autophagic cell death
Autophagic cell death participates in POMC induced melanoma suppression
... promoting cell death during POMC-mediated melanoma suppression via α -MSH/HIF-1 α /BNIP3/BNIP3L signaling ...and autophagic cell death through a hypoxia- inducible factor-1 ...
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Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia
... leukemia cell lines, lapatinib induced apoptosis in HL-60, NB4, and Jurkat cells, but induced nonapoptotic cell death in U937, K562, and MEG-01 ...caused autophagic cell death as ...
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Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma
... Autophagic cell death was demonstrated by images of punctuated LC3 patterns, a higher percent of acridine orange positive cells, as well as a partial rescue of cell death by autophagy ...
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Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells
... autophagy, autophagic cell death, vacuolization, colon cancer, zanthoxylum fruit Received: February 09, 2016 Accepted: September 02, 2016 Published: September 10, 2016 ABSTRACT Zanthoxylum fruit, ...
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Oncogenic Ras Induced Expression of Noxa and Beclin 1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
... Ras-initiated cell death, we used a tetracycline-inducible H-Ras V12 human ovarian surface epithe- lial (HOSE) cell line, previously characterized by Hancock and colleagues (Nicke et ...induced ...
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Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia
... significant autophagic cell death, and resulted in enhanced cell killing in a variety of leukemic cell lines and primary leukemic ...SG511-BECN-induced autophagic cell ...
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Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma
... leukemia/lymphoma cell lines, as well as in primary tumor cells and a murine xenograft ...tumor cell growth and triggered the autophagic cell death, with a significant inhibition of ...
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UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells
... ROS-dependent cell death, as indicated by the apoptosis decrease in the presence of the autophagy inhib- itors chloroquine (CQ) or 3-methyladenine (3-MA), or the radical scavenger ...the autophagic ...
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Tetrandrine, an activator of autophagy, induces autophagic cell death via PKC-α inhibition and mTOR-dependent mechanisms.
... enhance cell death in apoptosis-resistant cancer ...these cell lines compared to the WT cells, suggesting that tetrandrine might induce cell death in the absence of ...
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Aurora kinase A suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells
... alternative death mechanisms for the effective management of tumor ...of autophagic cell death showed potential clinical benefits for cancer ...induced autophagic cell ...
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CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K Akt mtor pathway inhibition
... gosomes and autolysosomes, and autophagic flux activation. By contrast, CXCR4 overexpression blocked autophagy, as shown by reduced expression of beclin 1 and LC3B‑II, a lower number of autophagosomes and ...
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Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells
... tumor cell lines, with some of the antitumor effects being achieved at physiologically relevant concentrations, and without affecting normal cells, including human bronchial epithelial (NHBE) cells [3, ...
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<p>Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway</p>
... and autophagic cell death are the two com- mon mechanisms by which chemotherapeutic drugs induce ...by cell shrinkage, cell membrane blebbing, nuclear and DNA fragmentation, chromatin ...
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Original Article Propofol prevents against oxygen glucose deprivation and reperfusion-induced autophagic cell death in H9c2 cells by increasing miR-30
... Benqing Wang 1 , Jinde Liu 2 , Shiqiang Shan 1 1 Cangzhou Central Hospital, Xinhua West Road 16, Cangzhou 061001, Hebei, China; 2 Huabei Petroleum General Hospital, Huizhan Rode, Renqiu, Hebei, China Received May 17, ...
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Suppression of PC-1/PrLZ sensitizes prostate cancer cells to ionizing radiation by attenuating DNA damage repair and inducing autophagic cell death
... reduced cell repair of DNA double-strand breaks (DSBs) and attenuated activation of the G2 ...of autophagic cell death but not apoptosis and senescence after ...
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A novel DNA damage response mediated by DNA mismatch repair in Caenorhabditis elegans: induction of programmed autophagic cell death in non-dividing cells
... We obtained the interesting findings that the sensitivity of mlh-1(ok1917) cells differed among pachytene stage meiotic cells, dSCs, and ndSCs (Figures 1-3). In addition, MMR induced autophagic cell ...
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Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal
... undergo autophagic cell death (ACD) following insulin withdrawal without apoptotic signs despite their normal apoptotic ...impaired autophagic flux, consistent with its known role in ...
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Autophagic cell death: A new frontier in cancer research
... and cell differentiation; 2) in the degrada- tion of intracellular proteins; 3) in the production of amino acids when there is a decrease of nutrients; 4) in the mechanism of exchange of citomembrane and organ- ...
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Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth
... to autophagic- and caspase-mediated cell death in a p53-independent ...enhances autophagic flux by clearance of p62 in chemoresistant ovarain cancer (OvCa) cell lines to a greater ...
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