Autophagy-mediated cell death
PM2.5 induces autophagy-mediated cell death via NOS2 signaling in human bronchial epithelium cells
... elevated autophagy level was related to ...programmed cell death phenotype was simultaneously appeared in the cellular content, like blebbing, cell shrinkage, karyopyknosis, mito- chondrial ...
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Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway
... ing autophagy [23], was also assessed in SKOV3 ...of autophagy by ...induced autophagy in SKOV3 ...the autophagy induced by APG-1387 treatment ...of autophagy triggered by APG-1387 in ...
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Cannabinoid action induces autophagy mediated cell death through stimulation of ER stress in human glioma cells
... of autophagy prevents THC-induced cancer cell ...total cell number is shown in the corner of each panel (mean ± ...on cell viability (F; mean ± SD; n = 3), LC3 immunostaining (G, left panels; ...
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Ecdysone mediated programmed cell death in Drosophila
... med24 as they require the function of all three primary response genes for their expression during larval salivary gland PCD and are needed for the downstream expression of rpr and hid (Ihry and Bashirullah, 2014). The ...
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Original Article Overexpression of PTEN enhanced gemcitabine-induced apoptosis by promoting autophagy in osteosarcoma cell line MG-63
... derived cell lines MG-63 could sensitize cell for gemcitabine-induced ...induce autophagy in MG-63 cell and PTEN-mediated autophagy was required for enhancing apoptosis induced ...
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Differential Induction of Er Stress, Autophagy and Cell Death in Trichomonas Vaginalis -Infected Siha Cells
... be mediated by UPR. The UPR is mediated by three ER-resident transmembrane proteins that can act as ER stress sensors, IRE1, PERK and ATF6, which are in turn regulated by BiP (also known as glucose ...
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<p>Targeting off-target effects: endoplasmic reticulum stress and autophagy as effective strategies to enhance temozolomide treatment</p>
... of autophagy in the treatment of GBM with TMZ remains controversial, and the mechanism by which autophagy switches between a pro-survival and a pro-death role remains ...and autophagy, it is ...
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Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells
... In the present study, we aimed to investigate the ef- fects of the combination of chemotherapy with CQ on two kinds of gallbladder-carcinoma-derived cells, namely SGC-996 and GBC-SD. 5-FU is one of the major antitu- mor ...
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Sorafenib-induced defective autophagy promotes cell death by necroptosis
... perform autophagy-mediated protein degradation when subjected to stressors such as etoposide ...Atg5/Atg7-independent autophagy is not regulated by Ulk1 and Beclin1 but by Rab9, the GTPase that ...
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Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death
... Our earlier studies show that cells respond to Salinomycin treatment with autophagy, as a cell survival mechanism. However to our surprise, under glucose starvation conditions, Salinomycin treatment did not ...
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Suppression of mTOR pathway and induction of autophagy- dependent cell death by cabergoline
... CAB-mediated cell death of MMQ cells (p < 0.05). CAB-induced autophagy and blockade of autophagy flux participated in antitumoral action in ...induces autophagy and inhibits ...
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Overexpression of selenoprotein H prevents mitochondrial dynamic imbalance induced by glutamate exposure
... glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic ...initiated cell death ...induced cell death is mediated through mitochondrial ...
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Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment
... apoptotic cell death: extrinsic apoptosis pathways and intrinsic apoptosis ...of death ligands and death receptors. Death receptors belong to the tumor necrosis factor receptor ...
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<p>The molecular mechanisms underlying BCR/ABL degradation in chronic myeloid leukemia cells promoted by Beclin1-mediated autophagy</p>
... autophagic death in tumor cells repre- sents a new route for leukemia ...the autophagy gene Beclin1 downregulated BCR/ABL protein expression and signi fi cantly increased the killing effect of the oncolytic ...
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The selectivity and specificity of autophagy in drosophila
... cells death in late Drosophila oogenesis and that there was a significant decrease in TUNEL positive staining in dICAD ...of autophagy genes for cell death ...sister cell, the oocyte, ...
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Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death
... regulate cell growth, differentiation, motility and ...regulate autophagy by affecting several signaling pathways including the mTOR ...pathway. Autophagy is a process that regulates the balance ...
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Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway
... that autophagy also has a role in non-autophagic processes, especially in the secretory pathway ...the autophagy-based secretory pathway regulates the unconventional secretion of several cytosolic proteins ...
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Modulation of innate immunity by nucleotide binding : biochemical and functional characterization of a CATERPILLER_NLR protein, Monarch-1_NLRP12
... ASC deficient mice are protected from lethal dose of LPS (51). Interestingly, cryopyrin mice only show enhanced survival in a low lethal dose of LPS treatment (9.38mg/Kg), however, ASC deficient mice are resistant to ...
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K+ATP CHANNELS MODULATE HAEMODYNAMICS, BIOCHEMICAL AND HEMATOLOGICAL AFTER PRETREATMENT WITH THE K (ATP) OPENER PINACIDIL AND PHOSPHOLIPASE C INHIBITOR ON ETOMIDATE IN THE MICE
... induce cell death in different cell lines, being reported mainly apoptosis and necrosis as the principal pathways of cell death mediated by blockage of K + channels or the Na, ...
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Three Bufadienolides-Induced Human Lung Cancer CL1-5 Cell Death Mainly through Autophagy
... activated autophagy process to induce cell death in CL1-5 highly metastatic human lung cancer cells. Among these three compounds, kalantuboside B exhibited a better autophagy induction a[r] ...
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