ATP-binding cassette transporter A
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors
... the ATP-binding cassette transporter A- 1 (ABCA1), ABCA7, apolipoprotein C2 (APOC2), APOC4, and phospholipid transfer protein (PLTP); the complement pathway VTN gene; and the angiogenesis- ...
20
WNT signaling – lung cancer is no exception
... ABC: ATP-binding cassette; ABCB1: ATP-binding cassette transporter protein B1; ABCG2: ATP-binding cassette transporter protein G2; AC: ...
16
Contributions of Aspergillus fumigatus ATP-Binding Cassette Transporter Proteins to Drug Resistance and Virulence
... selection cassette was released from the plasmid pSKB57 (provided by Stacey Klutts, University of Iowa) by SpeI/EcoRV cleavage and gel puri- ...disruption cassette, while pSP45 was di- gested with AleI/KpnI ...
10
Modulation of Leishmania ABC Protein Gene Expression through Life Stages and among Drug-Resistant Parasites
... ATP-binding cassette (ABC) proteins form the largest fam- ily of transmembrane proteins and are found in all living or- ganisms ...the ATP- dependent transport of a variety of molecules across ...
13
Quantification of CDR1 Gene Expression in Fluconazole Resistant Candida Glabrata Strains Using Real-time PCR
... of ATP-binding cassette (ABC) transporter family membrane proteins such as; Cg CDR1, Cg CDR2 are responsible for fluconazole resistance in a large proportion of candidiasis ...
5
Dubin–Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report
... Prevalence of ICP is around 1% in Northern Europe, and is more common in Scandinavian and Chilean ances- try [11]. It is rare in Asia, but this may be because of low case detection rate. ABCB11 gene encodes ...
5
ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches
... the ATP-binding cassette G2 (ABCG2) transporter with serum urate concentration in a genome-wide association study, it was revealed that ABCG2 is an important uric acid ...
14
An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein
... couple ATP hydrolysis to solute trans- location (Holland et ...the transporter, capturing extracytoplasmic substrates and delivering them to the membrane compo- nents for transport (Hosie et ...ABC ...
14
Atovaquone and quinine anti malarials inhibit ATP binding cassette transporter activity
... buffer. Transport was allowed by transfer of the plates to 37°C during 1–5 min, a time-point within the linear phase of time-dependent transport, as previously determined [15-19]. Hereafter, the reaction was rapidly ...
8
Copy number variations of the ATP binding cassette transporter ABCC6 gene and its pseudogenes
... μL Binding Buffer (Qiagen), 2 μL streptavidin sepharose high-performance beads (GE Healthcare, Little Chalfont, United Kingdom) and 18 μL water and stirred for 5– 10 min at 1400 rpm on a ...
6
RPE phagocytic function declines in age related macular degeneration and is rescued by human umbilical tissue derived cells
... [98]. ATP-binding cassette transporter ABCA1 is a protein which in humans is encoded by the ABCA1 ...This transporter is a major regulator of cellular cholesterol and phospholipid ...
15
Molecular chess? Hallmarks of anti cancer drug resistance
... The ATP-binding cassette (ABC) superfamily of proteins includes a number of membrane proteins able to transport a wide diversity of ...ABC transporter molecules [10], many of which can pump ...
8
The role of ATP-binding cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance
... ABC transporter genes in patients with AML in 25, 50 and 75 age levelsdivided into two groups with good and poor response to ...ABCA2 transporter, where the enhanced activity of one protein may compensate ...
9
Insulin-degrading enzyme is exported via an unconventional protein secretion pathway
... the ATP-binding cassette (ABC) transporter inhibitor gly- buride, which is known to stimulate insulin secretion from pancreatic beta cells; Bz-ATP, a known stimulator of P2X7 receptors, ...
5
The Anopheles gambiae ABC transporter family: phylogenetic analysis and tissue localisation provide clues on function and role in insecticide resistance
... The role of ATP-binding cassette (ABC) transporters in conferring insecticide resistance has received much attention recently. Here we identify ABC trans- porters differentially expressed in ...
13
ABC transporter research: going strong 40 years on
... The ATP-binding cassette (ABC) transporter field emerged from studies on nutrient uptake in bacteria in the 1970’s with the biochemical characterization of substrate-binding protein ...
9
Human ATP-binding cassette (ABC) transporter family
... the ATP-binding cassette (ABC) ...by ATP hydrolysis to move substrates across membranes in or out of cells or into cellular vesicles, against their electrochemical ...
10
The COMATOSE ATP-binding cassette transporter is required for full fertility in arabidopsis
... ABC transporter required not only for β- oxidation of storage lipid during germination and establishment but also for biosynthesis of jasmonic acid (JA) and conversion of indole butyric acid (IBA) to indole acetic ...
39
The COMATOSE ATP-binding cassette transporter is required for full fertility in Arabidopsis
... We have shown recently that CTS also contributes to the synthesis of jasmonic acid (JA; Theodoulou et al., 2005). JA synthesis begins in the chloroplast, where membrane-derived linolenic acid (18:3) is converted to ...
15
Metformin in patients with and without diabetes: a paradigm shift in cardiovascular disease management
... Atherosclerotic plaques mainly consist of lipid-rich foam cells deposited under the intima. Mononuclear mac- rophages migrate to the intima, phagocytose choles- terol-containing lipids through cell membrane surface ...
9