Autophagic degradation
Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
... the degradation of NEMO/IKKγ by autophagy 35 ...for degradation in a lysosome by interacting with Atg8a via its LIR ...for autophagic degradation by ubiquitina- tion; host type 2, in which ...
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Sensing and signaling for peroxisome autophagic degradation (pexophagy) in yeasts
... yeast cells, similarly to cells of other eukaryotic organisms, possess intracellular organelles, including that of peroxisomes also known as microbodies . Enzymes of oxidative metabolism, mainly hydrogen peroxide ...
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XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells
... the degradation of Sox2 and found that degradation of Sox2 can be reversed by autophagy inhibitors bafilomycinA1 and chloroquine (CQ), but not proteasome inhibitor MG132 ...
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CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L
... On the basis of findings above, we hypothesized that CSN6 and several essential proteins involved in the regulation of autophagy (mTOR, LC3, p62 and CTSL) might have interactive or regulatory relation- ships. ...
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Huhs1015 reduces pkm2 protein due to autophagic degradation in gastric cancer cells
... to autophagic degradation: In the Western blot analysis, HUHS1015 (100 μM) decreased PKM2 protein in a treatment time (10-60 min)- dependent manner in MKN28 cells (Figure ...to autophagic ...
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The HDAC6/APOBEC3G complex regulates HIV 1 infectiveness by inducing Vif autophagic degradation
... In fact, we observed a clear-cut correlation between the HDAC6 ability to degrade HIV-1 Vif and the restoration of A3G level in cells producing virions and HIV-1 infec- tiveness, regardless viral tropism. Indeed, HIV-1 ...
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Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6
... inhibits autophagic protein degradation, these results suggested that HCV depleted TRAF6 via ...The degradation of TRAF6 was apparently mediated by the p62 sequestosome protein, which is a factor ...
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PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma
... Previous evidences demonstrated that PHF8 contributes to DNA damage protection, anti-apoptosis, and activation of cell cycle and EMT [13–19]. Notably, great importance has been attached to the implication of PHF8 in ...
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Inhibition of ER /ERK/P62 cascades induces “autophagic switch” in the estrogen receptor-positive breast cancer cells exposed to gemcitabine
... promote autophagic degradation ...inhibit autophagic degradation did not render P62 increase when compared to MCF-7 cells with si-ERα alone after gemcitabine treatment (Figure ...of ...
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Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation
... regulating autophagic degradation [41, ...consequent autophagic degrad- ation in OSCC cells treated with bortezomib alone or in combination with IR ...
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Pkm2 is a target of huhs1015 for inducing colonic cancer cell death
... PC-3 human prostate cancer cells; and ACHN, RCC4 and 786-O human renal cancer cells though diverse signal transduction pathways (Kanno et al., 2013; Nishizaki 2014). For colonic cancer cells, HUHS1015 induces necrosis by ...
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Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease
... the degradation of α-syn, converging evidence from genetic, pathological and experimental studies has provided indications that the ALP is compromised in PD ...of autophagic degradation activity ...
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Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy
... We asked if KP46-induced early mitochondrial functional/morphological damage and the up-regulation of LC3-II commit impaired mitochondria to removal by autophagy. We quantified the mitochondrial content of HCT116 cells ...
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Huhs1015 downregulates pkm2 through an ampk/p38mapk pathway in mkn45 cells
... to autophagic degradation (unpublished ...promotes autophagic degradation through specific phosphorylation of autophagy-relevant proteins or by indirectly impacting in the activity of ...
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Regulation of Apolipoprotein E Trafficking by Hepatitis C Virus-Induced Autophagy
... the degradation of ApoE in HCV-infected cells, we also performed a small interfering RNA (siRNA) knockdown experiment to suppress the expression of ATG7, a protein factor important for ...3 Autophagic ...
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Viral strategies of manipulating autophagy to benefit infection
... limits autophagic degradation is currently ...autolysosomal degradation has not been elucidated, emphasising the importance of identifying the specific virus or host components that prevent ...
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Structural, Biochemical, and Cell Biological Characterization of Rab7 Mutants That Cause Peripheral Neuropathy
... for autophagic degradation, or whether undigested autophagy substrates are futilely ubiquitinated after ...protein degradation with resultant accumulation of ubiquitinated protein ...
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A Small Viral PPxY Peptide Motif To Control Antiviral Autophagy
... from autophagic degradation, we also showed that AdVs are able to limit autophagy by preventing efficient autopha- gosome maturation even after they have escaped ...
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The different roles of selective autophagic protein degradation in mammalian cells
... triggered autophagic cell death by K-Ras autophagic degradation and disrupting the interaction between Bcl-XL and Beclin1, therefore playing a significant role in killing tumor cells [137, ...
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The Role of NCOA4-Mediated Ferritinophagy in Iron Homeostasis
... Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin (“ferritinophagy”), the cytosolic iron storage complex. NCOA4-mediated ...
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