autocrine growth
Leukemoid reaction and autocrine growth of bladder cancer induced by paraneoplastic production of granulocyte colony stimulating factor – a potential neoplastic marker: a case report and review of the literature
... Case presentation: A 39-year-old Caucasian woman with an invasive high-grade urothelial carcinoma presented with hematuria and low-grade fevers. Laboratory tests revealed an elevated white blood cell count and absolute ...
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Identification of interleukin-6 as an autocrine growth factor for Epstein-Barr virus-immortalized B cells.
... Autocrine growth factor activity in these supernatants was assessed by a 3-day culture of lymphoblastoid cells that had been starved by incubation for 24 h at a cell density of 5 x 105/m[r] ...
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Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II
... hypertrophic growth of vascular smooth muscle cells (VSMC). Accompanying this growth is the induction of the expression of growth-related protooncogenes (c-fos, c-jun, and c-myc), as well as the ...
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Understanding the roles of growth factors in carcinogenesis: modulation of autocrine growth control by differentiation
... [nt I 0 , iii,,! 37 61 65 (1993) 61 Understanding the roles of growth factors in carcinogenesis modulation of autocrine growth control by differentiation ANGIE RIZZINO' Eppley Institute for Research i[.] ...
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FGF19 functions as autocrine growth factor for hepatoblastoma
... To gain insight into cytokine signaling in hepatoblastoma, we employed mass spectrometry to analyze the proteins secreted from Hep293TT hepatoblastoma cell line we established and identified the specific secretion of ...
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Autocrine, Mitogenic Pheromone Receptor Loop of the Ciliate Euplotes raikovi: Pheromone-Induced Receptor Internalization
... prototypic autocrine growth factors and paracrine mating (sex- ual) signals ...their growth and de- velop competence for uniting in mating pairs ...an autocrine response and the response to ...
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Suramin, an experimental chemotherapeutic drug, activates the receptor for epidermal growth factor and promotes growth of certain malignant cells
... disrupting autocrine growth involving coexpression of platelet-derived growth factor and its receptors in a fibroblast model for mesenchymal ...
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Determination of GP88 (progranulin) expression in breast tumor biopsies improves the risk predictive value of the Nottingham Prognostic Index
... Background: The Nottingham Prognostic Index (NPI), which combines numerical values for nodal status, tumor size and histological grade, is used in the standard of care to provide predictive value information on ...
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Bombesin and bombesin antagonists: Studies in Swiss 3T3 cells and human small cell lung cancer
... Bombesin-like peptides are potent mitogens for Swiss 3T3 cells Rozengurt & Sinnett-Smith, 1983 and have attracted interest as possible autocrine growth factors for small cell lung cancer[r] ...
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Insulin like growth factor 1 acts as an autocrine factor to improve early embryogenesis in vitro
... other growth factors present at high density can overcome the loss of IGF1R signalling, possibly by activating the PI3K/Akt ...proposed autocrine factors, such as TGF a , PDGF a and PAF (reviewed in (Hardy ...
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TGFβ family signaling: novel insights in development and disease
... the autocrine growth inhibition by TGF, which complements the increased proliferation executed by increased TGF release and epidermal growth factor (EGF) receptor signaling in response to TACE ...
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An Essential Role for Macrophage Migration Inhibitory Factor (MIF) in Angiogenesis and the Growth of a Murine Lymphoma
... (IL-1), IL-2, hematopoietic colony-stimulating factors (CSFs), platelet-derived growth factor (PDGF), and transforming growth factor (31 (TGF-j31) each can act as an autocrine growth fac[r] ...
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Interleukin-8/CXCL8 is a growth factor for human lung cancer cells
... of growth of the two human NSCLC cells lines A549 and Calu-1 in SCID ...cancer growth through its angiogenic ...an autocrine growth factor for the proliferation of NSCLC cells (Arenberg et al, ...
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1,25 Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin 1beta production
... The growth inhibition was associated with a rapid but transient downregulation of IL-1beta and IL-1beta-converting enzyme (ICE) mRNAs in 1,25D3- and 20-epi analogue- treated cells, and the 20-epi analogue was more ...
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L triiodothyronine stimulates growth by means of an autocrine factor in a cultured growth hormone producing cell line
... responsive growth hormone (GH)-secreting cell ...an autocrine growth factor, we compared the growth-promoting activity of medium conditioned by T3-stimulated and T3-depleted cells to that of ...
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TGF-β1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases
... In this study we have demonstrated that TGF- β 1 increases proliferation in serum-free condition and enhances serum-induced proliferation of confluent ASMCs. This observation is consistent with the reports of others in ...
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Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism
... To evaluate the mechanism by which CML-exosomes are able to sustain tumor growth, we tested the expression of different molecules involved in the apoptotic machinery. As shown in Figure 2a, LAMA84 treated for 72, ...
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Vascular endothelial growth factor regulates osteoblast survival – evidence for an autocrine feedback mechanism
... Abnormalities in cell death control contribute to a variety of diseases including cancer, autoimmunity, degenerative disorders and osteoporosis [1,2,17,23]. Signaling for apoptosis occurs through multiple independent ...
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The Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Has Broad Signaling Effects in Primary Effusion Lymphoma Cells
... Important growth and angiogenic factors like VEGF are influenced by vGPCR, and in NIH 3T3 cells, vGPCR is directly ...cell growth can be studied more ...
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Basic Fibroblast Growth Factor Autocrine Loop Controls Human Osteosarcoma Phenotyping and Differentiation
... role of endogenous release in controlling the os- teoblast phenotype. In support of this hypothesis in fact, bFGF, even without typical leader sequences, has been shown to be secreted by living and responsive cells ...
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