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ATP-sensitive potassium channels

Lactate activates ATP sensitive potassium channels in guinea pig ventricular myocytes

Lactate activates ATP sensitive potassium channels in guinea pig ventricular myocytes

... of ATP at which activation of the channels occurs and the much higher levels of ATP maintained during myocardial ...on ATP-sensitive potassium channels in adult guinea pig ...

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ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice

ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice

... calcium channels (Ca2+ channels) and ATP-sensitive potassium channels (K+ channels) in hyperalgesia induced by morphine in dia- betic ...

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The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection

The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection

... increased ATP^, for which ATP hydrolysis is not required but on the other hand ATP hydrolysis is necessary to maintain the channel in an operative state ...of ATP^, PKC upregulates the K^^p ...

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Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

... Involvement of the ATP-dependent potassium channel Kir6.1 in systemic circulation has been demonstrated in numerous studies. Kir6.1 expression is up-regulated in rats in LPS as well as in cecal ligation ...

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Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators

Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators

... 1997), channels are a likely target for mediating at least some of the effects of ...BKca channels can be activated by NO either directly, via nitrosylation of channel proteins ...K atp (Murphy and ...

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Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction

Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction

... channels may offer protection against apoptosis in endotoxemia [10]. Thus, the first aim of this work was designed to assess the role of Kir6.2 subunits on cardiac function and cardiac damage under LPS ...

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Functional cell biology and molecular pharmacology of ATP sensitive potassium channels

Functional cell biology and molecular pharmacology of ATP sensitive potassium channels

... If the sensitivity of the vasorelaxant responses of pinacidil, KB-R6844 and KB- R6907 to the L-arginine and L-ornithine analogues were entirely due to endothelial NO production, then in the absence of a functional ...

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Expression of ATP-sensitive potassium channels in human pregnant myometrium

Expression of ATP-sensitive potassium channels in human pregnant myometrium

... myometrium. Paired US and LS biopsies were obtained from pregnant women at term. The expression level of Kir6.1, Kir6.2, SUR1 and SUR2B were determined by Western blotting as described in Materials and Methods. The ...

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ATP sensitive potassium channels mediate contraction induced attenuation of sympathetic vasoconstriction in rat skeletal muscle

ATP sensitive potassium channels mediate contraction induced attenuation of sympathetic vasoconstriction in rat skeletal muscle

... In our experiments, glibenclamide also attenuated active hyperemia, which is consistent with previous studies in the ca- nine diaphragm (35, 36) and hamster cremaster muscle (37). We therefore considered the possibility ...

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Glucose modulates rat substantia nigra GABA release in vivo via ATP sensitive potassium channels

Glucose modulates rat substantia nigra GABA release in vivo via ATP sensitive potassium channels

... on ATP-sensitive potassium (KATP) ...of ATP by perfusion of 2-deoxyglucose with oligomycin inhibited GABA release by 44 +/- 8 and 45 +/- 11%, ...KATP channels and that inhibition of ...

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Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats

Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats

... KATP: ATP-sensitive potassium channels; HR: heart rate; STZ: streptozotoxin; CO: cardiac output; ...inward-rectifier potassium ion channels ...

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The effect of ATP sensitive potassium channel modulation on heart rate in isolated muskrat and guinea pig hearts

The effect of ATP sensitive potassium channel modulation on heart rate in isolated muskrat and guinea pig hearts

... extracellular potassium concentration during metabolic stress are thought to be mediated primarily by the ATP-sensitive potassium ...Anion-coupled potassium efflux, ...the ...

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The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes

The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes

... One potential concern is that the dosage for SUs needed to adequately control glucose homeostasis may not be enough to resolve neurological symptoms, as SUs have to cross the blood–brain barrier to exert inhibitory ...

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Potential therapeutic targets for hypoxia induced pulmonary artery hypertension

Potential therapeutic targets for hypoxia induced pulmonary artery hypertension

... ATP sensitive potassium channel and the depolarization induced by hypoxia [14]. PAH is a severe disease and ac- counts for most deaths of chronic obstructive pulmonary diseases, and remodeling of the ...

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The pharmacology of calcium and ATP-dependent potassium channels in erythrocytes and in smooth skeletal muscle

The pharmacology of calcium and ATP-dependent potassium channels in erythrocytes and in smooth skeletal muscle

... more sensitive to metabolic ...was sensitive to ...of channels or that full activation of the channels was not achieved in the experiments on mammalian ...of ATP-depletion was not ...

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CFTR is required for PKA regulated ATP sensitivity of Kir1 1 potassium channels in mouse kidney

CFTR is required for PKA regulated ATP sensitivity of Kir1 1 potassium channels in mouse kidney

... pS, ATP-sensitive renal K channel ...both ATP and glibenclamide sensitivities of the 30 pS K channel in TAL cells were absent in mice lacking CFTR and in mice homozygous for the ΔF508 ...in ...

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Nicorandil-Induced Hyperkalemia in a Uremic Patient

Nicorandil-Induced Hyperkalemia in a Uremic Patient

... and ATP-sensitive potassium channel activator ...of potassium channels, potassium ions are expelled out of the cells, which lead to membrane hyperpolarization, closure of ...

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The Mechanism of Preventive Effect of Captopril on Renal Ischemia Reperfusion Injury is Independent of ATP Dependent Potassium Channels

The Mechanism of Preventive Effect of Captopril on Renal Ischemia Reperfusion Injury is Independent of ATP Dependent Potassium Channels

... highly sensitive to small changes in membrane ...such channels contributes to resting blood flow in a number of vascular beds including those of the coronary, mesenteric, skeletal muscle and renal ...

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Comparison of volatile anesthetic-induced preconditioning in cardiac and cerebral system: molecular mechanisms and clinical aspects

Comparison of volatile anesthetic-induced preconditioning in cardiac and cerebral system: molecular mechanisms and clinical aspects

... Numerous studies have demonstrated that sevoflurane and other VAs protect the myocar- dium and brain during I/R injury via the mitochondrial ATP-sensitive potassium (mK ATP ) channels[r] ...

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Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice

Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice

... rents were recorded using a ramp-pulse protocol. The reversal potential was close to the potassium equilibrium potential in ventricular cells of both WT and KO mice (Figure 2, a and b). There was no significant ...

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