Aβ, Amyloid β protein
Deciphering the genesis and fate of amyloid β protein yields novel therapies for Alzheimer disease
... of Aβ, in ...or β-secretase (in preclinical develop- ment), as well as active or passive “Aβ ...synthetic Aβ pep- tide was found to induce an antibody response that low- ered cerebral ...
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The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... the amyloid-β protein (Aβ) was isolated from brains with amyloid depositon and it was subsequently identified as the core protein of neuritic plaques ...[4,5]. Aβ is ...
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Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study
... of β-amyloid peptide (Aβ), a part of the β- amyloid precursor protein (βAPP), forms neurotoxic amyloid plaques in the septic brain [14, ...by β APP staining is now ...
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The potential role of amyloid β in the pathogenesis of age related macular degeneration
... Concentration of immunoreactive VEGF in culture supernatants of RPE cells. Human RPE cells were incubated with various concentrations of Aβ (1∼25 µM), and VEGF protein expression in the culture supernatants ...
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Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... precursor protein (APP) processing [13, 18]. A β levels are mainly determined by the kinetic of SorLA and APP interaction according to the mathematic model which supports the fact that APP sorting pathway ...
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The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets
... of Aβ in the arterioles and capillaries of CAA patients might activate the comple- ment ...[84]. Aβ binding to C1q can activate complement system by classical pathway or by alternative pathway without C1q ...
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Stem cells for the treatment of neurodegenerative diseases
... of amyloid-β peptide (Aβ) plaques and neurofi brilary tangles [21,27-29], results in the death of several types of neuronal lineage cells within multiple regions of the brain [29-31], specifi cally ...
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Insights into the roles of lncRNAs in skeletal and dental diseases
... splicing; Aβ 1-42: amyloid-β 1-42; BACE1: β-secretase-1; BMSC: bone marrow stem cell; BMP-2: bone morphogenetic protein 2; CDCP1: CUB-domain-containing protein 1; ceRNA: ...
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The autophagy related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
... a protein with a key role in autophagy, was decreased in affected brain regions of patients with Alzheimer disease (AD) early in the disease ...human amyloid precursor protein (APP), a model for AD, ...
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The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice
... intracellular Aβ-aggregates in neurons in the absence of Aβ-plaques, and develops CA1 neuron loss and motor deficits ...because Aβ is produced in- dependent from APP in these mice but we used the ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... the β-secretase and γ-secretase enzymes, releasing the Aβ peptides into the luminal/ extracellular ...total Aβ secre- tion in both Swedish APP transfected cells and skin fi broblasts from carriers of ...
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The role of cerebral amyloid β accumulation in common forms of Alzheimer disease
... cytoskeletal protein tau, and these diseases are therefore called tauopathies ...toxic Aβ oligo- mers that induce tangle formation but not plaques, but no prec- edent exists for such a ...
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Amyloid mis-metabolism in idiopathic normal pressure hydrocephalus
... γ-secretase [10, 12, 13, 32], and the results could indi- cate that the two substrates compete with each other at the active site of γ-secretase. If APP expression is reduced, as most data suggest it is in iNPH, there ...
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Review of Alzheimer’s Disease: Treatments and New Pharmacological Strategies
... of β-amyloid measured by Individual Photon Emission Computed Tomography (SPECT) were detected 15 years before the onset of clinical ...tau protein concentrations in the CSF and the increase in brain ...
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Modeling Alzheimer's disease with non-transgenic rat models
... the amyloid precursor protein (APP) and its central role in the familial form of ...tau protein that is not encountered in AD but pertains to the frontotemporal dementia with Parkinsonism linked to ...
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Decreasing the expression of PICALM reduces endocytosis and the activity of β secretase: Implications for Alzheimer's disease
... expression of isoform 1 was lower than isoform 2 in H4 cells, we investigated whether the isoforms had differ- ential effects on APP endocytosis and processing. We depleted isoform 1 and 2 individually using specific ...
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Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... A β : amyloid β peptide; AD: Alzheimer ’ s disease; APH-1: anterior pharynx- defective 1; APP: amyloid β precursor protein; BACE-1: β -site amyloid precursor ...
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The activity of amyloid beta binding alcohol dehydrogenase in Alzheimer's disease
... !Neuronal! death! and! mitochondrial! dysfunction! in! AD! originates! from! the! necrosis!and!apoptotic!pathways!leading!from!mitochondria.!In!AD,!the!presence! ...
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Decreased levels of soluble amyloid β protein precursor and β amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus
... Altogether, our results show that there is increased pro- duction of TGF-β and an ongoing destruction of brain parenchyma (manifested as increased tau levels) in the brains of SLE patients. We suggest that levels ...
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Advances in the pathogenesis of Alzheimer’s disease: a re evaluation of amyloid cascade hypothesis
... apolipo- protein E (ApoE) genotyping, hyperphosphorylation of cytoskeletal proteins, oxidative stress, abnormal cell cycle re-entry, inflammation and Aβ ...The amyloid metabolic cascade and the ...
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