubiquinone, that was initially developed as an antimalarial agent. It also has activity against P. jirovecii but is less effective than the above regimens.The ...
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