Autophagy flux
Human prion protein-induced autophagy flux governs neuron cell damage in primary neuron cells
... inhibited autophagy flux in Zpl 3-4 cells (Figure 6E, 6F), and that PrPc expression was displayed in ZW 13-2 cells (Figure ...of autophagy flux in Zpl 3-4 cells (Figure ...whether ...
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NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer
... as autophagy, a conserved eukaryotic catabolic reaction for removal and recycling, thereby it has been proposed as a mechanism of chemoresistance to alkylating drugs ...context, autophagy may lead to tumor ...
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Neuroinflammation contributes to autophagy flux blockage in the neurons of rostral ventrolateral medulla in stress-induced hypertension rats
... immunostaining. Autophagy and autophagic vacuoles (AVs) were examined by autophagic marker (LC3 and p62) expression and transmission electron microscopy (TEM) image, ...respectively. Autophagy flux ...
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Autophagy flux induced by ginsenoside-Rg3 attenuates human prion protein-mediated neurotoxicity and mitochondrial dysfunction
... by autophagy flux should be able to preserve cellular ...that autophagy flux could undermine prion protein-induced mitochondria injury, suggesting that autophagy is closely associated ...
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Iron oxide nanoparticles and induced autophagy in human monocytes
... on autophagy induced by Dex-SPIONs in human primary ...of autophagy or blockade of autophagy ...induced autophagy but did not block autophagy ...
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Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway
... hibits autophagy by activating mTOR but also sup- presses lysosomal ...upregulating autophagy in- duction and downregulating autophagosome ...inhibited autophagy flux, which concurred with the ...
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MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma
... of autophagy including BECN1, SQSTM1 and the conversion of LC3I (cytosolic form) to LC3II (lipidated, autophagosome membrane- bound form) by western blotting ...induces autophagy flux or blocks ...
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Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE mice
... altering autophagy [19]. To determine the potential involvement of autophagy and autophagic flux in the effects of TET2 on ox-LDL-treated endothelial cells, we pretreated HUVECs with either TET2 ...
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Deep morphological analysis of muscle biopsies from type III glycogenesis (GSDIII), debranching enzyme deficiency, revealed stereotyped vacuolar myopathy and autophagy impairment
... In order to characterize GSDIII muscle morphological spectrum and identify novel disease markers and pathways, we performed a large international multicentric morphological study on 30 muscle biopsies from GSDIII ...
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Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition
... and autophagy-lysosomal function resulting in protein aggregation, mitochondrial impairment, oxidative stress and exosome release – all of which are the topics of interest in the present ...and autophagy ...
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A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila
... to autophagy induction or of autophagosomal degrad- ation defects inducing a blockade of the autophagy ...which autophagy was acti- vated by starving the larvae for 4 h in a solution of 20% sucrose, ...
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Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal
... of autophagy flux at basal ...high autophagy level following in- sulin withdrawal, depletion of VCP activity affects the early stage of autophagy flux and diminishes the autoph- agy ...
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PGC-1α modulates denervation-induced mitophagy in skeletal muscle
... LC3B-II flux were lower in KO animals, as evidenced by a smaller accumulation of LC3BII and p62 in KO animals treated with colchicine (Figure ...and autophagy flux in KO and WT animals using confocal ...
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Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease
... phages). Autophagy flux, mitochondrial dysfunction, inflammasome activation and efferocitosis capacity were examined in chemically-induced Gaucher THP-1 macro- ...
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The beneficial role of proteolysis in skeletal muscle growth and stress adaptation
... and autophagy- related signaling during muscle ...promote autophagy flux by cleaving and inhibiting the key autophagy suppressing protein SesB ...Whereas autophagy has been generally ...
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Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1
... program. Autophagy serves as a dynamic recycling mechanism and provides energy or metabolic ...whether autophagy is a protective or detrimental ...impaired autophagy compared to wild-type ...improve ...
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The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer
... increased autophagy, glycolysis and senescence ...an autophagy-induced protumori- genic effect in the CAFs or antineoplastic effects in epithe- lial cancer cells, suggests that the activation of an ...
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Autophagy decreases alveolar macrophage apoptosis by attenuating endoplasmic reticulum stress and oxidative stress
... of autophagy on alveolar macrophage apoptosis and its mechanism in the early stages of hypoxia, we established a cell hypoxia-reoxygenation model and orthotopic left lung ischemia-reperfusion ...with ...
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Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62
... autophagic flux, we evaluated whether a block of autophagosomal degradation after 6 h BafA1 treatment would interfere with viral ...which autophagy was activated by either Torin1 treatment or nutrient ...
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Enterovirus 71-induced autophagy increases viral replication and pathogenesis in a suckling mouse model
... Virus-mediated autophagy may en- hance viral replication or evade immune surveillance ...induce autophagy in the brain tissues of the infected mice ...induces autophagy, which plays a promoting role ...
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