Aurora B
Dictyostelium Aurora Kinase Has Properties of both Aurora A and Aurora B Kinases
... Dictyostelium Aurora has the dynamic distribution of both Aurora A and Aurora B ...like Aurora A or Aurora B, we examined the dynamic localization of GFP-tagged DdAurora ...
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Inhibition of Aurora B by CCT137690 sensitizes colorectal cells to radiotherapy
... [9,11]. Aurora A overexpression has been observed in vari- ous cancers including colorectal ...of Aurora A protein in 19% of CRC by immunohistochemistry ...the Aurora A gene was found in colorectal ...
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Original Article Let-7g reverses malignant phenotype of osteosarcoma cells by targeting Aurora-B
... Primers were designed in accordance with the human Aurora-B (AURKB) gene (NM_004217.3) sequences. And a fragment of the 3’-UTR of AURKB was amplified from U2-OS cells by PCR using the forward primer ...
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Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases
... against Aurora A, Aurora B and VEGFR2 ...with Aurora A and B ...potential Aurora A and B inhibitor by HTRF® KinEASE ™ ...cellular Aurora A and B activities ...
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Specific distribution of overexpressed aurora B kinase in interphase normal epithelial cells
... overexpressed aurora B in the nucleus we observed here (Figure 1a', arrowhead) appeared to be different from that was observed in prophase cells ...that aurora B localized to the centromeres ...
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Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design
... for Aurora-A over Aurora-B in cell-based assays and the compound can be used to obtain a cellular phenotype consistent with clear discrimination [13, ...The Aurora-A activator TPX2 reduces the ...
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Changing Roles of Aurora-B Kinase in Two Life Cycle Stages of Trypanosoma brucei
... the aurora-B kinase in regulating chromosome seg- regation in yeasts and metazoans have been well documented (2, 8, ...12). Aurora-B forms the chromosomal passenger com- plex with three ...
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Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.
... The pRB tumor suppressor pathway includes p16, Cyclin D1, and CDK4, which control pRB phosphorylation and its ability to repress E2F [9]. Many types of cancer have pRB pathway mutations without a strong bias toward any ...
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Let-7a inhibits osteosarcoma cell growth and lung metastasis by targeting Aurora-B
... Aurora-B (AURKB) is a component of chromosome pas- senger complex (CPC), which is composed of additional three activation regulators such as INCEP, survivin and borealin. AURKB plays important biological ...
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The Aurora B Kinase Promotes Inner and Outer Kinetochore Interactions in Budding Yeast
... for Aurora B-mediated phos- phorylation of Dsn1 might be ...of Aurora B phosphorylation, leading to loss of their interaction during ...by Aurora B promotes outer kinetochore ...
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Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma
... screen, aurora kinase inhibitors (nine molecules) and in particular the AURKB-selective compound, barasertib, were the most discriminatory with regard to sensitivity for MYCN-amplified cell ...Therefore, ...
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Butein suppresses hepatocellular carcinoma growth via modulating Aurora B kinase activity
... human Aurora B ...the Aurora B kinase in the cell lysates was demonstrated to be interacted with butein-Sepharose 4B beads (Figure 3B), however, the Aurora A/C kinase didn’t bind with ...
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Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.
... or Aurora B inhibition prevented MAD1 kinetochore recruitment, this should prevent centrosomal accumulation following NDGA ...that Aurora B activity is not essential for MAD1 recruitment to ...
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Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development
... of aurora B-deficient ...encoding aurora B contains eight exons (boxes) containing non-coding (open boxes) or protein-coding (gray boxes) ...flank aurora B exons or the ...
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Assessing the role of Ku70 vWA domain phosphorylation in the inhibition of Aurora B and activation of the DNA damage response
... demonstrating Aurora B association with Ku70 S155D, the results of in vitro kinase assay demonstrate that bacterially expressed Ku70 S155D vWA domain is capable of inhibiting Aurora B kinase ...
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Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.
... following Aurora B inhibition is due to its removal from the kinetochore, at least partially via dynein-mediated stripping, which NDGA treatment allows us to ...
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Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy
... between Aurora B kinase pathway and Raf/MEK/Erk sig- naling in cells, in which the last is affected by the estab- lishment of resistance to vemurafenib, and on the study of the crosstalk between the ...
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Klein, Ulf (2009): The chromosomal passenger complex during mitotic progression: Identification of subunit-specific functions. Dissertation, LMU München: Fakultät für Biologie
... holo-CPC, Aurora B and INCENP can form a separate, independent complex (Gassmann et ...GFP-Aurora B exhibits a dynamic behaviour at the centromere, exchanging rapidly with a cytoplasmic pool ...
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Neuroblastoma treatment in the post-genomic era
... The serine/threonine kinases Aurora A (AURKA) and Aurora B (AURKB) are crucial regulators of the cell cycle. Their coding genes differ in subcellular distribution and the protein products in their ...
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Mps1 regulates kinetochore microtubule attachment stability via the ska complex to ensure error free chromosome segregation
... component of the inner centromere-localized chromosome passenger complex (CPC)) destabilizes improper attachments via phosphorylation of the Ndc80 complex, the microtubule depolymerase MCAK, and other substrates (Kelly ...
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