auditory hair cells
Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization
... V-shaped hair bundles atop auditory hair cells and their uniform orientation are manifestations of epithelial planar cell polarity (PCP) required for proper perception of ...the hair ...
11
Kif3a regulates planar polarization of auditory hair cells through both ciliary and non ciliary mechanisms
... sensitivity, hair bundles in the cochlea must be uniformly oriented for correct perception of ...the auditory sensory epithelium, the organ of Corti (OC), the vertex of the V-shaped hair bundle on ...
9
Sorting nexin 9 (SNX9) is not essential for development and auditory function in mice
... mouse auditory hair cells and might regulate actin polymerization in those ...of auditory hair cells are not affected by Snx9 inactivation, and Snx9 knockout mice have normal ...
12
Manipulation of BK channel expression is sufficient to alter auditory hair cell thresholds in larval zebrafish
... in auditory hair ...these cells is an outward calcium-activated potassium current that flows through large-conductance calcium- activated potassium (BK) ...change auditory thresholds in fish, ...
9
Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo
... and hair cell ...ear cells with different specificities and expression levels, depending on the type of adenoviral vectors and the age of ...including auditory hair cells and supporting ...
9
Auditory Dysfunction in Aging: Prospects for Stem Cell Therapy
... exposing cells to various cellular stresses including oxida- tive ...of hair cells and inhibition of potas- sium secretion in strial marginal ...destroy auditory hair cells, ...
19
Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice
... of hair cells (44 –47) although recent studies suggest that under normal con- ditions, protein and actin turnover is fairly slow in mature stereo- cilia, except at their distal tip (48,49) where the barbed ...
13
Growth factor eluting cochlear implant electrode: impact on residual auditory function, insertional trauma, and fibrosis
... protecting auditory hair cells (HCs) against damage caused by intense noise exposure [14,15], drug-induced hearing loss [16], or ischemic injury [17], with no adverse ...
9
Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes
... utricle hair cells are summarized in Figure 5B. In hair cells with intermediate geno- types, we analyzed the 10%–90% operating range of stimulus-response relationships, but found no ...
15
Hair cells, hearing and hopping: a field guide to hair cell physiology in the frog
... frog auditory system. Information about the physiology of frog auditory hair cells has been much slower in coming, but has benefited greatly by the overall advances made in the field of ...
10
Seasonal plasticity of auditory hair cell frequency sensitivity correlates with plasma steroid levels in vocal fish
... midshipman auditory physiology (Sisneros, 2009; Sisneros and Bass, 2003) (current study) but little progress has been made in identifying the mechanism(s) of such plasticity except for identifying that it can be ...
12
Sexually dimorphic swim bladder extensions enhance the auditory sensitivity of female plainfin midshipman fish, Porichthys notatus
... in auditory pressure sensitivity between type I males and females maybe more related to the relative distance between the saccule and the anterior end of the swim bladder in males and ...
11
Linear and nonlinear processing in hair cells
... Mechanosensory hair cells in the ear are exquisitely responsive to minute sensory inputs, nearly to the point of ...of hair cells, and their responses to small perturbations that correspond to ...
6
Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea
... hair cells. (A) Relative Atoh1 mRNA levels in the cochlea increase during hair cell ...E17.5 hair cells (right, Atoh1-GFP ...and hair cells, and in control cell types ...
9
Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses.
... the auditory brainstem are still not understood [22], and their specific influence over IHC function and development will only become evident by performing extremely challenging in vivo ...
9
Dual AGC Model Implementation of the Inner Hair Cell and Auditory Nerve IC in Neuromorphic VLSI
... ABSTRACT-An analog inner hair cell and auditory nerve has been implemented for the persons with hearing disabilities. The designed circuit uses fully balanced circuits to reduce the mismatch of the signals ...
12
Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain
... defective, hair bundles maintain intrinsic polarity but are randomly polarized in the apical cell ...between hair and support cells is not affected in ciliary mutants (Jones et ...and hair ...
11
The Actin-Binding Proteins Eps8 and Gelsolin Have Complementary Roles in Regulating the Growth and Stability of Mechanosensory Hair Bundles of Mammalian Cochlear Outer Hair Cells
... the auditory afferent ...of hair cells to form hair-like bundles ...each hair bundle, the overall size and shape of which depends on location along the cochlea ...
8
Stem cells for the replacement of inner ear neurons and hair cells
... transplanted cells at the time of infusion. The stage at which hair cell progenitors are transplanted could have a major effect on their ability to interact with the proper cells in the sensory ...
8
PubMedCentral-PMC5515907.pdf
... With these features of the ECochG signal in mind, the goal of this study is to subjectively characterize the presence of neural compared to hair cells components in the responses to tones of children with ...
16