ATP-sensitive
Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia
... nitric oxide (NO) modulate HPV during lung inflamma- tion [4]. Voltage gated potassium channels have been shown to be one of the key regulators of HPV [5], but in candidates like Kv1.5, Kv2.1 or Kv3.1, no alteration in ...
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The effect of ATP sensitive potassium channel modulation on heart rate in isolated muskrat and guinea pig hearts
... Other possible candidates for hypoxia-induced bradycardia in the isolated heart are hydrogen ions, lactate and potassium ions. These substances increase in concentration during hypoxia and produce a decrease in heart ...
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Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats
... KATP: ATP-sensitive potassium channels; HR: heart rate; STZ: streptozotoxin; CO: cardiac output; i.p.: intraperitoneal; HG: high glucose; PBS: phosphate- buffered saline; BSA: bovine serum albumin; RIPA: ...
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The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes
... (K ATP ) channel ...K ATP channel activity couples glucose metabolism to insulin secretion via cellular excitability and mutations in either KCNJ11 or ABCC8 genes alter K ATP channel activity, ...
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Lactate activates ATP sensitive potassium channels in guinea pig ventricular myocytes
... of ATP at which activation of the channels occurs and the much higher levels of ATP maintained during myocardial ...on ATP-sensitive potassium channels in adult guinea pig ventricular myocytes ...
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Regulation of the mitochondrial ATP-sensitive potassium channel in rat uterus cells by ROS
... mitoK ATP , depolarized mitochondrial membrane either under oxidative stress or under normal conditions, while mitoK ATP blocker glyben- clamide effectively restored mitochondrial poten- tial in rat ...
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Kir6.2-containing ATP-sensitive K+ channel is required for cardioprotection of resveratrol in mice
... It is well known that the most prominent role of K- ATP channels in cardiovascular system is that opening of this channel can protect cardiac myocytes against is- chemic injuries. K-ATP channels are present ...
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Curcumin inhibits proliferation of gastric cancer cells by impairing ATP sensitive potassium channel opening
... Modern medical studies found that this bioactive agent, extracted from the rhizome of a herb named Curcuma Longa Linn, exerted potent anti-cancer activity by inhi- biting cell proliferation in vitro and in vivo [31]. The ...
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Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction
... Studies have showed that cardiocyte apoptosis played a mechanistic role in endotoxic myocardial depression [23,24], left ventricular myocyte apoptosis was directly in- volved in endotoxe[r] ...
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ATP-sensitive K(+)-channels in muscle cells: features and physiological role
... Але, на відміну від кардіоміоцитів, в яких цей канал активується у відповідь на зменшення концентрації АТР, у гМ судин спонтанна активація K АТР -каналів не відбувається [r] ...
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ATP sensitive potassium channels mediate contraction induced attenuation of sympathetic vasoconstriction in rat skeletal muscle
... In our experiments, glibenclamide also attenuated active hyperemia, which is consistent with previous studies in the ca- nine diaphragm (35, 36) and hamster cremaster muscle (37). We therefore considered the possibility ...
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The ATP sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog
... sulfonylurea glyburide, a specific inhibitor for the K+ATP channel, caused vasoconstriction and restoration of blood pressure. Glyburide also induced vasoconstriction and restoration of blood pressure in the ...
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An investigation of the biochemical interaction between subunits of the ATP-sensitive potassium channel
... presence of proline in a stretch of amino acids can also be an indicator of a region that may act as a good epitope due to its disruption of the folding of a protein. A more specific consideration relates to the ...
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Functional cell biology and molecular pharmacology of ATP sensitive potassium channels
... If the sensitivity of the vasorelaxant responses of pinacidil, KB-R6844 and KB- R6907 to the L-arginine and L-ornithine analogues were entirely due to endothelial NO production, then in the absence of a functional ...
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Expression of ATP-sensitive potassium channels in human pregnant myometrium
... myometrium. Paired US and LS biopsies were obtained from pregnant women at term. The expression level of Kir6.1, Kir6.2, SUR1 and SUR2B were determined by Western blotting as described in Materials and Methods. The ...
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Intracellular ATP can regulate afferent arteriolar tone via ATP sensitive K+ channels in the rabbit
... mM ATP and in a dose-dependent fashion by glibenclamide (10(-9) M to 10(-6) M), a specific antagonist of KATP ...of ATP, and this effect was also blocked by ...intracellular ATP levels can effect AA ...
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Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators
... A role for caicineurin in modulation of ion channel activity has largely come through the use of the caicineurin inhibitors, cyclosporin A and FK-506., Both Na^, Ca^* and K* channels, as well as the NaVK^ ATPase have ...
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The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection
... clathrin coats and promote lysosomal degradation of cytosolic proteins. In addition to the cytosolic forms of HSP70 (constitutive HSP73 and inducible HSP72) a mitochondrial matrix-localised isoform (mt-HSP70) exists ...
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Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle Implications for ischemia and reperfusion injury
... activated ATP-sensitive K+ channels, decreased the calcium current, and caused cell shortening by irreversibly inhibiting glycolytic and oxidative ...
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Conversion of amylase secreting rat pancreatic AR42J cells to neuronlike cells by activin A
... recording of the membrane patch revealed the existence of ATP-sensitive potassium channel in activin-treated cells. These results indicate that activin A converts amylase- secreting AR42J cells to ...
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