Aurora A kinase activity is required for the
Butein suppresses hepatocellular carcinoma growth via modulating Aurora B kinase activity
... of Aurora B with shRNA substantially inhibited HCC cell proliferation, colony formation and delayed tumor growth in nude ...of kinase assays revealed butein directly interacted with Aurora B and ...
14
Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes
... UL97 kinase activity produce large nuclear aggregates that sequester considerable quantities of viral ...UL97 kinase activity inhibited their ...a kinase- dependent ...UL97 ...
14
Autophosphorylation Within the Atg1 Activation Loop Is Required for Both Kinase Activity and the Induction of Autophagy in Saccharomyces cerevisiae
... Autophagy activity appears to be highly regulated and multiple signaling pathways are known to target a complex of proteins that contains the Atg1 protein ...protein kinase activity and a failure to ...
12
Rapamycin-Resistant mTORC1 Kinase Activity Is Required for Herpesvirus Replication
... Torin1 does not affect HCMV entry and only modestly reduces the accumulation of the immediate-early and early viral proteins that were tested despite the disruption of the eIF4F complex. In contrast, Torin1 significantly ...
10
Dictyostelium Aurora Kinase Has Properties of both Aurora A and Aurora B Kinases
... eukaryotes, Aurora kinases are known to function during multiple stages of cell ...The activity of Aurora kinases regulates almost every crucial stage of M phase, from chromosome condensation and ...
12
Switching Aurora-A kinase on and off at an allosteric site
... with Aurora-A, the HV2/CDR1 region of vNAR- D01 contacts the activation loop of Aurora-A, an interaction that could be manipulated to further enhance inhibition through stabilization of an inactive ...
19
Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain
... GAK activity in solution: NbGAK_4 modes- tly enhanced kinase activity, while NbGAK_1 had no ...protein kinase 1 (TgCDPK1) consists of a catalytic domain and a regulatory domain that either ...
10
Increased biological activity of protein Kinase C gamma is not required in Spinocerebellar ataxia 14
... γ kinase activity We had reported earlier that transgenic mice with the PKCγ mutation S361G [16] show mild ataxia and strong abnormalities of dendritic growth of Purkinje cells in cerebellar slice culture ...
11
The Dynamic Localization and Novel Functions of the. Ipl1/Aurora Protein Kinase
... Figure 3.2.6. Ipl1p’s kinase activity is not required for its localization. (A) ipl1-as5- GFP mutant cells (SBY1356) were arrested in G1 using α-factor and then released in the cell cycle in the ...
161
The Agrobacterium VirD5 protein hyperactivates the mitotic Aurora kinase in host cells
... Ipl1/ Aurora kinase activity is known to cause spindle instability, explaining enhanced chromosome mis-segregation seen in the presence of ...Ipl1/Aurora kinase at least partially ...
10
Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma
... screen, aurora kinase inhibitors (nine molecules) and in particular the AURKB-selective compound, barasertib, were the most discriminatory with regard to sensitivity for MYCN-amplified cell ...AURKB ...
16
Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic
... of Aurora-A is frequently used as a cel- lular readout of Aurora-A activity and of the extent of enzyme FIGURE ...the kinase activation loop. a, Aurora-A; b, PKA; c, p38 ␣ ; d, CDK2; e, ...
9
Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors
... /cyclosome (APC/C)-cadherin 1 (Cdh1) following inactiva- tion by protein phosphatase 1γ (PP1γ) and PP2A de-phosphorylation [32–34]. Once activated, AURKA im- pacts on multiple targets involved in centrosome matur- ation, ...
11
A phase I trial investigating the Aurora B kinase inhibitor BI in combination with
... were required to be eligible for low-dose cytarabine treatment and to be considered ineligible for intensive ...that required treatment, known acute myeloid leukaemia central nervous system involvement, or ...
24
Role of aurora kinase B in regulating resistance to paclitaxel in breast cancer cells
... protein kinase domain and a C-terminal ...other Aurora kinase subtypes ...other Aurora kinase ...is required concerning the mechanism by which AURKB exerts negative regulation of ...
16
Evaluation of the Aurora Kinase Inhibitor, ZM447439, in Canine Malignant Lymphoid Cells in Vitro
... be required to bet- ter understand the RNA level expression of aurora kinas- es in canine malignant lymphoid ...of aurora-A and aurora-B was also evaluated by western ...of aurora- A ...
10
Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.
... apo kinase is in equilibrium with inhibited kinase in an inactive T-loop ...e) Kinase activity assay for unlabeled pseudo-wildtype Aurora A ( & ) and TMR-labeled K224C/S283C ( ~ ...
7
Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.
... of Aurora-A required for N-Myc binding is incompatible with the conforma- tion induced by kinase inhibitors that disrupt the ...of Aurora-A bound to N-Myc (PDB ID code 5G1X), MLN8054 (PDB ID ...
6
The Aurora B Kinase Promotes Inner and Outer Kinetochore Interactions in Budding Yeast
... Ipl1 kinase activity than other Aurora-dependent functions (Kotwaliwale et ...well-established Aurora B substrate, often remains phosphorylated upon Au- rora B inactivation ...
10
Aurora Kinase Promotes Turnover of Kinetochore Microtubules to Reduce Chromosome Segregation Errors
... of Aurora kinase activity by ZM447439 at a dose, 3 mM, that has little effect on his- tone phosphorylation, metaphase chromosome align- ment, and cytokinesis in PtK1 ...Partial Aurora ki- nase ...
8