Autocrine loop
Induction of a negative autocrine loop by expression of sst2 somatostatin receptor in NIH 3T3 cells
... The somatostatin receptor subtype sst2 mediates both acti- vation of a tyrosine phosphatase activity and inhibition of cell proliferation induced by somatostatin analogues. In the absence of exogenous ligand, expression ...
11
Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop
... Figure 7: S1P-induced epithelial to mesenchymal transition (EMT) was mediated by syndecan-1 and TGF-β1. HepG2 control and syndecan-1 shRNA cells were treated with 2 μM S1P for 72 h with or without an addition of 5 μg/ml ...
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Basic Fibroblast Growth Factor Autocrine Loop Controls Human Osteosarcoma Phenotyping and Differentiation
... an autocrine loop involving the bFGF pathway may be implicated in the expres- sion of different maturation stages, thus modulating tumour cell ...an autocrine loop may represent an additional ...
12
TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes
... In this study we have demonstrated that XBP1 activation is implicated in RA pathogenesis and that this is uncoupled from a canonical UPR signature in this disease. Furthermore, XBP1 splicing is induced in response to TLR ...
8
The autonomous growth of human papillomavirus type 16-immortalized keratinocytes is related to the endothelin-1 autocrine loop.
... receptor antagonist, BQ123. The pathophysiologic role of the ET-1 autocrine loop in keratinocyte proliferation is open to speculation. As postulated for the EGFR, the increase of ET-1 receptors enhances the ...
7
GDNF protects enteric glia from apoptosis: evidence for an autocrine loop
... Together with our aforementioned finding that EGC express all receptors for GDNF and in addition, produce high amounts of GDNF in bowel inflammation [10], these results allow us to hypothesize the existence of an ...
8
Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells
... IL-6 autocrine loop might contribute to SDF-1α-induced GEM chemoresistance in ...IL-6 autocrine loop in PCCs might be an effective target for blocking SDF-1α-mediated PSC-PCC ...interactions. ...
13
Interferon gamma induces prostaglandin G/H synthase 2 through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells
... The bronchial epithelium is known to modify its phenotype in response to an inflammatory microenvironment. For example, we reported that IFN- g, IL-1b, and/or TNF-a mediates the up- regulation of Type II nitric oxide ...
8
An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer
... In summary, we demonstrate the utility of IL-6-induced EMT models in vitro to identify potential therapeutic targets in this otherwise largely treatment-refractory subpopulation. We show that IGF-1R has an important role ...
10
Autocrine stimulation of VEGFR 2 activates human leukemic cell growth and migration
... In this report, we demonstrate that primary leukemias and leukemic cell lines produce VEGF, and subsets of human acute leukemias express functional VEGF receptors, namely, VEGFR-2. On VEGFR- 2–positive leukemias, ...
12
Tumor VEGF:VEGFR2 autocrine feed forward loop triggers angiogenesis in lung cancer
... feed-forward loop that is mediated by a VEGFR2/PI3K/mTOR/VEGF signaling ...feed-forward loop stimulating VEGF secretion in a VEGFR2-de- pendent fashion, VEGF secretion was strongly induced by addi- tion of ...
10
Targeting TACE dependent EGFR ligand shedding in breast cancer
... The ability to proliferate independently of signals from other cell types is a fundamental characteristic of tumor cells. Using a 3D culture model of human breast cancer progression, we have delineated a protease- ...
10
Suramin, an experimental chemotherapeutic drug, activates the receptor for epidermal growth factor and promotes growth of certain malignant cells
... investigated the efficacy of suramin in a carcinoma model system. Our findings demonstrate that suramin enhances cell surface signaling in A431 cells by activating an autocrine loop involving the receptor ...
7
Lipopolysaccharide induces the expression of an autocrine prolactin loop enhancing inflammatory response in monocytes
... an autocrine loop of PRL in lymphocyte [6-8] implies that PRL and its re- ceptor (PRLr) must be synthesized and that the ligand is also secreted for the same cell; as well as, that this released PRL has a ...
12
Leukemoid reaction and autocrine growth of bladder cancer induced by paraneoplastic production of granulocyte colony stimulating factor – a potential neoplastic marker: a case report and review of the literature
... Case presentation: A 39-year-old Caucasian woman with an invasive high-grade urothelial carcinoma presented with hematuria and low-grade fevers. Laboratory tests revealed an elevated white blood cell count and absolute ...
6
The Design for the Boiler Drum Level System Based on Immune Control
... Cascade control is widely used in power plant. deputy loop acts as a "coarse" role, while main circuit is used to perform "fine tune". The effect of two regulators in cascade control system is ...
6
Lec 13 JavaScript - III.pptx
... If the condition evaluates to a ‘false’ value, the ‘for’ loop finishes looping. Otherwise, the ‘for’ loop goes through the loop.[r] ...
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High Levels Production of Recombinant Human Activin A—Effect upon in Vivo Follicle Stimulation
... Activin A also promotes increase in LH expression and may regulate the production of LH, controlling LH beta subunit expression [40] [41]. The main function of LH refers to the maturation of ovarian follicles after ...
10
Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitro
... Autonomous colony formation is a frequent event in erythroleukemia. In 13 cases of early erythroid leukemias, we investigated whether erythropoietin (Epo) autocrine stimulation was responsible for the growth ...
10
Periapical infection and the inflammatory radicular cyst
... It is postulated that growth of radicular cysts involves endotoxin stimulation of the epithelium, the autocrine stimulation of cyst epithelial cell division by IL-1 [r] ...
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