atp-binding
Identification of mutations in the putative ATP binding domain of the adrenoleukodystrophy gene
... peroxisomal protein of 745 amino acids that includes one domain for ATP-binding, termed nucleotide-binding fold (NBF). To determine whether mutations occur in the putative NBF of ALD protein, we ...
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The impact of ATP-binding cassette transporters on metabolic diseases
... metabolism. ATP binding cassette (ABC) transporters are one of the largest transport protein superfamilies that exist in nearly all living organisms and are mainly located on lipid-processing ...
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A Review on ATP Binding Cassette (ABC) Transporters
... The ATP binding cassette (ABC) proteins represent a highly diversify superfamily in all living kingdoms, with 50 human proteins, 14 of which are associated with various ...
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Combining Mutations That Inhibit Two Distinct Steps of the ATP Hydrolysis Cycle Restores Wild Type Function in the Lipopolysaccharide Transporter and Shows that ATP Binding Triggers Transport
... for ATP hydrolysis, with E163 being the catalytic glutamate in wild-type LptB (15, ...for ATP binding and/or hydrolysis and its coupling for the function of the ...
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ATPsite: sequence-based prediction of ATP-binding residues
... Background: ATP is a ubiquitous nucleotide that provides energy for cellular activities, catalyzes chemical reactions, and is involved in cellular ...the ATP-protein interactions helps with annotation of ...
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ABC transporter ATP-binding
... Supplementary Table 1: Blast hits of genes which have been horizontal transferred. The first hit a in all the cases is Methylotetracoccus oryzae C50C1 (Mtt C50C1) (except 35) whereas the second hit is from a different ...
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Theoretical Study on the ATP Hydrolysis Mechanism of HisP Protein, the ATP Binding Subunit of ABC Transporter
... of ATP in the binding site of HisP protein, the ATP binding site was truncated from energetic minimized crystallized structure, including ATP molecule, conserved residues (Gln100, ...
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Human ATP-binding cassette (ABC) transporter family
... the ATP-binding cassette (ABC) ...by ATP hydrolysis to move substrates across membranes in or out of cells or into cellular vesicles, against their electrochemical ...
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Effect of ATP Binding and Hydrolysis on Dynamics of Canine Parvovirus NS1
... an ATP-dependent process (42). Although there is no direct link between ATP binding and the multimerization of auton- omous parvovirus NS1 proteins, some indirect evidence exists ...on ATP in ...
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Novel analytical methods to interpret large sequencing data from small sample sizes
... in ATP-binding cassette subfamily B member 1 (ABCB1 also known as multidrug resistance protein 1, MDR1), encoding a major IM membrane efflux trans- porter, have already been identified and associated with ...
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Roles of sphingosine-1-phosphate signaling in cancer
... ABCC1: ATP- binding cassette C1; ABCG2: ATP-binding cassette G2; Spns2: spinster 2; S1PRs: S1P receptors; Gq, Gi, and G12/13: G protein α subtypes; AKT: protein kinase B; ERK1/2: extracellular ...
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The Anopheles gambiae ABC transporter family: phylogenetic analysis and tissue localisation provide clues on function and role in insecticide resistance
... ABC transporters contain conserved cytosolic ATP binding domains (nuclear binding domains) and more variable transmembrane domains (TMDs) that determine the substrate specificity. Half transporters ...
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Characterization and Protective Property of Brucella abortus cydC and looP Mutants
... the ATP/GDP-binding protein motif A (P-loop) (named looP; des- ignated here the IVKB9007 looP::Tn5 mutant) and the ATP-binding/permease protein (cydC; designated here the IVKB9007 cydC::Tn5 ...
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"We Are Not Hired Help:" The 1968 Statewide Florida Teacher Strike, the Rise of Modern Conservatism, and the Potency of Teacher Power
... Multidrug resistance (MDR) is found in both cancer and bacterial cells. It results from development of resistance against multiple structurally unrelated drugs, which leads to treatment failure. Currently, MDR threatens ...
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Studies on the human choroid plexus in vitro
... The most accessible human CP samples were those that were either taken from aborted embryos or from post-mortem adult brains. Human embryonic CP samples have been used to analyze the expression of transport proteins that ...
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WNT signaling – lung cancer is no exception
... ABC: ATP-binding cassette; ABCB1: ATP-binding cassette transporter protein B1; ABCG2: ATP-binding cassette transporter protein G2; AC: adenocarcinoma; AE: alveolar epithelium; ...
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Alkylation of staurosporine to derive a kinase probe for fluorescence applications
... Kinases that were inhibited by compound 8 to a similar extent as PKA include RSK1, PDK1, ROCK 2, PKCa, MSK1, GSK3b, Aurora B, AMPK (hum), MARK3, TBK1, PAK4, MST2, MLK3, IRAK4, Src, Lck, BTK, JAK2, TrkA, and VEG-FR. ...
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Comparative genomics of Butyrivibrio and Pseudobutyrivibrio from the rumen : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Microbiology and Genetics at Massey University, Palmerston North, New Zealand
... hypothetical protein nickel/peptide ABC transporter ATP-binding protein hypothetical protein serine protease flagellar hookassociated protein ABC transporter ATP-binding protein RelA/Spo[r] ...
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Dubin–Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report
... the ATP-binding cassette sub-family C member 2 gene ABCC2 that encodes the Multidrug resistance-associated protein 2 that causes Dubin–Johnson ...the ATP-binding cassette, sub-family B member ...
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Molecular chess? Hallmarks of anti cancer drug resistance
... (2)Expression of drug efflux pumps: The ATP-binding cassette (ABC) superfamily of proteins includes a number of membrane proteins able to transport a wide diversity of substrates. Besides an ability to ...
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