Aurora kinase
The Agrobacterium VirD5 protein hyperactivates the mitotic Aurora kinase in host cells
... We showed recently that the Agrobacterium virulence protein VirD5 is located at the kinetochores in host cells and causes chro- mosome mis-segregation (Zhang et al., 2017). Binding to the kinetochores is dependent on an ...
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DESIGN SYNTHESIS OF NOVEL ACRIDINE TAGGED PYRAZOLE DERIVATIVES AS AURORA KINASE INHIBITORS
... of Aurora kinases detected in wide variety of human cancers strongly indicate that high expression of these kinases plays an important role in the development of anticancer molecules as aurora kinase ...
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Screening of diverse phytochemicals with Aurora Kinase C protein: An In Silico approach
... Aurora Kinase C protein, which thus serves as a promiscuous target for cancer therapy have been further explored through computational approaches such as protein modeling and have been chosen as a Protein ...
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Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells
... Because HDAC proteins are aberrantly expressed in many types of cancers and have nonredundant functions in con- trolling the hallmark phenotypes of cancer cells [15], we ex- amined HDAC expression after treatment with an ...
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Delivery of DNAzyme targeting aurora kinase A to inhibit the proliferation and migration of human prostate cancer
... (MMP-9), aurora kinase A, and β -actin, horseradish peroxidase (HRP)-labeled goat anti-rabbit immunoglobulin G and HRP-labeled goat anti-mouse immunoglobulin G were obtained from Abcam ...
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Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma
... is Aurora kinase ...of Aurora B inhibition. The specific inhibition of Aurora kinase B was achieved in MYC- overexpressing medulloblastoma cells with ...upon Aurora B ...to ...
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Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
... any Aurora kinase inhibitor that has been previously tried in the ...of Aurora kinase inhibitors may be due to weakening of INCENP binding and/or alteration of substrate ...
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Aurora kinase A revives dormant laryngeal squamous cell carcinoma cells via FAK/PI3K/Akt pathway activation
... recurrence. Aurora kinase A (AURKA), a member of the Aurora serine/threonine kinase family [51], occurs from late G2 and M phase, whereas resting cells have low or undetectable levels of this ...
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Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis
... The Aurora Kinase B is the component of the chromosome passenger protein complex which partici- pate in the chromosome condensation, spindle assembly, segregation of sister chromatids and ...that ...
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EBNA3C regulates p53 through induction of Aurora kinase B
... serine/threonine kinase that plays multiple roles which are integral to accurate cell division ...other aurora kinase AK-A, and may not be regulated by AK-B [29, ...
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Midostaurin preferentially attenuates proliferation of triple-negative breast cancer cell lines through inhibition of Aurora kinase family
... members, Aurora kinases A, B, and C, and the inhibitors identified by the clustering analysis, VX-680 and GSK1070916, are so-called pan-Aurora kinase inhibitors, which suppress all Aurora ...
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Aurora Kinase A and Gastrointestinal Malignancies
... In non-colorectal gastrointestinal cancers, a number of studies have highlighted the poor prognostic impact of AURKA protein overexpression or gene amplification. Greater than 50% of upper GI cancers demonstrate ...
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Dictyostelium Aurora Kinase Has Properties of both Aurora A and Aurora B Kinases
... kinases, Aurora A and B, which contribute distinct functions at the spindle poles and the equatorial region ...ancestral kinase. We show that Dictyostelium discoideum contains a single Aurora ...
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Aurora Kinase Inhibition Overcomes Cetuximab Resistance in Squamous Cell Cancer of the Head and Neck
... the Aurora kinases as potential targets in this disease. Aurora kinases are upregulated in multiple human cancers, correlating in some cases with poor prognosis [18, 20-21, ...both Aurora-A and EGFR ...
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Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors
... serine/threonine kinase and FOXM1 transcription factor in the putative stem cell compartment of CML, identified by CD34+ phenotype, and their role in BCR-ABL1+ LSC persistence under TK inhibitor therapy ...to ...
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Evaluation of the Aurora Kinase Inhibitor, ZM447439, in Canine Malignant Lymphoid Cells in Vitro
... of aurora-A and aurora-B was also evaluated by western ...of aurora- A and aurora-B were noted in the canine malignant lym- phoid cell lines, which is a finding similar to the RT-PCR ...The ...
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Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells
... the Aurora kinases and a third-generation Bcr-Abl tyrosine kinase inhibitor with potent anticancer effects, but its antitumor effect and underlying mechanisms in the treatment of human gastric cancer are ...
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The functional diversity of Aurora kinases: a comprehensive review
... Protein Kinase C; AIK: Aurora/IPL1-related kinase; ARK: Aurora-related kinase; AURK: Aurora kinase; Aur: Aurora; ARD1: Arrest Defective Protein 1; ATM: ataxia ...
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Computational design, synthesis, characterization and pharmacological evaluation of some piperidine derivatives.
... Hypo-1 was used to screen 61 Aurora kinase A inhibitors of known high, medium and low active inhibitors of the test set the data are presented in Table 6.3. Database mining was performed in Catalyst ...
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Inhibition of Aurora B by CCT137690 sensitizes colorectal cells to radiotherapy
... In the current study, we sought to identify whether the combination of radiotherapy and inhibition of Aurora ki- nases could exert a synergistic inhibitory effect on colo- rectal cancer cell growth. To test this ...
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