Autoimmune Diabetes
Dendritic cells in autoimmune diabetes
... In order to determine the role of dendritic cell subsets in the transfer of autoimmune diabetes, irradiated recipient mice expressing model autoantigen in the islet can be reconstituted [r] ...
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SUMO defective c Maf preferentially transactivates Il21 to exacerbate autoimmune diabetes
... Furthermore, SUMO-defective c-Maf selectively inhibited recruitment of Daxx/HDAC2 to the Il21 promoter and enhanced histone acetylation mediated by CREB-binding protein (CBP) and p300. Using pharmacological interference ...
16
Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes
... 2 diabetes; while in the Botnia study [6] after 13 years of diabetes 56% of LADA patients had ischemic heart disease and 5% had had cerebrovas- cular ...2 diabetes [8], and none have assessed that ...
9
Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes
... from diabetes, insulitis was occasionally observed and diabetes developed in a ...that diabetes preven- tion depends on the engraftment of multipotent Table ...
8
Reversal of established autoimmune diabetes by restoration of endogenous β cell function
... In NOD (nonobese diabetic) mice, a model of autoimmune diabetes, various immunomodulatory interventions prevent progression to diabetes. However, after hyperglycemia is established, such inter- ...
11
The Predictive Value of Biopsy of the Pancreas and Its Therapeutic Impact in Autoimmune Diabetes
... clinical diabetes, non-destructive insulitis phase which is haracterized by leukocyte extravasation from the peri-islet blood vessels and destructive insulitis phase, characterized by leucocyte penetration of the ...
8
Combined treatment with sitagliptin and vitamin D in a patient with latent autoimmune diabetes in adults
... Latent autoimmune diabetes in adults (LADA) is a relatively new type of diabetes with a clinical phenotype of type 2 diabetes (T2D) and an immunological milieu characterized by high titers of ...
5
Prevention of murine autoimmune diabetes by CCL22 mediated Treg recruitment to the pancreatic islets
... 1 diabetes is characterized by destruction of insulin-producing β cells in the pancreatic islets by effector T ...from autoimmune diabetes in NOD ...attenuates autoimmune destruction of β ...
6
CCR4 bearing T cells participate in autoimmune diabetes
... of autoimmune diabetes, implying that spleen and panLN’s are the sites for in vivo expansion and maintenance of the diabetogenic T cell ...no diabetes occurs, indi- cating the uncoupling of insulitis ...
13
A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes
... of autoimmune diabetes, in which the NP from LCMV is expressed transgenically as a self antigen in pancreatic β cells as well as the thymus, coupled with LCMV infection leads to LCMV-specific ...
10
Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide
... 1 diabetes and autoimmune diabetes–prone NOD ...spontaneous diabetes in treated ...inhibited diabetes development after a single intranasal ...
8
Characteristics and Prevalence of Latent Autoimmune Diabetes in Adults (LADA) in Torbat-e Heydarieh, Iran
... of diabetes in human societies during the past ...countries. Diabetes is an important public health problem and the number of the cases along with the prevalence of diabetes has been steadily ...
9
Original Article Potentials of long non-coding RNAs to differentiate latent autoimmune diabetes in adults from type 2 diabetes
... Abstract: Latent autoimmune diabetes in adults (LADA), which characteristically overlaps with type 2 diabetes (T2D), is often misdiagnosed. In this study, we aim to access potentials of lncRNAs to ...
8
Cytotoxic T lymphocyte antigen 4 +49A/G polymorphisms in Sudanese adults with type 1 diabetes and latent autoimmune diabetes
... Objectives: This study was conducted to assess the association of T-lymphocyte-associated protein 4 (CTLA-4 + 49A/G) variant with Latent autoimmune diabetes in adults (LADA) in Eastern Sudan. The study ...
5
Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes
... 1 diabetes (T1D) loci in latent autoimmune diabetes in adulthood (LADA) subjects positive for both glutamic acid decarboxylase autoantibodies and insulinoma-associated antigen-2 ...
10
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
... cell–dependent autoimmune response, we generated mice that lack cathepsin L (Cat L) on the autoimmune diabetes-prone NOD inbred ...I diabetes in the NOD ...
11
Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes
... from autoimmune diabetes, we generated transgenic NOD mice to enable temporal and cell-specific mouse PI expression in the antigen-presenting cells ...
12
B cell depletion: a novel therapy for autoimmune diabetes?
... Autoimmune diabetes is believed to be mediated primarily by T cells. How- ever, B cells have been implicated in the pathogenesis of the disease in NOD mice. Although preclinical studies have been limited by ...
5
Proinsulin: a unique autoantigen triggering autoimmune diabetes
... broken autoimmune disease can develop, during which autoreactive lymphocytes are directed to a variety of autoantigenic ...genic autoimmune response to proinsulin subsequently spreads to other antigens (see ...
5
Genetic Insights Into Latent Autoimmune Diabetes In Adults
... ‘Latent autoimmune diabetes in adults’ (LADA) is a controversial subtype of diabetes characterized by initial insulin independency and the presence of diabetes associated ...2 diabetes ...
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