ATP-sensitive potassium channels activation
Nicorandil-Induced Hyperkalemia in a Uremic Patient
... and ATP-sensitive potassium channel activator ...After activation of potassium channels, potassium ions are expelled out of the cells, which lead to membrane ...
5
The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection
... for activation of PKC, perhaps by translocation from an inactive state in the cytosol to an active membrane-bound state and its subsequent de-activation, thought to take approximately 60 ...
164
Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction
... Inflammatory response has been considered as a pivotal factor in endotoxemia-induced cardiac dysfunction. Levels of various pro-inflammatory cytokines, such as TNF-α, were considered directly or indirectly contributing ...
8
ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
... K+ATP channels in sen- sitized mice have been influenced by pretreatment of ...the activation of descending noradrenergic system induced by ...K+ATP channels and L-type Ca 2+ ...
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The pharmacology of calcium and ATP-dependent potassium channels in erythrocytes and in smooth skeletal muscle
... more sensitive to metabolic ...was sensitive to ...of channels or that full activation of the channels was not achieved in the experiments on mammalian ...of ATP-depletion was ...
215
The effect of ATP sensitive potassium channel modulation on heart rate in isolated muskrat and guinea pig hearts
... include ATP-sensitive potassium channel activation and extracellular accumulation of potassium ions, hydrogen ions and ...more sensitive to the heart-rate-lowering effects of ...
18
The pharmacology of three inwardly rectifying potassium Channels in neonatal rat cardiac myocytes.
... Action potential duration and activation of the ATP-sensitive K+ current in isolated guinea pig ventricular myocytes. Strong Voltage-Dependent Inward Rectification[r] ...
220
Lactate activates ATP sensitive potassium channels in guinea pig ventricular myocytes
... of ATP at which activation of the channels occurs and the much higher levels of ATP maintained during myocardial ...on ATP-sensitive potassium channels in adult ...
7
Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators
... Ca^* channels, K^ channels and phosphollpases (Andrea and Walsh, ...kinase activation Is MLC phosphorylation and contraction (Somlyo and Himpens, 1989; HIrata et ...
281
The Mechanism of Preventive Effect of Captopril on Renal Ischemia Reperfusion Injury is Independent of ATP Dependent Potassium Channels
... highly sensitive to small changes in membrane ...such channels contributes to resting blood flow in a number of vascular beds including those of the coronary, mesenteric, skeletal muscle and renal ...
5
Activation of potassium channels contributes to hypoxic injury in proximal tubules
... K+ channels were the primary route of K+ ...of ATP-sensitive K+ channels, reduced hypoxic injury as assessed by the release of lactate dehydrogenase or measurement of DNA ...that ...
7
ATP-dependent potassium channels are implicated in simvastatin pretreatment-induced inhibition of apoptotic cell death after renal ischemia/reperfusion injury
... calpain activation (28), we speculated that reduced apoptotic cell death and renal tissue preservation is possibly mediated, at least in part, by this activity of ...
10
Potential therapeutic targets for hypoxia induced pulmonary artery hypertension
... apoptosis [5]. The Kv channel of PASMCs can directly respond to the oxygen tension by controlling resting membrane potential and regulating vasomotor. The Kv1.5 was found as the primary oxygen-sensitive sub- type ...
9
CFTR is required for PKA regulated ATP sensitivity of Kir1 1 potassium channels in mouse kidney
... The cystic fibrosis transmembrane conductance regulator (CFTR) Cl – channel plays vital roles in fluid transport in many epithelia. While CFTR is expressed along the entire nephron, its function in renal tubule ...
12
Mechanisms of the antinociceptive action of (−) Epicatechin obtained from the hydroalcoholic fraction of Combretum leprosum Mart & Eic in rodents
... The activation of 5-HT receptors may cause an increased release of norepinephrine, which activates the post synaptic alpha 2 receptor and leads to an inhib- ition of painful impulse ...The activation of ...
6
Ion Channels in Peripheral Blood Mononuclear Cells – Effect of Culture and Ascorbic Acid.
... Potassium channels in lymphocytes are responsible for the repolarization of membrane during lymphocyte ...lymphocyte activation. Since potassium channels play an important role in ...
126
Regulation of the mitochondrial ATP-sensitive potassium channel in rat uterus cells by ROS
... mitoK ATP , depolarized mitochondrial membrane either under oxidative stress or under normal conditions, while mitoK ATP blocker glyben- clamide effectively restored mitochondrial poten- tial in rat ...
10
In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root
... other potassium channel inhibitors, including 4-AP and glipizide, showed significant inhibi- tion of oroxylin A-induced relaxation with IC 50 values of ...these potassium channel antagonists, TEA appeared ...
7
Physiology of rat retinal pericytes: modulation of ion channel activity by serum derived molecules
... Traditionally, pericytes have been thought to be similar in many ways to vascular smooth muscle cells. For example, both cell types are derived from the mesenchyme, are closely associated with the vascular endothelium ...
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The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes
... sensitivity of the channel will only be substantially impaired when all four subunits contain the mutation; otherwise, the mutant Kir6.2 subunit’s effects will be largely compensated for by the presence of the other ...
17