autoimmune disorders
Autoimmune Disorders – Immunopathogenesis and Potential Therapies
... structure. Autoimmune diseases progresses from the stage of activation to chronic lesion via a rise in the number of neo-antigens targeted by lymphocytes and ...autoimmune disorders. This paper ...
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Emerging patterns of genetic overlap across autoimmune disorders
... of autoimmune disorders has been long recognized and supports a role for shared genetic ...certain autoimmune diseases among the relatives of individuals who have RA, MS, SLE, T1D and other diseases ...
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Natural killer cells in human autoimmune disorders
... By virtue of their ability to rapidly kill abnormal cells and produce cytokines and chemokines, NK cells infl uence and shape adaptive immune responses and are positioned to play a role in regulating autoimmune ...
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Shared Autoimmunity: A Case Series of 56 Patients with Immune Thrombocytopenia (ITP) Associated with Other Autoimmune Disorders
... more autoimmune disorders in the same individual has been attributed to “shared autoimmunity” caused by the interaction between genetic and environmental ...other autoimmune disorders. A total ...
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The emerging role of epigenetics in human autoimmune disorders
... several autoimmune disorders with the aim to provide new therapeutic ideas in this area of interest ...underlie autoimmune diseases from genotyping data ...such autoimmune dis- ...
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Review of 113 cases of autoimmune disorders in pregnancy
... of autoimmune disorder, maternal age, parity, status of disease at conception, treatment taken during pregnancy, maternal complications like pregnancy induced hypertension, gestational diabetes mellitus, ...
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Mechanisms of preventative and therapeutic role of probiotics in different allergic and autoimmune disorders
... allergic disorders stemmed from the fact that they have been shown to improve intestinal permeability and reduce inflammatory ...as autoimmune disorders [10, ...
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The role of epigenetic mechanisms and processes in autoimmune disorders
... are observations of elevated levels of CD154 in a multitude of autoimmune disorders, including SLE, autoimmune thyroid disease, T1D, inflammatory bowel disease, psoriasis, MS, and RA. Although the ...
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Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response
... Abstract: The thiopurine S-methyltransferase (TPMT) gene encodes for the TPMT enzyme that plays a crucial role in the metabolism of thiopurine drugs. Genetic polymorphisms in this gene can affect the activity of the TPMT ...
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Environmental influences on multiple sclerosis and other autoimmune disorders
... WHAT THIS STUDY ADDS In Australia there is a reciprocal pattern of month of birth and risk of multiple sclerosis, with a higher risk for those born in November-December compared with May[r] ...
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Pharmacotherapy of Autoimmune Disorders
... Significant safety concerns exist for tofacitinib. The rate of serious infections, opportunistic infection, and death from serious infection was higher in the tofacitinib groups than adalimumab or placebo, even after ...
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Cannabidiol Limits T Cell-Mediated Chronic Autoimmune Myocarditis: Implications to Autoimmune Disorders and Organ Transplantation
... Myocarditis is a major cause of dilated cardiomyopathy and subsequent chronic heart failure leading to arrhythmias, sudden cardiac death and cardiac trans- plantation (3). Among several factors, autoimmunity plays an ...
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Utilization of leukapheresis and CD4 positive selection in Treg isolation and the ex-vivo expansion for a clinical application in transplantation and autoimmune disorders
... T regulatory cells (Tregs) have ability to regulate immune reaction and maintain self-tolerance attenuating autoimmunity, allergy, pathogen-induced immunopathology and over-exuberant immune responses [1–4]. Due to their ...
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Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
... Introduction: Genome wide association studies, replicated by numerous well powered validation studies, have revealed a large number of loci likely to play a role in susceptibility to many multifactorial diseases. It is ...
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The role of adalimumab in rheumatic and autoimmune disorders: comparison with other biologic agents
... Systemic rheumatic diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), and juvenile inflammatory arthritis have partially overlapping clinical manifestations of ...
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Clinical presentation of autoimmune disorders in pregnancy
... At admission, oral ulcers were present, rash was present over the malar area and abdominal examination showed 28 weeks gestation suggestive of IUGR. Whole blood count improved to 10,600 but platelet count dropped to ...
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Involvement of miR-126 in autoimmune disorders
... an autoimmune disease that cause non-septic proliferative synovitis and may com- promise the integrity of bone and cartilage tissues, thus causing articular dysfunction ...various autoimmune diseases [17– ...
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Utility of Placental Umbilical Cord Blood in Autoimmune and Degenerative Disorders
... malignancies, autoimmune disorders, anaemia, geriatric disorders and leprosy have been reported in few studies, and did not reveal any adverse event due to UCB transfusion ...
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Autoimmune haematological disorders in two Italian children with Kabuki Syndrome
... susceptibility to infections and autoimmune disorders as idiopathic thrombocytopenic purpura (ITP), haemolytic anemia, thyroiditis and vitiligo [5,6]. The prevalence of major findings is summarised in the ...
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Atypical phenotypic aspects of autoimmune thyroid disorders in young patients with Turner syndrome
... Whatever the mechanism of the enhanced susceptibil- ity of TS girls to AITDs, it may be argued, however, that these patients are, per se, more exposed to this risk, irre- spective of familial predisposition, or ...
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