Autocrine/paracrine
Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma
... that autocrine expression of hGH or hPRL in HCC cells increased STAT3 activation, oncogenicity and tumor growth while functional antagonism with hGH-G120R significantly reduced these ...as ...
15
Evaluation of the role of paracrine/autocrine IGF-1 system in skeletal muscle adaptation
... The striking loss o f skeletal muscle mass and strength that occurs in very old animals and humans has been attributed to a number of different effects including impaired muscle regeneration, under-nutrition and lack of ...
145
Endothelin 1 is synthesized and inhibits cyclic adenosine monophosphate dependent anion secretion by an autocrine/paracrine mechanism in gallbladder epithelial cells
... chromatography. The cells also displayed ET receptor mRNAs and high-affinity binding sites for ET-1, mostly of the ETB type. Electrogenic anion secretion across intact gallbladder mucosa was stimulated by forskolin, ...
9
Endothelin 1 is an autocrine/paracrine factor in the mechanism of angiotensin II induced hypertrophy in cultured rat cardiomyocytes
... Abstract To elucidate the cellular mechanism by which angiotensin II ANG II induces cardiac hypertrophy, we investigated the possible autocrine/paracrine role of endogenous endothelin-1 [r] ...
7
Interleukin 6 A potential autocrine/paracrine factor in Paget's disease of bone
... conditioned by these atypical multinucleated cells (MNC) to determine if pagetic osteoclasts produce an autocrine or paracrine factor that enhances osteoclast formation. Conditioned media from long-term ...
8
Autocrine and Paracrine Promotion of Cell Survival and Virus Replication by Human Herpesvirus 8 Chemokines
... via autocrine signaling, virus reactivation ex- periments were undertaken in TIME-CCR8 i cell lines and “pooled” transformants ...and paracrine signaling inhibition ...
13
Corticotropin releasing hormone is produced by rat corticotropes and modulates ACTH secretion in a paracrine/autocrine fashion
... Anterior pituitary hormone secretion is mainly regulated by hypothalamic releasing factors, which reach the pituitary via portal vessels. It has been demonstrated recently that these peptides can also be produced by the ...
8
Pheromones Stimulate Mating and Differentiation via Paracrine and Autocrine Signaling in Cryptococcus neoformans
... a paracrine signaling role, activating morphological changes in mating partner cells that promote cell fusion and conjugation, similar to the role of pheromones in ...an autocrine signaling role, ...
12
Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche
... Interleukin-6 (IL-6) is one of the most important factors for MM cell growth and survival in vivo [4, 5]. There are two different sources of IL-6 in MM that promote tumor development and maintenance in vivo: ...
17
Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells
... by paracrine SDF-1α/CXCR4 signaling-induced activation of the intracellular FAK-AKT and ERK1/2 signaling pathways and a subsequent IL-6 autocrine loop in ...
13
Endothelin 1 is an autocrine/paracrine growth factor for human cancer cell lines
... These results demonstrate that ET-1 is synthesized by and released from human epithelial carcinoma cell lines, and that exogenous and endogenous ET-1 stimulates proliferation of the cell[r] ...
6
Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth
... expression vector synthesized and secreted high levels of ANP. These cells also showed significantly lower rates of DNA synthesis under basal and fibroblast growth factor (FGF)- stimulated conditions. Addition of ...
7
Natriuretic peptides inhibit angiotensin II induced proliferation of rat cardiac fibroblasts by blocking endothelin 1 gene expression
... autocrine/paracrine growth factor for cardiac fibroblasts, and to examine its interaction with cardiac natriuretic hormones. Expression of preproET-1 (ppET-1) mRNA by cultured cardiac fibroblasts from ...
8
The Transient Pore Formed by Homologous Terminal Complement Complexes Functions as a Bidirectional Route for the Transport of Autocrine and Paracrine Signals across Human Cell Membranes
... HUVEC exposed to the terminal complement components released bFGF but not LDH, a marker of cell lysis. Ghosts impacted by homologous MAC released bFGF, IL-1, and IFN,[r] ...
11
Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee
... with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, ...
7
Betaine supplement enhances skeletal muscle differentiation in murine myoblasts via IGF 1 signaling activation
... Several authors suggested that IGF-1 pathway operates in an autocrine/paracrine mode acting as an intrinsic mediator of skeletal muscle repair and adaptation, increasing the proliferatio[r] ...
12
Glutamate involvement in calcium–dependent migration of astrocytoma cells
... We demonstrate that the human astrocytoma cell line U87MG is able to release glutamate in the extracellular space which in turn, activates glutamate receptors in an autocrine/ paracrine [r] ...
10
Fractalkine is expressed in the human ovary and increases progesterone biosynthesis in human luteinised granulosa cells
... In our study, progesterone secretion was stimulated dose dependently by hCG in cultured luteinised granu- losa cells. Previous studies have shown that IL-1B, pro- lactin and pituitary adenylate cyclase-activating ...
8
Endocannabinoid signalling in the blood of patients with schizophrenia
... orders, since these compounds: (i) due to their lipophilicity act as autocrine/paracrine mediators, and no blood EC carrier protein has been identified to date; and (ii) are also produced by blood cells. ...
9
Evidence for direct local effect of angiotensin in vascular hypertrophy In vivo gene transfer of angiotensin converting enzyme
... In this study, we used in vivo gene transfer to increase local expression of vascular angiotensin converting enzyme and provided proof that increased autocrine/paracrine angiotensin can [r] ...
8