Autophagy inhibition
Basal autophagy is pivotal for Hodgkin and Reed-Sternberg cells’ survival and growth revealing a new strategy for Hodgkin lymphoma treatment
... basal autophagy in primary tissue and cell lines suggests that this process may be essential for growth and survival of cHL ...both autophagy inhibitors induced apoptosis in L428 and KMH2 cells after 36 hrs ...
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ATG7 regulates energy metabolism, differentiation and survival of Philadelphia chromosome-positive cells
... born autophagy- de fi cient) or techniques used (complete knockout ...specific autophagy inhibition and TKI treatment might lead to deeper response rates in CML patients with increased chance of ...
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JLawton Final Honors Thesis 2018.pdf
... approaches. Autophagy, a self-degradative pathway that provides metabolic substrates and recycles damaged proteins and organelles, has been implicated in supporting cancer survival, progression towards metastasis, ...
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miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway
... to autophagy inhibition [33, 40, ...basal autophagy and TMZ-induced autophagy, suggesting that STAT3 was involved in the induction of autophagy in ...modulate autophagy through a ...
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Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model
... moderate autophagy has a protective effect against apoptosis in NP ...induce autophagy in various tissues as ...activated autophagy in NP cells. However, autophagy inhibition markedly ...
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Dihydromyricetin promotes autophagy and apoptosis through ROS-STAT3 signaling in head and neck squamous cell carcinoma
... 14]. Autophagy can either suppress or promote tumor cell growth in different cellular contexts [15- ...which autophagy functions as a primary mechanism of cell death or survival remain to be defined, a ...
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Targeting autophagy in cancer management – strategies and developments
... Abstract: Autophagy is a highly regulated catabolic process involving lysosomal degradation of intracellular components, damaged organelles, misfolded proteins, and toxic aggregates, reducing oxidative stress and ...
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Genetic inhibition of autophagy promotes p53 loss-of- heterozygosity and tumorigenesis
... that autophagy inhibition acts directly on a neural precursor cell and mediates or facilitates ...the autophagy pathway [62, 63], has very recently been shown to contribute to the pathogenesis of ...
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TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis
... regulate autophagy. As mentioned in the introduction, autophagy displays a dy- namic and complicated function in cancer [21, 29, 35, 36] and can suppress tumorigenesis and metastasis in re- sponse to some ...
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Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas
... [4]. Autophagy also has diverging roles with respect to tumor immune surveillance given its effect on the tumor microenvironment and function in antigen presentation [5, ...basal autophagy in EAC cell ...
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Salt Tectonism In The Carolina Trough
... However, autophagy blockage at later stage by Bafilomycin A1 did not rescue cells from miR-489 induced ...of autophagy attenuated effect of autophagy inhibitors that block later stages (Geng, Kohli, ...
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Inhibition of Cellular Autophagy Deranges Dengue Virion Maturation
... these pathogens has been hampered by the lack of selective small- molecule inhibitors of the pathway. Until recently, the only avail- able small-molecule inhibitor of the pathway was 3-methyl- adenine (3-MA), which has a ...
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Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells
... growth inhibition and apoptosis in K562 and KU812 ...(LC3)-positive autophagy- like vacuoles, and the upregulation of ...asparaginase-induced autophagy in K562 cells. Moreover, blocking ...
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Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy
... Although autophagy is known to act as a critical host defense mechanism against viral infection in cells (24, 25), influenza A virus is known to subvert autophagy for ...reduce autophagy and maintain ...
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Effect of γ34.5 Deletions on Oncolytic Herpes Simplex Virus Activity in Brain Tumors
... in autophagy-deficient MEFs (Atg5 ), whereas BBD deletion mutants replicated similarly to their wild- type revertants (1, ...that autophagy and its inhibition are not critical to HSV replication in ...
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Determining the Role of Autophagy in HER2/neu-Induced Mammary Tumor Dormancy and Recurrence
... affected autophagy-independent functions of Beclin 1. These autophagy-independent functions of Beclin 1 were first suggested to exist when it was observed that Beclin 1 -/- mice had a much more severe ...
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miR-340 suppresses glioblastoma multiforme
... While it has been reported previously that miR-340 inhibits osteosarcoma cell proliferation and metastasis by directly targeting ROCK1 [20], their interaction and functional relevance have not yet been elucidated in ...
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Glycolysis inhibition via mTOR suppression is a key step in cardamonin induced autophagy in SKOV3 cells
... Autophagy is an evolutionarily conserved mechanism of adaptation to microenvironmental conditions, such as me- tabolism inhibition. It ensures the survival and prolifera- tion of cancer cells under hypoxia ...
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Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS
... the inhibition effect of 3-MA on berberine- mediated decrease of TDP-43 ...that inhibition of autophagy by 3-MA reverses the effect of berberine on TDP-43 pathogenesis, and activation of ...
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Regulation of adipocyte autophagy — The potential anti-obesity mechanism of high density lipoprotein and ApolipoproteinA-I
... induce autophagy in mammalian cells ...upregulated autophagy and impaired mitochondria in human adipo- cyte from obese patient with Type 2 Diabetes ...
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