ATP-sensitive potassium (channels, current)
The effect of ATP sensitive potassium channel modulation on heart rate in isolated muskrat and guinea pig hearts
... extracellular potassium concentration that occur during hypoxia are thought to be mediated by the ATP-sensitive potassium ...These channels open and allow potassium to pass under ...
18
Glucose modulates rat substantia nigra GABA release in vivo via ATP sensitive potassium channels
... on ATP-sensitive potassium (KATP) ...of ATP by perfusion of 2-deoxyglucose with oligomycin inhibited GABA release by 44 +/- 8 and 45 +/- 11%, ...KATP channels and that inhibition of ...
7
Lactate activates ATP sensitive potassium channels in guinea pig ventricular myocytes
... of ATP at which activation of the channels occurs and the much higher levels of ATP maintained during myocardial ...on ATP-sensitive potassium channels in adult guinea pig ...
7
The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes
... (ATP)-sensitive potassium (K ATP ) channel ...K ATP channel activity couples glucose metabolism to insulin secretion via cellular excitability and mutations in either KCNJ11 or ABCC8 ...
17
Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats
... KATP: ATP-sensitive potassium channels; HR: heart rate; STZ: streptozotoxin; CO: cardiac output; ...inward-rectifier potassium ion channels ...
9
ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
... calcium channels (Ca2+ channels) and ATP-sensitive potassium channels (K+ channels) in hyperalgesia induced by morphine in dia- betic ...
8
ATP sensitive potassium channels mediate contraction induced attenuation of sympathetic vasoconstriction in rat skeletal muscle
... In our experiments, glibenclamide also attenuated active hyperemia, which is consistent with previous studies in the ca- nine diaphragm (35, 36) and hamster cremaster muscle (37). We therefore considered the possibility ...
9
Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia
... gated potassium channels have been shown to be one of the key regulators of HPV [5], but in candidates like ...contrast, ATP sensitive K-channels (KATP) were demonstrated to be ...
10
Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction
... channels may offer protection against apoptosis in endotoxemia [10]. Thus, the first aim of this work was designed to assess the role of Kir6.2 subunits on cardiac function and cardiac damage under LPS ...
8
Regulation of the mitochondrial ATP-sensitive potassium channel in rat uterus cells by ROS
... mitoK ATP , depolarized mitochondrial membrane either under oxidative stress or under normal conditions, while mitoK ATP blocker glyben- clamide effectively restored mitochondrial poten- tial in rat ...
10
Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators
... 1997), channels are a likely target for mediating at least some of the effects of ...BKca channels can be activated by NO either directly, via nitrosylation of channel proteins ...K atp (Murphy and ...
281
An investigation of the biochemical interaction between subunits of the ATP-sensitive potassium channel
... deoxycholate and Triton X-100; Gilead et. al., 1975) if problems are observed with non-specific co-immunoprecipitation, as it will break all but the strongest protein- protein interactions. However, it is a fine balance ...
302
Curcumin inhibits proliferation of gastric cancer cells by impairing ATP sensitive potassium channel opening
... has decreased remarkably in the past few years [22]. However, globally, gastric cancer is now the second lead- ing cause of mortality in malignant diseases [1]. The prognosis of patients with gastric cancer is poor, ...
8
Expression of ATP-sensitive potassium channels in human pregnant myometrium
... Human myometrium undergoes dramatic physiological and biochemical changes during pregnancy and parturi- tion. Myometrium remains in a relatively quiescent state during most time of pregnancy, but it develops the highly ...
7
Functional cell biology and molecular pharmacology of ATP sensitive potassium channels
... the ATP-binding cassette (ABC) or transport ATPase ...for ATP hydrolysis and an aspartate residue in the Walker B motif is involved in coordinating the magnesium ion of the magnesium ...
125
The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection
... the current study are consistent with these previous studies. In the current study three hearts receiving the preconditioning protocol either failed to precondition or protection was lost prior to sustained ...
164
Potential therapeutic targets for hypoxia induced pulmonary artery hypertension
... ATP sensitive potassium channel and the depolarization induced by hypoxia ...the current study, Changes in Δψm, as indi- cated by the intensity of R-123 ...mitoK ATP channels was ...
9
Nicorandil-Induced Hyperkalemia in a Uremic Patient
... and ATP-sensitive potassium channel activator ...of potassium channels, potassium ions are expelled out of the cells, which lead to membrane hyperpolarization, closure of ...
5
Conversion of amylase secreting rat pancreatic AR42J cells to neuronlike cells by activin A
... recording of the membrane patch revealed the existence of ATP-sensitive potassium channel in activin-treated cells. These results indicate that activin A converts amylase- secreting AR42J cells to ...
12
Comparison of volatile anesthetic-induced preconditioning in cardiac and cerebral system: molecular mechanisms and clinical aspects
... Numerous studies have demonstrated that sevoflurane and other VAs protect the myocar- dium and brain during I/R injury via the mitochondrial ATP-sensitive potassium (mK ATP ) channels[r] ...
10